| Identification |
|---|
| HMDB Protein ID
| CDBP01743 |
| Secondary Accession Numbers
| Not Available |
| Name
| Free fatty acid receptor 3 |
| Description
| Not Available |
| Synonyms
|
- G-protein coupled receptor 41
|
| Gene Name
| FFAR3 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor protein signaling pathway |
| Specific Function
| Receptor for short chain fatty acids. The activity of this receptor is coupled to the formation of inositol 1,4,5- trisphosphate, intracellular Ca2+ mobilization, the activation of ERK 1/2 and inhibition of intracellular cAMP accumulation. Coupled exclusively to the pertussis toxin-sensitive G(i/o)-alpha protein. The rank order of potency for agonists of this receptor is propionate = pentanoate = butyrate > acetate > formate |
| GO Classification
|
| Component |
| intrinsic to membrane |
| integral to membrane |
| cell part |
| membrane part |
| Process |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| g-protein coupled receptor protein signaling pathway |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19q13.1 |
| SNPs
| FFAR3 |
| Gene Sequence
|
>1041 bp
ATGGATACAGGCCCCGACCAGTCCTACTTCTCCGGCAATCACTGGTTCGTCTTCTCGGTG
TACCTTCTCACTTTCCTGGTGGGGCTCCCCCTCAACCTGCTGGCCCTGGTGGTCTTCGTG
GGCAAGCTGCAGCGCCGCCCGGTGGCCGTGGACGTGCTCCTGCTCAACCTGACCGCCTCG
GACCTGCTCCTGCTGCTGTTCCTGCCTTTCCGCATGGTGGAGGCAGCCAATGGCATGCAC
TGGCCCCTGCCCTTCATCCTCTGCCCACTCTCTGGATTCATCTTCTTCACCACCATCTAT
CTCACCGCCCTCTTCCTGGCAGCTGTGAGCATTGAACGCTTCCTGAGTGTGGCCCACCCA
CTGTGGTACAAGACCCGGCCGAGGCTGGGGCAGGCAGGTCTGGTGAGTGTGGCCTGCTGG
CTGTTGGCCTCTGCTCACTGCAGCGTGGTCTACGTCATAGAATTCTCAGGGGACATCTCC
CACAGCCAGGGCACCAATGGGACCTGCTACCTGGAGTTCCGGAAGGACCAGCTAGCCATC
CTCCTGCCCGTGCGGCTGGAGATGGCTGTGGTCCTCTTTGTGGTCCCGCTGATCATCACC
AGCTACTGCTACAGCCGCCTGGTGTGGATCCTCGGCAGAGGGGGCAGCCACCGCCGGCAG
AGGAGGGTGGCGGGGCTGTTGGCGGCCACGCTGCTCAACTTCCTTGTCTGCTTTGGGCCC
TACAACGTGTCCCATGTCGTGGGCTATATCTGCGGTGAAAGCCCGGCATGGAGGATCTAC
GTGACGCTTCTCAGCACCCTGAACTCCTGTGTCGACCCCTTTGTCTACTACTTCTCCTCC
TCCGGGTTCCAAGCCGACTTTCATGAGCTGCTGAGGAGGTTGTGTGGGCTCTGGGGCCAG
TGGCAGCAGGAGAGCAGCATGGAGCTGAAGGAGCAGAAGGGAGGGGAGGAGCAGAGAGCG
GACCGACCAGCTGAAAGAAAGACCAGTGAACACTCACAGGGCTGTGGAACTGGTGGCCAG
GTGGCCTGTGCTGAAAGCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 346 |
| Molecular Weight
| 38648.7 |
| Theoretical pI
| 7.88 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["20-40", "48-68", "91-111", "133-153", "179-199", "223-243", "259-279"]
|
| Protein Sequence
|
>Free fatty acid receptor 3
MDTGPDQSYFSGNHWFVFSVYLLTFLVGLPLNLLALVVFVGKLQRRPVAVDVLLLNLTAS
DLLLLLFLPFRMVEAANGMHWPLPFILCPLSGFIFFTTIYLTALFLAAVSIERFLSVAHP
LWYKTRPRLGQAGLVSVACWLLASAHCSVVYVIEFSGDISHSQGTNGTCYLEFRKDQLAI
LLPVRLEMAVVLFVVPLIITSYCYSRLVWILGRGGSHRRQRRVAGLLAATLLNFLVCFGP
YNVSHVVGYICGESPAWRIYVTLLSTLNSCVDPFVYYFSSSGFQADFHELLRRLCGLWGQ
WQQESSMELKEQKGGEEQRADRPAERKTSEHSQGCGTGGQVACAES
|
| External Links |
|---|
| GenBank ID Protein
| 2612948 |
| UniProtKB/Swiss-Prot ID
| O14843 |
| UniProtKB/Swiss-Prot Entry Name
| FFAR3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF024688 |
| GeneCard ID
| FFAR3 |
| GenAtlas ID
| FFAR3 |
| HGNC ID
| HGNC:4499 |
| References |
|---|
| General References
| Not Available |