| Identification |
|---|
| HMDB Protein ID
| CDBP01819 |
| Secondary Accession Numbers
| Not Available |
| Name
| Caspase-1 |
| Description
| Not Available |
| Synonyms
|
- CASP-1
- Caspase-1 subunit p10
- Caspase-1 subunit p20
- ICE
- IL-1 beta-converting enzyme
- IL-1BC
- Interleukin-1 beta convertase
- Interleukin-1 beta-converting enzyme
- p45
|
| Gene Name
| CASP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| hydrolase activity |
| protein binding |
| peptidase activity |
| peptidase activity, acting on l-amino acid peptides |
| cysteine-type peptidase activity |
| endopeptidase activity |
| cysteine-type endopeptidase activity |
| binding |
| catalytic activity |
| Process |
| proteolysis |
| cell death |
| metabolic process |
| macromolecule metabolic process |
| cellular process |
| biological regulation |
| regulation of biological process |
| programmed cell death |
| apoptosis |
| regulation of cell death |
| regulation of programmed cell death |
| regulation of apoptosis |
| regulation of cellular process |
| protein metabolic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11q23 |
| SNPs
| CASP1 |
| Gene Sequence
|
>1215 bp
ATGGCCGACAAGGTCCTGAAGGAGAAGAGAAAGCTGTTTATCCGTTCCATGGGTGAAGGT
ACAATAAATGGCTTACTGGATGAATTATTACAGACAAGGGTGCTGAACAAGGAAGAGATG
GAGAAAGTAAAACGTGAAAATGCTACAGTTATGGATAAGACCCGAGCTTTGATTGACTCC
GTTATTCCGAAAGGGGCACAGGCATGCCAAATTTGCATCACATACATTTGTGAAGAAGAC
AGTTACCTGGCAGGGACGCTGGGACTCTCAGCAGATCAAACATCTGGAAATTACCTTAAT
ATGCAAGACTCTCAAGGAGTACTTTCTTCCTTTCCAGCTCCTCAGGCAGTGCAGGACAAC
CCAGCTATGCCCACATCCTCAGGCTCAGAAGGGAATGTCAAGCTTTGCTCCCTAGAAGAA
GCTCAAAGGATATGGAAACAAAAGTCGGCAGAGATTTATCCAATAATGGACAAGTCAAGC
CGCACACGTCTTGCTCTCATTATCTGCAATGAAGAATTTGACAGTATTCCTAGAAGAACT
GGAGCTGAGGTTGACATCACAGGCATGACAATGCTGCTACAAAATCTGGGGTACAGCGTA
GATGTGAAAAAAAATCTCACTGCTTCGGACATGACTACAGAGCTGGAGGCATTTGCACAC
CGCCCAGAGCACAAGACCTCTGACAGCACGTTCCTGGTGTTCATGTCTCATGGTATTCGG
GAAGGCATTTGTGGGAAGAAACACTCTGAGCAAGTCCCAGATATACTACAACTCAATGCA
ATCTTTAACATGTTGAATACCAAGAACTGCCCAAGTTTGAAGGACAAACCGAAGGTGATC
ATCATCCAGGCCTGCCGTGGTGACAGCCCTGGTGTGGTGTGGTTTAAAGATTCAGTAGGA
GTTTCTGGAAACCTATCTTTACCAACTACAGAAGAGTTTGAGGATGATGCTATTAAGAAA
GCCCACATAGAGAAGGATTTTATCGCTTTCTGCTCTTCCACACCAGATAATGTTTCTTGG
AGACATCCCACAATGGGCTCTGTTTTTATTGGAAGACTCATTGAACATATGCAAGAATAT
GCCTGTTCCTGTGATGTGGAGGAAATTTTCCGCAAGGTTCGATTTTCATTTGAGCAGCCA
GATGGTAGAGCGCAGATGCCCACCACTGAAAGAGTGACTTTGACAAGATGTTTCTACCTC
TTCCCAGGACATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 404 |
| Molecular Weight
| 45158.2 |
| Theoretical pI
| 5.71 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Caspase-1
MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN
PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR
EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG
VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY
ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
|
| External Links |
|---|
| GenBank ID Protein
| 33793 |
| UniProtKB/Swiss-Prot ID
| P29466 |
| UniProtKB/Swiss-Prot Entry Name
| CASP1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| X65019 |
| GeneCard ID
| CASP1 |
| GenAtlas ID
| CASP1 |
| HGNC ID
| HGNC:1499 |
| References |
|---|
| General References
| Not Available |