| Identification |
|---|
| HMDB Protein ID
| CDBP01817 |
| Secondary Accession Numbers
| Not Available |
| Name
| N-formyl peptide receptor 2 |
| Description
| Not Available |
| Synonyms
|
- FMLP-R-I
- FMLP-related receptor I
- Formyl peptide receptor-like 1
- HM63
- LXA4 receptor
- Lipoxin A4 receptor
- RFP
|
| Gene Name
| FPR2 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor protein signaling pathway |
| Specific Function
| Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4) |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| receptor activity |
| n-formyl peptide receptor activity |
| molecular transducer activity |
| signal transducer activity |
| peptide receptor activity |
| peptide receptor activity, g-protein coupled |
| Process |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| g-protein coupled receptor protein signaling pathway |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19q13.3-q13.4 |
| SNPs
| FPR2 |
| Gene Sequence
|
>1056 bp
ATGGAAACCAACTTCTCCACTCCTCTGAATGAATATGAAGAAGTGTCCTATGAGTCTGCT
GGCTACACTGTTCTGCGGATCCTCCCATTGGTGGTGCTTGGGGTCACCTTTGTCCTCGGG
GTCCTGGGCAATGGGCTTGTGATCTGGGTGGCTGGATTCCGGATGACACGCACAGTCACC
ACCATCTGTTACCTGAACCTGGCCCTGGCTGACTTTTCTTTCACGGCCACATTACCATTC
CTCATTGTCTCCATGGCCATGGGAGAAAAATGGCCTTTTGGCTGGTTCCTGTGTAAGTTA
ATTCACATCGTGGTGGACATCAACCTCTTTGGAAGTGTCTTCTTGATTGGTTTCATTGCA
CTGGACCGCTGCATTTGTGTCCTGCATCCAGTCTGGGCCCAGAACCACCGCACTGTGAGT
CTGGCCATGAAGGTGATCGTCGGACCTTGGATTCTTGCTCTAGTCCTTACCTTGCCAGTT
TTCCTCTTTTTGACTACAGTAACTATTCCAAATGGGGACACATACTGTACTTTCAACTTT
GCATCCTGGGGTGGCACCCCTGAGGAGAGGCTGAAGGTGGCCATTACCATGCTGACAGCC
AGAGGGATTATCCGGTTTGTCATTGGCTTTAGCTTGCCGATGTCCATTGTTGCCATCTGC
TATGGGCTCATTGCAGCCAAGATCCACAAAAAGGGCATGATTAAATCCAGCCGTCCCTTA
CGGGTCCTCACTGCTGTGGTGGCTTCTTTCTTCATCTGTTGGTTTCCCTTTCAACTGGTT
GCCCTTCTGGGCACCGTCTGGCTCAAAGAGATGTTGTTCTATGGCAAGTACAAAATCATT
GACATCCTGGTTAACCCAACGAGCTCCCTGGCCTTCTTCAACAGCTGCCTCAACCCCATG
CTTTACGTCTTTGTGGGCCAAGACTTCCGAGAGAGACTGATCCACTCCCTGCCCACCAGT
CTGGAGAGGGCCCTGTCTGAGGACTCAGCCCCAACTAATGACACGGCTGCCAATTCTGCT
TCACCTCCTGCAGAGACTGAGTTACAGGCAATGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 351 |
| Molecular Weight
| 38963.8 |
| Theoretical pI
| 7.99 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["28-50", "62-83", "101-121", "141-162", "206-226", "243-266", "287-306"]
|
| Protein Sequence
|
>N-formyl peptide receptor 2
METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVT
TICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIA
LDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNF
ASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPL
RVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPM
LYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
|
| External Links |
|---|
| GenBank ID Protein
| 9454518 |
| UniProtKB/Swiss-Prot ID
| P25090 |
| UniProtKB/Swiss-Prot Entry Name
| FPR2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AC018755 |
| GeneCard ID
| FPR2 |
| GenAtlas ID
| FPR2 |
| HGNC ID
| HGNC:3827 |
| References |
|---|
| General References
| Not Available |