| Identification |
|---|
| HMDB Protein ID
| CDBP01745 |
| Secondary Accession Numbers
| Not Available |
| Name
| Methylated-DNA--protein-cysteine methyltransferase |
| Description
| Not Available |
| Synonyms
|
- 6-O-methylguanine-DNA methyltransferase
- MGMT
- O-6-methylguanine-DNA-alkyltransferase
|
| Gene Name
| MGMT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in methylated-DNA-[protein]-cysteine S-methyltransferase activity |
| Specific Function
| Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction:the enzyme is irreversibly inactivated |
| GO Classification
|
| Function |
| methylated-dna-[protein]-cysteine s-methyltransferase activity |
| catalytic activity |
| transferase activity |
| s-methyltransferase activity |
| transferase activity, transferring one-carbon groups |
| methyltransferase activity |
| Process |
| dna repair |
| metabolic process |
| macromolecule metabolic process |
| cellular macromolecule metabolic process |
| dna metabolic process |
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 10q26 |
| SNPs
| MGMT |
| Gene Sequence
|
>624 bp
ATGGACAAGGATTGTGAAATGAAACGCACCACACTGGACAGCCCTTTGGGGAAGCTGGAG
CTGTCTGGTTGTGAGCAGGGTCTGCACGAAATAAAGCTCCTGGGCAAGGGGACGTCTGCA
GCTGATGCCGTGGAGGTCCCAGCCCCCGCTGCGGTTCTCGGAGGTCCGGAGCCCCTGATG
CAGTGCACAGCCTGGCTGAATGCCTATTTCCACCAGCCCGAGGCTATCGAAGAGTTCCCC
GTGCCGGCACTTCACCATCCCGTTTTCCAGCAAGAGTCGTTCACCAGACAGGTGTTATGG
AAGCTGCTGAAGGTTGTGAAATTCGGAGAAGTGATTTCTTACCAGCAATTAGCAGCCCTG
GCAGGCAACCCCAAAGCCGCGCGAGCAGTGGGAGGAGCAATGAGAGGCAATCCTGTCCCC
ATCCTCATCCCGTGCCACAGAGTGGTCTGCAGCAGCGGAGCCGTGGGCAACTACTCCGGA
GGACTGGCCGTGAAGGAATGGCTTCTGGCCCATGAAGGCCACCGGTTGGGGAAGCCAGGC
TTGGGAGGGAGCTCAGGTCTGGCAGGGGCCTGGCTCAAGGGAGCGGGAGCTACCTCGGGC
TCCCCGCCTGCTGGCCGAAACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 207 |
| Molecular Weight
| 21645.8 |
| Theoretical pI
| 8.23 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Methylated-DNA--protein-cysteine methyltransferase
MDKDCEMKRTTLDSPLGKLELSGCEQGLHEIKLLGKGTSAADAVEVPAPAAVLGGPEPLM
QCTAWLNAYFHQPEAIEEFPVPALHHPVFQQESFTRQVLWKLLKVVKFGEVISYQQLAAL
AGNPKAARAVGGAMRGNPVPILIPCHRVVCSSGAVGNYSGGLAVKEWLLAHEGHRLGKPG
LGGSSGLAGAWLKGAGATSGSPPAGRN
|
| External Links |
|---|
| GenBank ID Protein
| 34559 |
| UniProtKB/Swiss-Prot ID
| P16455 |
| UniProtKB/Swiss-Prot Entry Name
| MGMT_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| X54228 |
| GeneCard ID
| MGMT |
| GenAtlas ID
| MGMT |
| HGNC ID
| HGNC:7059 |
| References |
|---|
| General References
| Not Available |