| Identification |
|---|
| HMDB Protein ID
| CDBP01784 |
| Secondary Accession Numbers
| Not Available |
| Name
| Apolipoprotein A-IV precursor |
| Description
| Not Available |
| Synonyms
|
- Apo-AIV
- ApoA-IV
|
| Gene Name
| APOA4 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Replication, recombination and repair |
| Specific Function
| May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons |
| GO Classification
|
| Component |
| extracellular region |
| Function |
| binding |
| lipid binding |
| Process |
| physiological process |
| metabolism |
| macromolecule metabolism |
| protein metabolism |
| cellular protein metabolism |
| cellular physiological process |
| lipid transport |
| lipoprotein metabolism |
| transport |
|
| Cellular Location
|
- Secreted
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:11 |
| Locus
| 11q23 |
| SNPs
| APOA4 |
| Gene Sequence
|
>1191 bp
ATGTTCCTGAAGGCCGTGGTCCTGACCCTGGCCCTGGTGGCTGTCGCCGGAGCCAGGGCT
GAGGTCAGTGCTGACCAGGTGGCCACAGTGATGTGGGACTACTTCAGCCAGCTGAGCAAC
AATGCCAAGGAGGCCGTGGAACATCTCCAGAAATCTGAACTCACCCAGCAACTCAATGCC
CTCTTCCAGGACAAACTTGGAGAAGTGAACACTTACGCAGGTGACCTGCAGAAGAAGCTG
GTGCCCTTTGCCACCGAGCTGCATGAACGCCTGGCCAAGGACTCGGAGAAACTGAAGGAG
GAGATTGGGAAGGAGCTGGAGGAGCTGAGGGCCCGGCTGCTGCCCCATGCCAATGAGGTG
AGCCAGAAGATCGGGGACAACCTGCGAGAGCTTCAGCAGCGCCTGGAGCCCTACGCGGAC
CAGCTGCGCACCCAGGTCAACACGCAGGCCGAGCAGCTGCGGCGCCAGCTGGACCCCCTA
GCACAGCGCATGGAGAGAGTGCTGCGGGAGAACGCCGACAGCCTGCAGGCCTCGCTGAGG
CCCCACGCCGACGAGCTCAAGGCCAAGATCGACCAGAACGTGGAGGAGCTCAAGGGACGC
CTTACGCCCTACGCTGACGAATTCAAAGTCAAGATTGACCAGACCGTGGAGGAGCTGCGC
CGCAGCCTGGCTCCCTATGCTCAGGACACGCAGGAGAAGCTCAACCACCAGCTTGAGGGC
CTGACCTTCCAGATGAAGAAGAACGCCGAGGAGCTCAAGGCCAGGATCTCGGCCAGTGCC
GAGGAGCTGCGGCAGAGGCTGGCGCCCTTGGCCGAGGACGTGCGTGGCAACCTGAAGGGC
AACACCGAGGGGCTGCAGAAGTCACTGGCAGAGCTGGGTGGGCACCTGGACCAGCAGGTG
GAGGAGTTCCGACGCCGGGTGGAGCCCTACGGGGAAAACTTCAACAAAGCCCTGGTGCAG
CAGATGGAACAGCTCAGGCAGAAACTGGGCCCCCATGCGGGGGACGTGGAAGGCCACTTG
AGCTTCCTGGAGAAGGACCTGAGGGACAAGGTCAACTCCTTCTTCAGCACCTTCAAGGAG
AAAGAGAGCCAGGACAAGACTCTCTCCCTCCCTGAGCTGGAGCAACAGCAGGAACAGCAG
CAGGAGCAGCAGCAGGAGCAGGTGCAGATGCTGGCCCCTTTGGAGAGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 396 |
| Molecular Weight
| 45400.0 |
| Theoretical pI
| 5.05 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Apolipoprotein A-IV precursor
MFLKAVVLTLALVAVAGARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNA
LFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANEV
SQKIGDNLRELQQRLEPYADQLRTQVNTQAEQLRRQLTPYAQRMERVLRENADSLQASLR
PHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEG
LTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQV
EEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKE
KESQDKTLSLPELEQQQEQQQEQQQEQVQMLAPLES
|
| External Links |
|---|
| GenBank ID Protein
| 178759 |
| UniProtKB/Swiss-Prot ID
| P06727 |
| UniProtKB/Swiss-Prot Entry Name
| APOA4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| M13654 |
| GeneCard ID
| APOA4 |
| GenAtlas ID
| APOA4 |
| HGNC ID
| HGNC:602 |
| References |
|---|
| General References
| Not Available |