| Identification |
|---|
| HMDB Protein ID
| CDBP01689 |
| Secondary Accession Numbers
| Not Available |
| Name
| Histone H2A type 1-C |
| Description
| Not Available |
| Synonyms
|
- Histone H2A/l
|
| Gene Name
| HIST1H2AC |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in DNA binding |
| Specific Function
| Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling |
| GO Classification
|
| Component |
| macromolecular complex |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| nucleus |
| nucleosome |
| protein-dna complex |
| Function |
| binding |
| nucleic acid binding |
| dna binding |
| Process |
| cellular process |
| cellular component organization at cellular level |
| organelle organization |
| chromosome organization |
| chromatin organization |
| nucleosome assembly |
| nucleosome organization |
|
| Cellular Location
|
- Nucleus
- Chromosome
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:6 |
| Locus
| 6p21.3 |
| SNPs
| HIST1H2AC |
| Gene Sequence
|
>393 bp
ATGTCTGGACGTGGTAAGCAAGGAGGCAAAGCTCGCGCCAAAGCGAAATCCCGCTCTTCT
CGCGCTGGTCTCCAGTTCCCGGTGGGCCGAGTGCACCGCCTGCTCCGTAAAGGCAACTAC
GCAGAGCGGGTTGGGGCAGGCGCGCCGGTGTACCTGGCGGCGGTGTTAGAGTACCTGACC
GCCGAGATCCTGGAGCTGGCCGGCAACGCGGCTCGCGACAACAAGAAGACTCGCATCATC
CCGCGCCACTTGCAGCTGGCCATCCGCAACGACGAGGAGCTCAACAAACTGCTAGGCCGG
GTGACCATTGCTCAGGGCGGCGTCCTTCCTAACATCCAGGCCGTGCTTCTGCCTAAGAAG
ACCGAGAGTCACCACAAGGCCAAGGGCAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 130 |
| Molecular Weight
| 14105.4 |
| Theoretical pI
| 11.66 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Histone H2A type 1-C
MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLT
AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPKK
TESHHKAKGK
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q93077 |
| UniProtKB/Swiss-Prot Entry Name
| H2A1C_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| U90551 |
| GeneCard ID
| HIST1H2AC |
| GenAtlas ID
| HIST1H2AC |
| HGNC ID
| HGNC:4733 |
| References |
|---|
| General References
| Not Available |