| Identification |
|---|
| HMDB Protein ID
| CDBP01713 |
| Secondary Accession Numbers
| Not Available |
| Name
| P-selectin glycoprotein ligand 1 |
| Description
| Not Available |
| Synonyms
|
- CD162 antigen
- PSGL-1
- Selectin P ligand
|
| Gene Name
| SELPLG |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Replication, recombination and repair |
| Specific Function
| A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. PSGL1 is critical for the initial leukocyte capture |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Membrane
- Single-pass type I membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12q24 |
| SNPs
| SELPLG |
| Gene Sequence
|
>1239 bp
ATGCCTCTGCAACTCCTCCTGTTGCTGATCCTACTGGGCCCTGGCAACAGCTTGCAGCTG
TGGGACACCTGGGCAGATGAAGCCGAGAAAGCCTTGGGTCCCCTGCTTGCCCGGGACCGG
AGACAGGCCACCGAATATGAGTACCTAGATTATGATTTCCTGCCAGAAACGGAGCCTCCG
GAAATACTGAGGAACAGCACTGACACCACTCCTCTGACTGGGCCTGGAACCCCTGAGTCT
ACCACTGTGGAGCCTGCTGCAAGGCGTTCTACTGGCCTGGATGCAGGAGGGGCAGTCACA
GAGCTGACCACGGAGCTGGCCAACATGGGGAACCTGTCCACGGATTCAGCAGCTATGGAG
ATACAGACCACTCAACCAGCAGCCACGGAGGCACAGACCACTCAACCAGTGCCCACGGAG
GCACAGACCACTCCACTGGCAGCCACAGAGGCACAGACAACTCGACTGACGGCCACGGAG
GCACAGACCACTCCACTGGCAGCCACAGAGGCACAGACCACTCCACCAGCAGCCACGGAA
GCACAGACCACTCAACCCACAGGCCTGGAGGCACAGACCACTGCACCAGCAGCCATGGAG
GCACAGACCACTGCACCAGCAGCCATGGAAGCACAGACCACTCCACCAGCAGCCATGGAG
GCACAGACCACTCAAACCACAGCCATGGAGGCACAGACCACTGCACCAGAAGCCACGGAG
GCACAGACCACTCAACCCACAGCCACGGAGGCACAGACCACTCCACTGGCAGCCATGGAG
GCCCTGTCCACAGAACCCAGTGCCACAGAGGCCCTGTCCATGGAACCTACTACCAAAAGA
GGTCTGTTCATACCCTTTTCTGTGTCCTCTGTTACTCACAAGGGCATTCCCATGGCAGCC
AGCAATTTGTCCGTCAACTACCCAGTGGGGGCCCCAGACCACATCTCTGTGAAGCAGTGC
CTGCTGGCCATCCTAATCTTGGCGCTGGTGGCCACTATCTTCTTCGTGTGCACTGTGGTG
CTGGCGGTCCGCCTCTCCCGCAAGGGCCACATGTACCCCGTGCGTAATTACTCCCCCACC
GAGATGGTCTGCATCTCATCCCTGTTGCCTGATGGGGGTGAGGGGCCCTCTGCCACAGCC
AATGGGGGCCTGTCCAAGGCCAAGAGCCCGGGCCTGACGCCAGAGCCCAGGGAGGACCGT
GAGGGGGATGACCTCACCCTGCACAGCTTCCTCCCTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 412 |
| Molecular Weight
| 43201.0 |
| Theoretical pI
| 4.06 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>P-selectin glycoprotein ligand 1
MPLQLLLLLILLGPGNSLQLWDTWADEAEKALGPLLARDRRQATEYEYLDYDFLPETEPP
EMLRNSTDTTPLTGPGTPESTTVEPAARRSTGLDAGGAVTELTTELANMGNLSTDSAAME
IQTTQPAATEAQTTQPVPTEAQTTPLAATEAQTTRLTATEAQTTPLAATEAQTTPPAATE
AQTTQPTGLEAQTTAPAAMEAQTTAPAAMEAQTTPPAAMEAQTTQTTAMEAQTTAPEATE
AQTTQPTATEAQTTPLAAMEALSTEPSATEALSMEPTTKRGLFIPFSVSSVTHKGIPMAA
SNLSVNYPVGAPDHISVKQCLLAILILALVATIFFVCTVVLAVRLSRKGHMYPVRNYSPT
EMVCISSLLPDGGEGPSATANGGLSKAKSPGLTPEPREDREGDDLTLHSFLP
|
| External Links |
|---|
| GenBank ID Protein
| 194385012 |
| UniProtKB/Swiss-Prot ID
| Q14242 |
| UniProtKB/Swiss-Prot Entry Name
| SELPL_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK298738 |
| GeneCard ID
| SELPLG |
| GenAtlas ID
| SELPLG |
| HGNC ID
| HGNC:10722 |
| References |
|---|
| General References
| Not Available |