| Identification |
|---|
| HMDB Protein ID
| CDBP01928 |
| Secondary Accession Numbers
| Not Available |
| Name
| Tumor necrosis factor ligand superfamily member 11 |
| Description
| Not Available |
| Synonyms
|
- CD254 antigen
- ODF
- OPGL
- Osteoclast differentiation factor
- Osteoprotegerin ligand
- RANKL
- Receptor activator of nuclear factor kappa-B ligand
- TNF-related activation-induced cytokine
- TRANCE
- Tumor necrosis factor ligand superfamily member 11, membrane form
- Tumor necrosis factor ligand superfamily member 11, soluble form
|
| Gene Name
| TNFSF11 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in tumor necrosis factor receptor binding |
| Specific Function
| Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy |
| GO Classification
|
| Component |
| cell part |
| membrane |
| Function |
| binding |
| cytokine receptor binding |
| tumor necrosis factor receptor superfamily binding |
| tumor necrosis factor receptor binding |
| protein binding |
| receptor binding |
| Process |
| immune system process |
| immune response |
|
| Cellular Location
|
- soluble form:Secreted
- Tumor necrosis factor ligand superfamily member 11
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 13q14 |
| SNPs
| TNFSF11 |
| Gene Sequence
|
>954 bp
ATGCGCCGCGCCAGCAGAGACTACACCAAGTACCTGCGTGGCTCGGAGGAGATGGGCGGC
GGCCCCGGAGCCCCGCACGAGGGCCCCCTGCACGCCCCGCCGCCGCCTGCGCCGCACCAG
CCCCCCGCCGCCTCCCGCTCCATGTTCGTGGCCCTCCTGGGGCTGGGGCTGGGCCAGGTT
GTCTGCAGCGTCGCCCTGTTCTTCTATTTCAGAGCGCAGATGGATCCTAATAGAATATCA
GAAGATGGCACTCACTGCATTTATAGAATTTTGAGACTCCATGAAAATGCAGATTTTCAA
GACACAACTCTGGAGAGTCAAGATACAAAATTAATACCTGATTCATGTAGGAGAATTAAA
CAGGCCTTTCAAGGAGCTGTGCAAAAGGAATTACAACATATCGTTGGATCACAGCACATC
AGAGCAGAGAAAGCGATGGTGGATGGCTCATGGTTAGATCTGGCCAAGAGGAGCAAGCTT
GAAGCTCAGCCTTTTGCTCATCTCACTATTAATGCCACCGACATCCCATCTGGTTCCCAT
AAAGTGAGTCTGTCCTCTTGGTACCATGATCGGGGTTGGGCCAAGATCTCCAACATGACT
TTTAGCAATGGAAAACTAATAGTTAATCAGGATGGCTTTTATTACCTGTATGCCAACATT
TGCTTTCGACATCATGAAACTTCAGGAGACCTAGCTACAGAGTATCTTCAACTAATGGTG
TACGTCACTAAAACCAGCATCAAAATCCCAAGTTCTCATACCCTGATGAAAGGAGGAAGC
ACCAAGTATTGGTCAGGGAATTCTGAATTCCATTTTTATTCCATAAACGTTGGTGGATTT
TTTAAGTTACGGTCTGGAGAGGAAATCAGCATCGAGGTCTCCAACCCCTCCTTACTGGAT
CCGGATCAGGATGCAACATACTTTGGGGCTTTTAAAGTTCGAGATATAGATTGA
|
| Protein Properties |
|---|
| Number of Residues
| 317 |
| Molecular Weight
| 35477.8 |
| Theoretical pI
| 7.74 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Tumor necrosis factor ligand superfamily member 11
MRRASRDYTKYLRGSEEMGGGPGAPHEGPLHAPPPPAPHQPPAASRSMFVALLGLGLGQV
VCSVALFFYFRAQMDPNRISEDGTHCIYRILRLHENADFQDTTLESQDTKLIPDSCRRIK
QAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQPFAHLTINATDIPSGSH
KVSLSSWYHDRGWAKISNMTFSNGKLIVNQDGFYYLYANICFRHHETSGDLATEYLQLMV
YVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKLRSGEEISIEVSNPSLLD
PDQDATYFGAFKVRDID
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| O14788 |
| UniProtKB/Swiss-Prot Entry Name
| TNF11_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF019047 |
| GeneCard ID
| TNFSF11 |
| GenAtlas ID
| TNFSF11 |
| HGNC ID
| HGNC:11926 |
| References |
|---|
| General References
| Not Available |