| Identification |
|---|
| HMDB Protein ID
| CDBP01820 |
| Secondary Accession Numbers
| Not Available |
| Name
| CD40 ligand |
| Description
| Not Available |
| Synonyms
|
- CD154 antigen
- CD40 ligand, membrane form
- CD40 ligand, soluble form
- CD40-L
- T-cell antigen Gp39
- TNF-related activation protein
- TRAP
- Tumor necrosis factor ligand superfamily member 5
|
| Gene Name
| CD40LG |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in tumor necrosis factor receptor binding |
| Specific Function
| Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Function |
| binding |
| cytokine receptor binding |
| tumor necrosis factor receptor superfamily binding |
| tumor necrosis factor receptor binding |
| protein binding |
| receptor binding |
| Process |
| immune system process |
| immune response |
|
| Cellular Location
|
- soluble form:Secreted
- CD40 ligand
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| CD40LG |
| Gene Sequence
|
>786 bp
ATGATCGAAACATACAACCAAACTTCTCCCCGATCTGCGGCCACTGGACTGCCCATCAGC
ATGAAAATTTTTATGTATTTACTTACTGTTTTTCTTATCACCCAGATGATTGGGTCAGCA
CTTTTTGCTGTGTATCTTCATAGAAGGCTGGACAAGATAGAAGATGAAAGGAATCTTCAT
GAAGATTTTGTATTCATGAAAACGATACAGAGATGCAACACAGGAGAAAGATCCTTATCC
TTACTGAACTGTGAGGAGATTAAAAGCCAGTTTGAAGGCTTTGTGAAGGATATAATGTTA
AACAAAGAGGAGACGAAGAAAGAAAACAGCTTTGAAATGCAAAAAGGTGATCAGAATCCT
CAAATTGCGGCACATGTCATAAGTGAGGCCAGCAGTAAAACAACATCTGTGTTACAGTGG
GCTGAAAAAGGATACTACACCATGAGCAACAACTTGGTAACCCTGGAAAATGGGAAACAG
CTGACCGTTAAAAGACAAGGACTCTATTATATCTATGCCCAAGTCACCTTCTGTTCCAAT
CGGGAAGCTTCGAGTCAAGCTCCATTTATAGCCAGCCTCTGCCTAAAGTCCCCCGGTAGA
TTCGAGAGAATCTTACTCAGAGCTGCAAATACCCACAGTTCCGCCAAACCTTGCGGGCAA
CAATCCATTCACTTGGGAGGAGTATTTGAATTGCAACCAGGTGCTTCGGTGTTTGTCAAT
GTGACTGATCCAAGCCAAGTGAGCCATGGCACTGGCTTCACGTCCTTTGGCTTACTCAAA
CTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 261 |
| Molecular Weight
| 29273.3 |
| Theoretical pI
| 8.46 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>CD40 ligand
MIETYNQTSPRSAATGLPISMKIFMYLLTVFLITQMIGSALFAVYLHRRLDKIEDERNLH
EDFVFMKTIQRCNTGERSLSLLNCEEIKSQFEGFVKDIMLNKEETKKENSFEMQKGDQNP
QIAAHVISEASSKTTSVLQWAEKGYYTMSNNLVTLENGKQLTVKRQGLYYIYAQVTFCSN
REASSQAPFIASLCLKSPGRFERILLRAANTHSSAKPCGQQSIHLGGVFELQPGASVFVN
VTDPSQVSHGTGFTSFGLLKL
|
| External Links |
|---|
| GenBank ID Protein
| 37270 |
| UniProtKB/Swiss-Prot ID
| P29965 |
| UniProtKB/Swiss-Prot Entry Name
| CD40L_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| X68550 |
| GeneCard ID
| CD40LG |
| GenAtlas ID
| CD40LG |
| HGNC ID
| HGNC:11935 |
| References |
|---|
| General References
| Not Available |