| Identification |
|---|
| HMDB Protein ID
| CDBP01752 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sodium/nucleoside cotransporter 2 |
| Description
| Not Available |
| Synonyms
|
- CNT 2
- Concentrative nucleoside transporter 2
- Na(+)/nucleoside cotransporter 2
- SPNT
- Sodium-coupled nucleoside transporter 2
- Sodium/purine nucleoside co-transporter
- Solute carrier family 28 member 2
- hCNT2
|
| Gene Name
| SLC28A2 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in nucleoside:sodium symporter activity |
| Specific Function
| Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues.
|
| GO Classification
|
| Biological Process |
| nucleobase-containing compound metabolic process |
| Cellular Component |
| integral to plasma membrane |
| Component |
| cell part |
| membrane |
| Function |
| binding |
| nucleoside binding |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity |
| nucleoside transmembrane transporter activity |
| nucleoside:sodium symporter activity |
| transporter activity |
| Molecular Function |
| nucleoside binding |
| nucleoside:sodium symporter activity |
| purine nucleoside transmembrane transporter activity |
| Process |
| establishment of localization |
| transport |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Azathioprine Action Pathway |    | Not Available | | Mercaptopurine Action Pathway |    | Not Available | | Thioguanine Action Pathway |    | Not Available | | Mercaptopurine Metabolism Pathway |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 15 |
| Locus
| 15q15 |
| SNPs
| SLC28A2 |
| Gene Sequence
|
>1977 bp
ATGGAGAAAGCAAGTGGAAGACAGTCCATTGCTCTGTCCACAGTGGAGACTGGCACAGTG
AACCCGGGGCTGGAGCTCATGGAAAAAGAAGTAGAGCCTGAGGGAAGCAAGAGGACTGAC
GCACAAGGACACAGCCTGGGGGATGGACTGGGCCCTTCCACTTACCAGAGGAGGAGTCGG
TGGCCTTTCAGCAAAGCAAGAAGTTTCTGCAAAACACACGCCAGCTTGTTCAAGAAGATC
CTGTTGGGCCTGTTGTGTTTGGCCTATGCTGCCTATCTCCTGGCAGCTTGCATCTTGAAT
TTCCAGAGGGCACTGGCCTTGTTTGTCATCACCTGCTTGGTGATCTTTGTCCTGGTTCAC
TCGTTTTTGAAAAAGCTCCTGGGCAAAAAATTAACAAGATGTCTGAAGCCCTTTGAAAAC
TCCCGCCTGAGGCTTTGGACGAAATGGGTGTTTGCAGGAGTCTCCTTGGTTGGCCTTATA
CTGTGGTTGGCTTTAGACACAGCCCAAAGGCCAGAGCAGCTGATCCCCTTTGCAGGAATC
TGCATGTTCATCCTTATCCTCTTTGCCTGCTCCAAACACCACAGCGCAGTGTCCTGGAGG
ACAGTGTTTTCGGGCCTAGGTCTTCAATTTGTCTTTGGGATCTTGGTCATCAGAACTGAT
CTTGGATATACTGTATTTCAGTGGCTGGGAGAGCAGGTCCAGATTTTCCTGAACTACACT
GTGGCCGGCTCCAGTTTTGTCTTTGGGGATACACTGGTCAAGGATGTCTTTGCTTTTCAG
GCCTTACCAATCATCATTTTCTTTGGATGTGTGGTGTCCATTCTCTACTACCTGGGCCTT
GTGCAATGGGTAGTTCAGAAGGTCGCCTGGTTTTTACAAATCACTATGGGCACCACTGCT
ACAGAGACCCTGGCTGTGGCAGGAAACATCTTTGTGGGTATGACAGAGGCACCTCTGCTC
ATCCGTCCCTACCTTGGGGACATGACACTCTCTGAAATCCATGCGGTGATGACTGGAGGG
TTTGCCACCATTTCTGGCACTGTGCTGGGAGCCTTCATAGCCTTTGGGGTTGATGCATCA
TCCCTGATTTCTGCCTCTGTGATGGCCGCCCCTTGTGCTCTCGCCTCATCAAAGCTAGCG
TATCCGGAAGTGGAGGAGTCCAAGTTCAAGAGTGAGGAGGGGGTAAAGCTGCCCCGTGGG
AAGGAGAGGAATGTCCTGGAAGCTGCCAGCAACGGAGCCGTAGATGCCATAGGCCTTGCT
ACTAATGTAGCAGCCAACCTGATTGCCTTTTTGGCTGTGTTGGCCTTCATCAATGCTGCC
CTCTCCTGGCTGGGGGAATTGGTGGACATACAGGGGCTCACTTTCCAGGTCATCTGCTCC
TATCTCCTAAGGCCCATGGTTTTCATGATGGGTGTAGAATGGACAGACTGTCCAATGGTG
GCTGAGATGGTGGGAATCAAGTTCTTCATAAATGAATTTGTTGCTTATCAGCAACTGTCT
CAATACAAGAACAAACGTCTCTCTGGAATGGAGGAGTGGATTGAGGGAGAGAAACAGTGG
ATTTCTGTGAGAGCTGAAATCATTACAACATTTTCACTCTGTGGATTTGCCAATCTTAGT
TCCATAGGAATCACACTTGGAGGCTTGACATCAATAGTACCTCACCGGAAGAGTGACTTG
TCCAAGGTTGTGGTCAGGGCCCTCTTCACAGGGGCCTGTGTATCCCTTATCAGTGCCTGT
ATGGCAGGAATCCTCTATGTCCCCAGGGGAGCTGAAGCTGACTGTGTCTCCTTCCCAAAC
ACAAGTTTCACCAATAGAACCTATGAGACCTACATGTGCTGCAGAGGGCTCTTTCAGAGT
ACTTCTCTGAATGGCACCAACCCTCCTTCTTTTTCTGGTCCCTGGGAAGATAAGGAGTTC
AGTGCTATGGCCCTTACTAACTGCTGTGGATTCTACAACAATACCGTCTGTGCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 658 |
| Molecular Weight
| 71925.565 |
| Theoretical pI
| 7.949 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Sodium/nucleoside cotransporter 2
MEKASGRQSIALSTVETGTVNPGLELMEKEVEPEGSKRTDAQGHSLGDGLGPSTYQRRSR
WPFSKARSFCKTHASLFKKILLGLLCLAYAAYLLAACILNFQRALALFVITCLVIFVLVH
SFLKKLLGKKLTRCLKPFENSRLRLWTKWVFAGVSLVGLILWLALDTAQRPEQLIPFAGI
CMFILILFACSKHHSAVSWRTVFSGLGLQFVFGILVIRTDLGYTVFQWLGEQVQIFLNYT
VAGSSFVFGDTLVKDVFAFQALPIIIFFGCVVSILYYLGLVQWVVQKVAWFLQITMGTTA
TETLAVAGNIFVGMTEAPLLIRPYLGDMTLSEIHAVMTGGFATISGTVLGAFIAFGVDAS
SLISASVMAAPCALASSKLAYPEVEESKFKSEEGVKLPRGKERNVLEAASNGAVDAIGLA
TNVAANLIAFLAVLAFINAALSWLGELVDIQGLTFQVICSYLLRPMVFMMGVEWTDCPMV
AEMVGIKFFINEFVAYQQLSQYKNKRLSGMEEWIEGEKQWISVRAEIITTFSLCGFANLS
SIGITLGGLTSIVPHRKSDLSKVVVRALFTGACVSLISACMAGILYVPRGAEADCVSFPN
TSFTNRTYETYMCCRGLFQSTSLNGTNPPSFSGPWEDKEFSAMALTNCCGFYNNTVCA
|
| External Links |
|---|
| GenBank ID Protein
| 2665908 |
| UniProtKB/Swiss-Prot ID
| O43868 |
| UniProtKB/Swiss-Prot Entry Name
| S28A2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF036109 |
| GeneCard ID
| SLC28A2 |
| GenAtlas ID
| SLC28A2 |
| HGNC ID
| HGNC:11002 |
| References |
|---|
| General References
| Not Available |