| Identification |
|---|
| HMDB Protein ID
| CDBP01911 |
| Secondary Accession Numbers
| Not Available |
| Name
| Haptoglobin |
| Description
| Not Available |
| Synonyms
|
- Haptoglobin alpha chain
- Haptoglobin beta chain
|
| Gene Name
| HP |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hemoglobin binding |
| Specific Function
| Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes |
| GO Classification
|
| Component |
| extracellular region |
| Function |
| peptidase activity |
| hemoglobin binding |
| peptidase activity, acting on l-amino acid peptides |
| endopeptidase activity |
| serine-type endopeptidase activity |
| binding |
| catalytic activity |
| hydrolase activity |
| protein binding |
| Process |
| metabolic process |
| macromolecule metabolic process |
| protein metabolic process |
| proteolysis |
|
| Cellular Location
|
- Secreted
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 16q22.1 |
| SNPs
| HP |
| Gene Sequence
|
>1221 bp
ATGAGTGCCCTGGGAGCTGTCATTGCCCTCCTGCTCTGGGGACAGCTTTTTGCAGTGGAC
TCAGGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCA
CATGGCTATGTGGAGCACTCGGTTCGCTACCAGTGTAAGAACTACTACAAACTGCGCACA
GAAGGAGATGGAGTATACACCTTAAATAATAAGAAGCAGTGGATAAATAAGGCTGTTGGA
GATAAACTTCCTGAATGTGAAGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACAT
GGCTATGTGGAGCACTCGGTCCGCTACCAGTGTAAGAACTACTACAAACTGCGCACAGAA
GGAGATGGAGTGTACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGAT
AAACTTCCTGAATGTGAAGCAGTATGTGGGAAGCCCAAGAATCCGGCAAACCCAGTGCAG
CGGATCCTAGGTGGACACCTTGATGCCAAAGGCAGCTTTCCCTGGCAGGCTAAGATGGTT
TCCCACCATAATCTCACCACAGGTGCCACGCTGATCAATGAACAATGGCTGCTGACCACG
GCTAAAAATCTCTTCCTGAACCATTCAGAAAATGCAACAGCGAAAGACATTGCCCCTACT
TTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATTGAGAAGGTTGTTCTACACCCT
AACTACTCCCAGGTAGATATTGGGCTCATCAAACTCAAACAGAAGGTGTCTGTTAATGAG
AGAGTGATGCCCATCTGCCTACCTTCAAAGGATTATGCAGAAGTAGGGCGTGTGGGTTAT
GTTTCTGGCTGGGGGCGAAATGCCAATTTTAAATTTACTGACCATCTGAAGTATGTCATG
CTGCCTGTGGCTGACCAAGACCAATGCATAAGGCATTATGAAGGCAGCACAGTCCCCGAA
AAGAAGACACCGAAGAGCCCTGTAGGGGTGCAGCCCATACTGAATGAACACACCTTCTGT
GCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGCGATGCGGGCAGTGCCTTTGCC
GTTCACGACCTGGAGGAGGACACCTGGTATGCGACTGGGATCTTAAGCTTTGATAAGAGC
TGTGCTGTGGCTGAGTATGGTGTGTATGTGAAGGTGACTTCCATCCAGGACTGGGTTCAG
AAGACCATAGCTGAGAACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 406 |
| Molecular Weight
| 45205.1 |
| Theoretical pI
| 6.56 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Haptoglobin
MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRT
EGDGVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTE
GDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMV
SHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHP
NYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVM
LPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFA
VHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN
|
| External Links |
|---|
| GenBank ID Protein
| 306882 |
| UniProtKB/Swiss-Prot ID
| P00738 |
| UniProtKB/Swiss-Prot Entry Name
| HPT_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| K00422 |
| GeneCard ID
| HP |
| GenAtlas ID
| HP |
| HGNC ID
| HGNC:5141 |
| References |
|---|
| General References
| Not Available |