Showing Protein Solute carrier family 40 member 1 (CDBP01886)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP01886
Secondary Accession Numbers Not Available
Name Solute carrier family 40 member 1
Description Not Available
Synonyms
  1. Ferroportin-1
  2. Iron-regulated transporter 1
Gene Name SLC40A1
Protein Type Transporter
Biological Properties
General Function Involved in iron ion transmembrane transporter activity
Specific Function May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin)
GO Classification
Component
intrinsic to membrane
integral to membrane
cell part
membrane part
Function
di-, tri-valent inorganic cation transmembrane transporter activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
cation transmembrane transporter activity
inorganic cation transmembrane transporter activity
iron ion transmembrane transporter activity
transporter activity
Process
iron ion transport
establishment of localization
transport
ion transport
cation transport
metal ion transport
transition metal ion transport
Cellular Location
  1. Cell membrane
  2. Multi-pass membrane protein
Pathways
Gene Properties
Chromosome Location Chromosome:2
Locus 2q32
SNPs SLC40A1
Gene Sequence 
>1716 bp
ATGACCAGGGCGGGAGATCACAACCGCCAGAGAGGATGCTGTGGATCCTTGGCCGACTAC
CTGACCTCTGCAAAATTCCTTCTCTACCTTGGTCATTCTCTCTCTACTTGGGGAGATCGG
ATGTGGCACTTTGCGGTGTCTGTGTTTCTGGTAGAGCTCTATGGAAACAGCCTCCTTTTG
ACAGCAGTCTACGGGCTGGTGGTGGCAGGGTCTGTTCTGGTCCTGGGAGCCATCATCGGT
GACTGGGTGGACAAGAATGCTAGACTTAAAGTGGCCCAGACCTCGCTGGTGGTACAGAAT
GTTTCAGTCATCCTGTGTGGAATCATCCTGATGATGGTTTTCTTACATAAACATGAGCTT
CTGACCATGTACCATGGATGGGTTCTCACTTCCTGCTATATCCTGATCATCACTATTGCA
AATATTGCAAATTTGGCCAGTACTGCTACTGCAATCACAATCCAAAGGGATTGGATTGTT
GTTGTTGCAGGAGAAGACAGAAGCAAACTAGCAAATATGAATGCCACAATACGAAGGATT
GACCAGTTAACCAACATCTTAGCCCCCATGGCTGTTGGCCAGATTATGACATTTGGCTCC
CCAGTCATCGGCTGTGGCTTTATTTCGGGATGGAACTTGGTATCCATGTGCGTGGAGTAC
GTTCTGCTCTGGAAGGTTTACCAGAAAACCCCAGCTCTAGCTGTGAAAGCTGGTCTTAAA
GAAGAGGAAACTGAATTGAAACAGCTGAATTTACACAAAGATACTGAGCCAAAACCCCTG
GAGGGAACTCATCTAATGGGTGTGAAAGACTCTAACATCCATGAGCTTGAACATGAGCAA
GAGCCTACTTGTGCCTCCCAGATGGCTGAGCCCTTCCGTACCTTCCGAGATGGATGGGTC
TCCTACTACAACCAGCCTGTGTTTCTGGCTGGCATGGGTCTTGCTTTCCTTTATATGACT
GTCCTGGGCTTTGACTGCATCACCACAGGGTACGCCTACACTCAGGGACTGAGTGGTTCC
ATCCTCAGTATTTTGATGGGAGCATCAGCTATAACTGGAATAATGGGAACTGTAGCTTTT
ACTTGGCTACGTCGAAAATGTGGTTTGGTTCGGACAGGTCTGATCTCAGGATTGGCACAG
CTTTCCTGTTTGATCTTGTGTGTGATCTCTGTATTCATGCCTGGAAGCCCCCTGGACTTG
TCCGTTTCTCCTTTTGAAGATATCCGATCAAGGTTCATTCAAGGAGAGTCAATTACACCT
ACCAAGATACCTGAAATTACAACTGAAATATACATGTCTAATGGGTCTAATTCTGCTAAT
ATTGTCCCGGAGACAAGTCCTGAATCTGTGCCCATAATCTCTGTCAGTCTGCTGTTTGCA
GGCGTCATTGCTGCTAGAATCGGTCTTTGGTCCTTTGATTTAACTGTGACACAGTTGCTG
CAAGAAAATGTAATTGAATCTGAAAGAGGCATTATAAATGGTGTACAGAACTCCATGAAC
TATCTTCTTGATCTTCTGCATTTCATCATGGTCATCCTGGCTCCAAATCCTGAAGCTTTT
GGCTTGCTCGTATTGATTTCAGTCTCCTTTGTGGCAATGGGCCACATTATGTATTTCCGA
TTTGCCCAAAATACTCTGGGAAACAAGCTCTTTGCTTGCGGTCCTGATGCAAAAGAAGTT
AGGAAGGAAAATCAAGCAAATACATCTGTTGTTTGA
Protein Properties
Number of Residues 571
Molecular Weight 62541.6
Theoretical pI 6.5
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["12-34", "58-80", "93-115", "125-147", "299-321", "341-363", "370-392", "450-472", "492-514", "519-541"]
Protein Sequence 
>Solute carrier family 40 member 1
MTRAGDHNRQRGCCGSLADYLTSAKFLLYLGHSLSTWGDRMWHFAVSVFLVELYGNSLLL
TAVYGLVVAGSVLVLGAIIGDWVDKNARLKVAQTSLVVQNVSVILCGIILMMVFLHKHEL
LTMYHGWVLTSCYILIITIANIANLASTATAITIQRDWIVVVAGEDRSKLANMNATIRRI
DQLTNILAPMAVGQIMTFGSPVIGCGFISGWNLVSMCVEYVLLWKVYQKTPALAVKAGLK
EEETELKQLNLHKDTEPKPLEGTHLMGVKDSNIHELEHEQEPTCASQMAEPFRTFRDGWV
SYYNQPVFLAGMGLAFLYMTVLGFDCITTGYAYTQGLSGSILSILMGASAITGIMGTVAF
TWLRRKCGLVRTGLISGLAQLSCLILCVISVFMPGSPLDLSVSPFEDIRSRFIQGESITP
TKIPEITTEIYMSNGSNSANIVPETSPESVPIISVSLLFAGVIAARIGLWSFDLTVTQLL
QENVIESERGIINGVQNSMNYLLDLLHFIMVILAPNPEAFGLLVLISVSFVAMGHIMYFR
FAQNTLGNKLFACGPDAKEVRKENQANTSVV
GenBank ID Protein 7657100
UniProtKB/Swiss-Prot ID Q9NP59
UniProtKB/Swiss-Prot Entry Name S40A1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_014585.5
GeneCard ID SLC40A1
GenAtlas ID SLC40A1
HGNC ID HGNC:10909
References
General References Not Available