| Identification |
|---|
| HMDB Protein ID
| CDBP01846 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cocaine- and amphetamine-regulated transcript protein |
| Description
| Not Available |
| Synonyms
|
- CART(1-39)
- CART(42-89)
|
| Gene Name
| CARTPT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in vitro |
| GO Classification
|
| Component |
| extracellular region part |
| extracellular space |
| Function |
| protein binding |
| binding |
| Process |
| phosphorylation |
| response to extracellular stimulus |
| phosphorus metabolic process |
| regulation of biological quality |
| response to nutrient levels |
| phosphate metabolic process |
| homeostatic process |
| cellular response to nutrient levels |
| response to stimulus |
| chemical homeostasis |
| cellular response to starvation |
| metabolic process |
| behavior |
| biological regulation |
| feeding behavior |
| regulation of biological process |
| adult feeding behavior |
| cellular metabolic process |
| carbohydrate homeostasis |
| regulation of response to stimulus |
| glucose homeostasis |
| regulation of response to external stimulus |
| cellular glucose homeostasis |
| activation of mapkk activity |
| regulation of response to extracellular stimulus |
| protein amino acid phosphorylation |
| regulation of response to nutrient levels |
| signaling |
| regulation of response to food |
| signaling pathway |
| negative regulation of response to food |
| cell surface receptor linked signaling pathway |
| negative regulation of appetite |
| g-protein coupled receptor protein signaling pathway |
| response to external stimulus |
|
| Cellular Location
|
- Secreted (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q13.2 |
| SNPs
| CARTPT |
| Gene Sequence
|
>351 bp
ATGGAGAGCTCCCGCGTGAGGCTGCTGCCCCTCCTGGGCGCCGCCCTGCTGCTGATGCTA
CCTCTGTTGGGTACCCGTGCCCAGGAGGACGCCGAGCTCCAGCCCCGAGCCCTGGACATC
TACTCTGCCGTGGATGATGCCTCCCACGAGAAGGAGCTGATCGAAGCGCTGCAAGAAGTC
TTGAAGAAGCTCAAGAGTAAACGTGTTCCCATCTATGAGAAGAAGTATGGCCAAGTCCCC
ATGTGTGACGCCGGTGAGCAGTGTGCAGTGAGGAAAGGGGCAAGGATCGGGAAGCTGTGT
GACTGTCCCCGAGGAACCTCCTGCAATTCCTTCCTCCTGAAGTGCTTATGA
|
| Protein Properties |
|---|
| Number of Residues
| 116 |
| Molecular Weight
| 12829.0 |
| Theoretical pI
| 8.37 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cocaine- and amphetamine-regulated transcript protein
MESSRVRLLPLLGAALLLMLPLLGTRAQEDAELQPRALDIYSAVDDASHEKELIEALQEV
LKKLKSKRVPIYEKKYGQVPMCDAGEQCAVRKGARIGKLCDCPRGTSCNSFLLKCL
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q16568 |
| UniProtKB/Swiss-Prot Entry Name
| CART_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| U16826 |
| GeneCard ID
| CARTPT |
| GenAtlas ID
| CARTPT |
| HGNC ID
| HGNC:24323 |
| References |
|---|
| General References
| Not Available |