| Identification |
|---|
| HMDB Protein ID
| CDBP01887 |
| Secondary Accession Numbers
| Not Available |
| Name
| Folate receptor alpha |
| Description
| Not Available |
| Synonyms
|
- Adult folate-binding protein
- FBP
- FR-alpha
- Folate receptor 1
- Folate receptor, adult
- KB cells FBP
- Ovarian tumor-associated antigen MOv18
|
| Gene Name
| FOLR1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in folic acid binding |
| Specific Function
| Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Cell membrane
- Lipid-anchor
- GPI-anchor
- Secreted (Probable)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11q13.3-q14.1 |
| SNPs
| FOLR1 |
| Gene Sequence
|
>774 bp
ATGGCTCAGCGGATGACAACACAGCTGCTGCTCCTTCTAGTGTGGGTGGCTGTAGTAGGG
GAGGCTCAGACAAGGATTGCATGGGCCAGGACTGAGCTTCTCAATGTCTGCATGAACGCC
AAGCACCACAAGGAAAAGCCAGGCCCCGAGGACAAGTTGCATGAGCAGTGTCGACCCTGG
AGGAAGAATGCCTGCTGTTCTACCAACACCAGCCAGGAAGCCCATAAGGATGTTTCCTAC
CTATATAGATTCAACTGGAACCACTGTGGAGAGATGGCACCTGCCTGCAAACGGCATTTC
ATCCAGGACACCTGCCTCTACGAGTGCTCCCCCAACTTGGGGCCCTGGATCCAGCAGGTG
GATCAGAGCTGGCGCAAAGAGCGGGTACTGAACGTGCCCCTGTGCAAAGAGGACTGTGAG
CAATGGTGGGAAGATTGTCGCACCTCCTACACCTGCAAGAGCAACTGGCACAAGGGCTGG
AACTGGACTTCAGGGTTTAACAAGTGCGCAGTGGGAGCTGCCTGCCAACCTTTCCATTTC
TACTTCCCCACACCCACTGTTCTGTGCAATGAAATCTGGACTCACTCCTACAAGGTCAGC
AACTACAGCCGAGGGAGTGGCCGCTGCATCCAGATGTGGTTCGACCCAGCCCAGGGCAAC
CCCAATGAGGAGGTGGCGAGGTTCTATGCTGCAGCCATGAGTGGGGCTGGGCCCTGGGCA
GCCTGGCCTTTCCTGCTTAGCCTGGCCCTAATGCTGCTGTGGCTGCTCAGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 257 |
| Molecular Weight
| 29818.9 |
| Theoretical pI
| 8.02 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Folate receptor alpha
MAQRMTTQLLLLLVWVAVVGEAQTRIAWARTELLNVCMNAKHHKEKPGPEDKLHEQCRPW
RKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQV
DQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHF
YFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAAAMSGAGPWA
AWPFLLSLALMLLWLLS
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P15328 |
| UniProtKB/Swiss-Prot Entry Name
| FOLR1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| J05013 |
| GeneCard ID
| FOLR1 |
| GenAtlas ID
| FOLR1 |
| HGNC ID
| HGNC:3791 |
| References |
|---|
| General References
| Not Available |