| Identification |
|---|
| HMDB Protein ID
| CDBP01818 |
| Secondary Accession Numbers
| Not Available |
| Name
| Connective tissue growth factor |
| Description
| Not Available |
| Synonyms
|
- CCN family member 2
- Hypertrophic chondrocyte-specific protein 24
- IBP-8
- IGF-binding protein 8
- IGFBP-8
- Insulin-like growth factor-binding protein 8
|
| Gene Name
| CTGF |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in insulin-like growth factor binding |
| Specific Function
| Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis |
| GO Classification
|
| Component |
| extracellular region |
| Function |
| binding |
| growth factor binding |
| insulin-like growth factor binding |
| protein binding |
| Process |
| regulation of growth |
| regulation of cell growth |
| biological regulation |
| regulation of biological process |
|
| Cellular Location
|
- Secreted
- Secreted
- extracellular space
- extracellular matrix
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:6 |
| Locus
| 6q23.1 |
| SNPs
| CTGF |
| Gene Sequence
|
>1050 bp
ATGACCGCCGCCAGTATGGGCCCCGTCCGCGTCGCCTTCGTGGTCCTCCTCGCCCTCTGC
AGCCGGCCGGCCGTCGGCCAGAACTGCAGCGGGCCGTGCCGGTGCCCGGACGAGCCGGCG
CCGCGCTGCCCGGCGGGCGTGAGCCTCGTGCTGGACGGCTGCGGCTGCTGCCGCGTCTGC
GCCAAGCAGCTGGGCGAGCTGTGCACCGAGCGCGACCCCTGCGACCCGCACAAGGGCCTC
TTCTGTGACTTCGGCTCCCCGGCCAACCGCAAGATCGGCGTGTGCACCGCCAAAGATGGT
GCTCCCTGCATCTTCGGTGGTACGGTGTACCGCAGCGGAGAGTCCTTCCAGAGCAGCTGC
AAGTACCAGTGCACGTGCCTGGACGGGGCGGTGGGCTGCATGCCCCTGTGCAGCATGGAC
GTTCGTCTGCCCAGCCCTGACTGCCCCTTCCCGAGGAGGGTCAAGCTGCCCGGGAAATGC
TGCGAGGAGTGGGTGTGTGACGAGCCCAAGGACCAAACCGTGGTTGGGCCTGCCCTCGCG
GCTTACCGACTGGAAGACACGTTTGGCCCAGACCCAACTATGATTAGAGCCAACTGCCTG
GTCCAGACCACAGAGTGGAGCGCCTGTTCCAAGACCTGTGGGATGGGCATCTCCACCCGG
GTTACCAATGACAACGCCTCCTGCAGGCTAGAGAAGCAGAGCCGCCTGTGCATGGTCAGG
CCTTGCGAAGCTGACCTGGAAGAGAACATTAAGAAGGGCAAAAAGTGCATCCGTACTCCC
AAAATCTCCAAGCCTATCAAGTTTGAGCTTTCTGGCTGCACCAGCATGAAGACATACCGA
GCTAAATTCTGTGGAGTATGTACCGACGGCCGATGCTGCACCCCCCACAGAACCACCACC
CTGCCGGTGGAGTTCAAGTGCCCTGACGGCGAGGTCATGAAGAAGAACATGATGTTCATC
AAGACCTGTGCCTGCCATTACAACTGTCCCGGAGACAATGACATCTTTGAATCGCTGTAC
TACAGGAAGATGTACGGAGACATGGCATGA
|
| Protein Properties |
|---|
| Number of Residues
| 349 |
| Molecular Weight
| 38091.0 |
| Theoretical pI
| 8.03 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Connective tissue growth factor
MTAASMGPVRVAFVVLLALCSRPAVGQNCSGPCRCPDEPAPRCPAGVSLVLDGCGCCRVC
AKQLGELCTERDPCDPHKGLFCHFGSPANRKIGVCTAKDGAPCIFGGTVYRSGESFQSSC
KYQCTCLDGAVGCMPLCSMDVRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDQTVVGPALA
AYRLEDTFGPDPTMIRANCLVQTTEWSACSKTCGMGISTRVTNDNASCRLEKQSRLCMVR
PCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSMKTYRAKFCGVCTDGRCCTPHRTTT
LPVEFKCPDGEVMKKNMMFIKTCACHYNCPGDNDIFESLYYRKMYGDMA
|
| External Links |
|---|
| GenBank ID Protein
| 4503123 |
| UniProtKB/Swiss-Prot ID
| P29279 |
| UniProtKB/Swiss-Prot Entry Name
| CTGF_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001901.2 |
| GeneCard ID
| CTGF |
| GenAtlas ID
| CTGF |
| HGNC ID
| HGNC:2500 |
| References |
|---|
| General References
| Not Available |