| Identification |
|---|
| HMDB Protein ID
| CDBP01906 |
| Secondary Accession Numbers
| Not Available |
| Name
| Aprataxin |
| Description
| Not Available |
| Synonyms
|
- FHA-HIT
- Forkhead-associated domain histidine triad-like protein
|
| Gene Name
| APTX |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non- ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'- monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| transition metal ion binding |
| zinc ion binding |
|
| Cellular Location
|
- Nucleus
- Nucleus
- nucleolus
- nucleoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:9 |
| Locus
| 9p13.3 |
| SNPs
| APTX |
| Gene Sequence
|
>1071 bp
ATGAGTAACGTGAATTTGTCCGTCTCCGACTTCTGGAGAGTGATGATGCGGGTGTGCTGG
TTGGTGAGACAGGACAGCCGGCACCAGCGAATCAGACTTCCACATTTGGAAGCAGTTGTG
ATTGGGCGTGGCCCAGAGACCAAGATCACTGATAAGAAATGTTCTCGACAGCAAGTACAG
TTGAAAGCAGAGTGTAACAAGGGATATGTCAAGGTAAAGCAGGTAGGAGTCAATCCCACC
AGCATTGACTCAGTCGTAATTGGGAAGGACCAAGAGGTGAAGCTGCAGCCTGGCCAGGTT
CTCCACATGGTGAATGAACTTTATCCATATATTGTAGAGTTTGAGGAAGAGGCAAAGAAC
CCTGGCCTGGAAACACACAGGAAGAGAAAGAGATCAGGCAACAGTGATTCTATAGAAAGG
GATGCTGCTCAGGAAGCTGAGGCTGGGACAGGGCTGGAACCTGGGAGCAACTCTGGCCAA
TGCTCTGTGCCCCTAAAGAAGGGAAAAGATGCACCTATCAAAAAGGAATCCCTGGGCCAC
TGGAGTCAAGGCTTGAAGATTTCTATGCAGGACCCCAAAATGCAGGTTTACAAAGATGAG
CAGGTGGTGGTGATAAAGGATAAATACCCAAAGGCCCGTTACCATTGGCTGGTCTTACCG
TGGACCTCCATTTCCAGTCTGAAGGCTGTGGCCAGGGAACACCTTGAACTCCTTAAGCAT
ATGCACACTGTGGGGGAAAAGGTGATTGTAGATTTTGCTGGGTCCAGCAAACTCCGCTTC
CGATTGGGCTACCACGCCATTCCGAGTATGAGCCATGTACATCTTCATGTGATCAGCCAG
GATTTTGATTCTCCTTGCCTTAAAAACAAAAAACATTGGAATTCTTTCAATACAGAATAC
TTCCTAGAATCACAAGCTGTGATCGAGATGGTACAAGAGGCTGGTAGAGTAACTGTCCGA
GATGGGATGCCTGAGCTCTTGAAGCTGCCCCTTCGTTGTCATGAGTGCCAGCAGCTGCTG
CCTTCCATTCCTCAGCTGAAAGAACATCTCAGGAAGCACTGGACACAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 356 |
| Molecular Weight
| 40739.8 |
| Theoretical pI
| 9.68 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Aprataxin
MSNVNLSVSDFWRVMMRVCWLVRQDSRHQRIRLPHLEAVVIGRGPETKITDKKCSRQQVQ
LKAECNKGYVKVKQVGVNPTSIDSVVIGKDQEVKLQPGQVLHMVNELYPYIVEFEEEAKN
PGLETHRKRKRSGNSDSIERDAAQEAEAGTGLEPGSNSGQCSVPLKKGKDAPIKKESLGH
WSQGLKISMQDPKMQVYKDEQVVVIKDKYPKARYHWLVLPWTSISSLKAVAREHLELLKH
MHTVGEKVIVDFAGSSKLRFRLGYHAIPSMSHVHLHVISQDFDSPCLKNKKHWNSFNTEY
FLESQAVIEMVQEAGRVTVRDGMPELLKLPLRCHECQQLLPSIPQLKEHLRKHWTQ
|
| External Links |
|---|
| GenBank ID Protein
| 305410829 |
| UniProtKB/Swiss-Prot ID
| Q7Z2E3 |
| UniProtKB/Swiss-Prot Entry Name
| APTX_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001195248.1 |
| GeneCard ID
| APTX |
| GenAtlas ID
| APTX |
| HGNC ID
| HGNC:15984 |
| References |
|---|
| General References
| Not Available |