| Identification |
|---|
| HMDB Protein ID
| CDBP01852 |
| Secondary Accession Numbers
| Not Available |
| Name
| Vitamin K epoxide reductase complex subunit 1 |
| Description
| Not Available |
| Synonyms
|
- Vitamin K1 2,3-epoxide reductase subunit 1
|
| Gene Name
| VKORC1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in vitamin-K-epoxide reductase (warfarin-sensi |
| Specific Function
| Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K.
|
| GO Classification
|
| Biological Process |
| drug metabolic process |
| post-translational protein modification |
| peptidyl-glutamic acid carboxylation |
| Cellular Component |
| endoplasmic reticulum membrane |
| integral to membrane |
| Molecular Function |
| vitamin-K-epoxide reductase (warfarin-sensitive) activity |
|
| Cellular Location
|
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Vitamin K Metabolism |    | Not Available | | Ubiquinone and other terpenoid-quinone biosynthesis | Not Available |  | | Acenocoumarol Action Pathway |    | Not Available | | Coagulation |    | Not Available | | Enoxaparin Action Pathway |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| 16p11.2 |
| SNPs
| VKORC1 |
| Gene Sequence
|
>492 bp
ATGGGCAGCACCTGGGGGAGCCCTGGCTGGGTGCGGCTCGCTCTTTGCCTGACGGGCTTA
GTGCTCTCGCTCTACGCGCTGCACGTGAAGGCGGCGCGCGCCCGGGACCGGGATTACCGC
GCGCTCTGCGACGTGGGCACCGCCATCAGCTGTTCGCGCGTCTTCTCCTCCAGGTGGGGC
AGGGGTTTCGGGCTGGTGGAGCATGTGCTGGGACAGGACAGCATCCTCAATCAATCCAAC
AGCATATTCGGTTGCATCTTCTACACACTACAGCTATTGTTAGGTTGCCTGCGGACACGC
TGGGCCTCTGTCCTGATGCTGCTGAGCTCCCTGGTGTCTCTCGCTGGTTCTGTCTACCTG
GCCTGGATCCTGTTCTTCGTGCTCTATGATTTCTGCATTGTTTGTATCACCACCTATGCT
ATCAACGTGAGCCTGATGTGGCTCAGTTTCCGGAAGGTCCAAGAACCCCAGGGCAAGGCT
AAGAGGCACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 163 |
| Molecular Weight
| 18234.3 |
| Theoretical pI
| 9.361 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Vitamin K epoxide reductase complex subunit 1
MGSTWGSPGWVRLALCLTGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRWG
RGFGLVEHVLGQDSILNQSNSIFGCIFYTLQLLLGCLRTRWASVLMLLSSLVSLAGSVYL
AWILFFVLYDFCIVCITTYAINVSLMWLSFRKVQEPQGKAKRH
|
| External Links |
|---|
| GenBank ID Protein
| 40217983 |
| UniProtKB/Swiss-Prot ID
| Q9BQB6 |
| UniProtKB/Swiss-Prot Entry Name
| VKOR1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY423044 |
| GeneCard ID
| VKORC1 |
| GenAtlas ID
| VKORC1 |
| HGNC ID
| HGNC:23663 |
| References |
|---|
| General References
| Not Available |