| Identification |
|---|
| HMDB Protein ID
| CDBP01723 |
| Secondary Accession Numbers
| Not Available |
| Name
| Gastric intrinsic factor |
| Description
| Not Available |
| Synonyms
|
- IF
- INF
- Intrinsic factor
|
| Gene Name
| GIF |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in cobalamin binding |
| Specific Function
| Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum by specific receptor-mediated endocytosis |
| GO Classification
|
| Function |
| binding |
| cobalamin binding |
| vitamin binding |
| Process |
| transport |
| vitamin transport |
| cobalamin transport |
| establishment of localization |
|
| Cellular Location
|
- Secreted
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11q13 |
| SNPs
| GIF |
| Gene Sequence
|
>1254 bp
ATGGCCTGGTTTGCCCTCTACCTCCTGAGCCTTCTCTGGGCTACAGCTGGGACTAGTACC
CAGACCCAGAGTTCATGCTCCGTTCCCTCAGCACAGGAGCCCTTGGTCAATGGAATACAA
GTACTCATGGAGAACTCGGTGACTTCATCAGCCTACCCAAACCCCAGCATCCTGATTGCC
ATGAATCTGGCCGGAGCCTACAACTTGAAGGCCCAGAAGCTCCTGACTTACCAGCTCATG
TCCAGCGACAACAACGATCTAACCATTGGGCAGCTCGGCCTCACCATCATGGCCCTCACC
TCCTCCTGCCGAGACCCTGGGGATAAAGTATCCATTCTACAAAGACAAATGGAGAACTGG
GCACCTTCCAGCCCCAACGCTGAAGCATCAGCCTTCTATGGGCCCAGTCTAGCGATCTTG
GCACTGTGCCAGAAGAACTCTGAGGCGACCTTGCCGATAGCCGTCCGCTTTGCCAAGACC
CTGCTGGCCAACTCCTCTCCCTTCAATGTAGACACAGGAGCAATGGCAACCTTGGCTCTG
ACCTGTATGTACAACAAGATCCCTGTAGGTTCAGAGGAAGGTTACAGATCCCTGTTTGGT
CAGGTACTAAAGGATATTGTGGAGAAAATCAGCATGAAGATCAAAGATAATGGCATCATT
GGAGACATCTACAGTACTGGCCTCGCCATGCAGGCTCTCTCTGTAACACCTGAGCCATCT
AAAAAGGAATGGAACTGCAAGAAGACTACGGATATGATACTCAATGAGATTAAGCAGGGG
AAATTCCACAACCCCATGTCCATTGCTCAAATCCTCCCTTCCCTGAAAGGCAAGACATAC
CTAGATGTGCCCCAGGTCACTTGTAGTCCTGATCATGAGGTACAACCAACTCTACCCAGC
AACCCTGGCCCTGGCCCCACCTCTGCATCTAACATCACTGTCATATACACCATAAATAAC
CAGCTGAGGGGGGTTGAGCTGCTCTTCAACGAGACCATCAATGTTAGTGTGAAAAGTGGG
TCAGTGTTACTTGTTGTCCTAGAGGAAGCACAGCGCAAAAATCCTATGTTCAAATTTGAA
ACCACAATGACATCTTGGGGCCTTGTCGTCTCTTCTATCAACAATATCGCGGAAAATGTT
AATCACAAGACATACTGGCAGTTTCTTAGTGGTGTAACACCTTTGAATGAAGGGGTTGCT
GACTACATACCCTTCAACCACGAGCACATCACAGCCAATTTCACACAGTACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 417 |
| Molecular Weight
| 45415.7 |
| Theoretical pI
| 6.04 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Gastric intrinsic factor
MAWFALYLLSLLWATAGTSTQTQSSCSVPSAQEPLVNGIQVLMENSVTSSAYPNPSILIA
MNLAGAYNLKAQKLLTYQLMSSDNNDLTIGQLGLTIMALTSSCRDPGDKVSILQRQMENW
APSSPNAEASAFYGPSLAILALCQKNSEATLPIAVRFAKTLLANSSPFNVDTGAMATLAL
TCMYNKIPVGSEEGYRSLFGQVLKDIVEKISMKIKDNGIIGDIYSTGLAMQALSVTPEPS
KKEWNCKKTTDMILNEIKQGKFHNPMSIAQILPSLKGKTYLDVPQVTCSPDHEVQPTLPS
NPGPGPTSASNITVIYTINNQLRGVELLFNETINVSVKSGSVLLVVLEEAQRKNPMFKFE
TTMTSWGLVVSSINNIAENVNHKTYWQFLSGVTPLNEGVADYIPFNHEHITANFTQY
|
| External Links |
|---|
| GenBank ID Protein
| 23958689 |
| UniProtKB/Swiss-Prot ID
| P27352 |
| UniProtKB/Swiss-Prot Entry Name
| IF_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC037958 |
| GeneCard ID
| GIF |
| GenAtlas ID
| GIF |
| HGNC ID
| HGNC:4268 |
| References |
|---|
| General References
| Not Available |