| Identification |
|---|
| HMDB Protein ID
| CDBP01748 |
| Secondary Accession Numbers
| Not Available |
| Name
| Free fatty acid receptor 1 |
| Description
| Not Available |
| Synonyms
|
- G-protein coupled receptor 40
|
| Gene Name
| FFAR1 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor protein signaling pathway |
| Specific Function
| Receptor for medium and long chain saturated and unsaturated fatty acids. Binding of the ligand increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion. The activity of this receptor is mediated by G- proteins that activate phospholipase C. Seems to act through a G(q) and G(i)-mediated pathway |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Process |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| g-protein coupled receptor protein signaling pathway |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19q13.1 |
| SNPs
| FFAR1 |
| Gene Sequence
|
>899 bp
GACCTGCCCCCGCAGCTCTCCTTCGGCCTCTATGTGGCCGCCTTTGCGCTGGGCTTCCCG
CTCAACGCCCTGGCCATCCGAGGCGCGACGGCCCACGCCCGGCTCCGTCTCACCCCTAGC
CTGGTCTACGCCCTGAACCTGGGCTGCTCCGACCTGCTGCTGACAGTCTCTCTGCCCCTG
AAGGCGGTGGAGGCGCTAGCCTCCGGGGCCTGGCCTCTGCCGGCCTCGCTGTGCCCCGTC
TTCGCGGTGGCCCACTTCTTCCCACTCTATGCCGGCGGGGGCTTCCTGGCCGCCCTGAGT
GCAGGCCGCTACCTGGGAGCAGCCTTCCCCTTGGGCTACCAAGCCTTCCGGAGGCCGTGC
TATTCCTGGGGGGTGTGCGCGGCCATCTGGGCCCTCGTCCTGTGTCACCTGGGTCTGGTC
TTTGGGTTGGAGGCTCCAGGAGGCTGGCTGGACCACAGCAACACCTCCCTGGGCATCAAC
ACACCGGTCAACGGCTCTCCGGTCTGCCTGGAGGCCTGGGACCCGGCCTCTGCCGGCCCG
GCCCGCTTCAGCCTCTCTCTCCTGCTCTTTTTTCTGCCCTTGGCCATCACAGCCTTCTGC
TACGTGGGCTGCCTCCGGGCACTGGCCCACTCCGGCCTGACGCACAGGCGGAAGCTGCGG
GCCGCCTGGGTGGCCGGCGGGGCCCTCCTCACGCTGCTGCTCTGCGTAGGACCCTACAAC
GCCTCCAACGTGGCCAGCTTCCTGTACCCCAATCTAGGAGGCTCCTGGCGGAAGCTGGGG
CTCATCACGGGTGCCTGGAGTGTGGTGCTTAATCCGCTGGTGACCGGTTACTTGGGAAGG
GGTCCTGGCCTGAAGACAGTGTGTGCGGCAAGAACGCAAGGGGGCAAGTCCCAGAAGTA
|
| Protein Properties |
|---|
| Number of Residues
| 300 |
| Molecular Weight
| 31456.6 |
| Theoretical pI
| 9.75 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["11-31", "43-63", "82-102", "124-144", "179-197", "222-242", "259-279"]
|
| Protein Sequence
|
>Free fatty acid receptor 1
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLP
LKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRP
CYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAG
PARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPY
NASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
|
| External Links |
|---|
| GenBank ID Protein
| 66267335 |
| UniProtKB/Swiss-Prot ID
| O14842 |
| UniProtKB/Swiss-Prot Entry Name
| FFAR1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC095536 |
| GeneCard ID
| FFAR1 |
| GenAtlas ID
| FFAR1 |
| HGNC ID
| HGNC:4498 |
| References |
|---|
| General References
| Not Available |