Showing Protein Glial cell line-derived neurotrophic factor (CDBP01826)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 compounds
Identification
HMDB Protein ID CDBP01826
Secondary Accession Numbers Not Available
Name Glial cell line-derived neurotrophic factor
Description Not Available
Synonyms
  1. ATF
  2. Astrocyte-derived trophic factor
  3. hGDNF
Gene Name GDNF
Protein Type Receptor
Biological Properties
General Function Involved in growth factor activity
Specific Function Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake
GO Classification
Function
binding
protein binding
receptor binding
growth factor activity
Cellular Location
  1. Secreted
Pathways
Gene Properties
Chromosome Location Chromosome:5
Locus 5p13.1-p12
SNPs GDNF
Gene Sequence 
>636 bp
ATGAAGTTATGGGATGTCGTGGCTGTCTGCCTGGTGCTGCTCCACACCGCGTCCGCCTTC
CCGCTGCCCGCCGGTAAGAGGCCTCCCGAGGCGCCCGCCGAAGACCGCTCCCTCGGCCGC
CGCCGCGCGCCCTTCGCGCTGAGCAGTGACTCAAATATGCCAGAGGATTATCCTGATCAG
TTCGATGATGTCATGGATTTTATTCAAGCCACCATTAAAAGACTGAAAAGGTCACCAGAT
AAACAAATGGCAGTGCTTCCTAGAAGAGAGCGGAATCGGCAGGCTGCAGCTGCCAACCCA
GAGAATTCCAGAGGAAAAGGTCGGAGAGGCCAGAGGGGCAAAAACCGGGGTTGTGTCTTA
ACTGCAATACATTTAAATGTCACTGACTTGGGTCTGGGCTATGAAACCAAGGAGGAACTG
ATTTTTAGGTACTGCAGCGGCTCTTGCGATGCAGCTGAGACAACGTACGACAAAATATTG
AAAAACTTATCCAGAAATAGAAGGCTGGTGAGTGACAAAGTAGGGCAGGCATGTTGCAGA
CCCATCGCCTTTGATGATGACCTGTCGTTTTTAGATGATAACCTGGTTTACCATATTCTA
AGAAAGCATTCCGCTAAAAGGTGTGGATGTATCTGA
Protein Properties
Number of Residues 211
Molecular Weight 23719.8
Theoretical pI 9.34
Pfam Domain Function
Signals
  • ["1-19"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Glial cell line-derived neurotrophic factor
MKLWDVVAVCLVLLHTASAFPLPAGKRPPEAPAEDRSLGRRRAPFALSSDSNMPEDYPDQ
FDDVMDFIQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVL
TAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCR
PIAFDDDLSFLDDNLVYHILRKHSAKRCGCI
GenBank ID Protein 4503975
UniProtKB/Swiss-Prot ID P39905
UniProtKB/Swiss-Prot Entry Name GDNF_HUMAN
PDB IDs
GenBank Gene ID NM_000514.3
GeneCard ID GDNF
GenAtlas ID GDNF
HGNC ID HGNC:4232
References
General References Not Available