| Identification |
|---|
| HMDB Protein ID
| CDBP01899 |
| Secondary Accession Numbers
| Not Available |
| Name
| Major prion protein |
| Description
| Not Available |
| Synonyms
|
- ASCR
- CD230 antigen
- PrP
- PrP27-30
- PrP33-35C
|
| Gene Name
| PRNP |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein homooligomerization |
| Specific Function
| The function of PrP is still under debate. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Isoform 2 may act as a growth suppressor by arresting the cell cycle at the G0/G1 phase. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Process |
| cellular component organization or biogenesis |
| cellular component organization |
| cellular component assembly |
| macromolecular complex assembly |
| protein complex assembly |
| protein oligomerization |
| protein homooligomerization |
|
| Cellular Location
|
- Nucleus
- Isoform 2:Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 20p13 |
| SNPs
| PRNP |
| Gene Sequence
|
>762 bp
ATGGCGAACCTTGGCTGCTGGATGCTGGTTCTCTTTGTGGCCACATGGAGTGACCTGGGC
CTCTGCAAGAAGCGCCCGAAGCCTGGAGGATGGAACACTGGGGGCAGCCGATACCCGGGG
CAGGGCAGCCCTGGAGGCAACCGCTACCCACCTCAGGGCGGTGGTGGCTGGGGGCAGCCT
CATGGTGGTGGCTGGGGGCAGCCTCATGGTGGTGGCTGGGGGCAGCCCCATGGTGGTGGC
TGGGGACAGCCTCATGGTGGTGGCTGGGGTCAAGGAGGTGGCACCCACAGTCAGTGGAAC
AAGCCGAGTAAGCCAAAAACCAACATGAAGCACATGGCTGGTGCTGCAGCAGCTGGGGCA
GTGGTGGGGGGCCTTGGCGGCTACATGCTGGGAAGTGCCATGAGCAGGCCCATCATACAT
TTCGGCAGTGACTATGAGGACCGTTACTATCGTGAAAACATGCACCGTTACCCCAACCAA
GTGTACTACAGGCCCATGGATGAGTACAGCAACCAGAACAACTTTGTGCACGACTGCGTC
AATATCACAATCAAGCAGCACACGGTCACCACAACCACCAAGGGGGAGAACTTCACCGAG
ACCGACGTTAAGATGATGGAGCGCGTGGTTGAGCAGATGTGTATCACCCAGTACGAGAGG
GAATCTCAGGCCTATTACCAGAGAGGATCGAGCATGGTCCTCTTCTCCTCTCCACCTGTG
ATCCTCCTGATCTCTTTCCTCATCTTCCTGATAGTGGGATGA
|
| Protein Properties |
|---|
| Number of Residues
| 253 |
| Molecular Weight
| 27661.2 |
| Theoretical pI
| 9.23 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Major prion protein
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQP
HGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGA
VVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCV
NITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPV
ILLISFLIFLIVG
|
| External Links |
|---|
| GenBank ID Protein
| 190468 |
| UniProtKB/Swiss-Prot ID
| P04156 |
| UniProtKB/Swiss-Prot Entry Name
| PRIO_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| M13899 |
| GeneCard ID
| PRNP |
| GenAtlas ID
| PRNP |
| HGNC ID
| HGNC:9449 |
| References |
|---|
| General References
| Not Available |