| Identification |
|---|
| HMDB Protein ID
| CDBP01767 |
| Secondary Accession Numbers
| Not Available |
| Name
| Interferon gamma |
| Description
| Not Available |
| Synonyms
|
- IFN-gamma
- Immune interferon
|
| Gene Name
| IFNG |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in cytokine activity |
| Specific Function
| Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons |
| GO Classification
|
| Component |
| extracellular region |
| Function |
| binding |
| cytokine receptor binding |
| interferon-gamma receptor binding |
| protein binding |
| receptor binding |
| Process |
| immune system process |
| immune response |
|
| Cellular Location
|
- Secreted
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12q14 |
| SNPs
| IFNG |
| Gene Sequence
|
>501 bp
ATGAAATATACAAGTTATATCTTGGCTTTTCAGCTCTGCATCGTTTTGGGTTCTCTTGGC
TGTTACTGCCAGGACCCATATGTAAAAGAAGCAGAAAACCTTAAGAAATATTTTAATGCA
GGTCATTCAGATGTAGCGGATAATGGAACTCTTTTCTTAGGCATTTTGAAGAATTGGAAA
GAGGAGAGTGACAGAAAAATAATGCAGAGCCAAATTGTCTCCTTTTACTTCAAACTTTTT
AAAAACTTTAAAGATGACCAGAGCATCCAAAAGAGTGTGGAGACCATCAAGGAAGACATG
AATGTCAAGTTTTTCAATAGCAACAAAAAGAAACGAGATGACTTCGAAAAGCTGACTAAT
TATTCGGTAACTGACTTGAATGTCCAACGCAAAGCAATACATGAACTCATCCAAGTGATG
GCTGAACTGTCGCCAGCAGCTAAAACAGGGAAGCGAAAAAGGAGTCAGATGCTGTTTCGA
GGTCGAAGAGCATCCCAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 166 |
| Molecular Weight
| 19348.2 |
| Theoretical pI
| 10.01 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Interferon gamma
MKYTSYILAFQLCIVLGSLGCYCQDPYVKEAENLKKYFNAGHSDVADNGTLFLGILKNWK
EESDRKIMQSQIVSFYFKLFKNFKDDQSIQKSVETIKEDMNVKFFNSNKKKRDDFEKLTN
YSVTDLNVQRKAIHELIQVMAELSPAAKTGKRKRSQMLFRGRRASQ
|
| External Links |
|---|
| GenBank ID Protein
| 197692349 |
| UniProtKB/Swiss-Prot ID
| P01579 |
| UniProtKB/Swiss-Prot Entry Name
| IFNG_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AB451324 |
| GeneCard ID
| IFNG |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |