Cannabis Compound Database: Showing Protein Delta(24)-sterol reductase (CDBP01688)

Identification Biological properties Gene properties Protein properties External links References XML Show 19 compounds

Identification

HMDB Protein ID

CDBP01688

Secondary Accession Numbers

Not Available

Name

Delta(24)-sterol reductase

Description

Not Available

Synonyms

3-beta-hydroxysterol delta-24-reductase
Diminuto/dwarf1 homolog
Seladin-1
24-dehydrocholesterol reductase

Gene Name

DHCR24

Protein Type

Enzyme

Biological Properties

General Function

Energy production and conversion

Specific Function

Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis.

GO Classification

Biological Process
plasminogen activation
Ras protein signal transduction
regulation of neuron death
negative regulation of cell proliferation
skin development
cellular membrane organization
cell cycle arrest
negative regulation of apoptotic process
response to oxidative stress
cholesterol biosynthetic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
protein localization
male genitalia development
amyloid precursor protein catabolic process
Cellular Component
endoplasmic reticulum membrane
cytosol
cytoskeleton
nucleus
integral to membrane
Golgi membrane
Function
adenyl nucleotide binding
oxidoreductase activity
fad or fadh2 binding
binding
catalytic activity
nucleoside binding
purine nucleoside binding
Molecular Function
UDP-N-acetylmuramate dehydrogenase activity
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
delta24-sterol reductase activity
peptide antigen binding
flavin adenine dinucleotide binding

Cellular Location

Golgi apparatus membrane
Endoplasmic reticulum membrane
Single-pass membrane protein
Single-pass membrane protein

Pathways

Name	SMPDB/Pathwhiz	KEGG
cholesterol biosynthesis	Not Available	Not Available
Steroid Biosynthesis
Smith-Lemli-Opitz Syndrome (SLOS)		Not Available
CHILD Syndrome		Not Available
Desmosterolosis		Not Available

Gene Properties

Chromosome Location

Locus

1p32.3

SNPs

DHCR24

Gene Sequence

>1551 bp
ATGGAGCCCGCCGTGTCGCTGGCCGTGTGCGCGCTGCTCTTCCTGCTGTGGGTGCGCCTG
AAGGGGCTGGAGTTCGTGCTCATCCACCAGCGCTGGGTGTTCGTGTGCCTCTTCCTCCTG
CCGCTCTCGCTTATCTTCGATATCTACTACTACGTGCGCGCCTGGGTGGTGTTCAAGCTC
AGCAGCGCTCCGCGCCTGCACGAGCAGCGCGTGCGGGACATCCAGAAGCAGGTGCGGGAA
TGGAAGGAGCAGGGTAGCAAGACCTTCATGTGCACGGGGCGCCCTGGCTGGCTCACTGTC
TCACTACGTGTCGGGAAGTACAAGAAGACACACAAAAACATCATGATCAACCTGATGGAC
ATTCTGGAAGTGGACACCAAGAAACAGATTGTCCGTGTGGAGCCCTTGGTGACCATGGGC
CAGGTGACTGCCCTGCTGACCTCCATTGGCTGGACTCTCCCCGTGTTGCCTGAGCTTGAT
GACCTCACAGTGGGGGGCTTGATCATGGGCACAGGCATCGAGTCATCATCCCACAAGTAC
GGCCTGTTCCAACACATCTGCACTGCTTACGAGCTGGTCCTGGCTGATGGCAGCTTTGTG
CGATGCACTCCGTCCGAAAACTCAGACCTGTTCTATGCCGTACCCTGGTCCTGTGGGACG
CTGGGTTTCCTGGTGGCCGCTGAGATCCGCATCATCCCTGCCAAGAAGTACGTCAAGCTG
CGTTTCGAGCCAGTGCGGGGCCTGGAGGCTATCTGTGCCAAGTTCACCCACGAGTCCCAG
CGGCAGGAGAACCACTTCGTGGAAGGGCTGCTCTACTCCCTGGATGAGGCTGTCATTATG
ACAGGGGTCATGACAGATGAGGCAGAGCCCAGCAAGCTGAATAGCATTGGCAATTACTAC
AAGCCGTGGTTCTTTAAGCATGTGGAGAACTATCTGAAGACAAACCGAGAGGGCCTGGAG
TACATTCCCTTGAGACACTACTACCACCGCCACACGCGCAGCATCTTCTGGGAGCTCCAG
GACATCATCCCCTTTGGCAACAACCCCATCTTCCGCTACCTCTTTGGCTGGATGGTGCCT
CCCAAGATCTCCCTCCTGAAGCTGACCCAGGGTGAGACCCTGCGCAAGCTGTACGAGCAG
CACCACGTGGTGCAGGACATGCTGGTGCCCATGAAGTGCCTGCAGCAGGCCCTGCACACC
TTCCAAAACGACATCCACGTCTACCCCATCTGGCTGTGTCCGTTCATCCTGCCCAGCCAG
CCAGGCCTAGTGCACCCCAAAGGAAATGAGGCAGAGCTCTACATCGACATTGGAGCATAT
GGGGAGCCGCGTGTGAAACACTTTGAAGCCAGGTCCTGCATGAGGCAGCTGGAGAAGTTT
GTCCGCAGCGTGCATGGCTTCCAGATGCTGTATGCCGACTGCTACATGAACCGGGAGGAG
TTCTGGGAGATGTTTGATGGCTCCTTGTACCACAAGCTGCGAGAGAAGCTGGGTTGCCAG
GACGCCTTCCCCGAGGTGTACGACAAGATCTGCAAGGCCGCCAGGCACTGA

Protein Properties

Number of Residues

516

Molecular Weight

60100.805

Theoretical pI

8.158

Pfam Domain Function

FAD_binding_4 (PF01565 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>24-dehydrocholesterol reductase
MEPAVSLAVCALLFLLWVRLKGLEFVLIHQRWVFVCLFLLPLSLIFDIYYYVRAWVVFKL
SSAPRLHEQRVRDIQKQVREWKEQGSKTFMCTGRPGWLTVSLRVGKYKKTHKNIMINLMD
ILEVDTKKQIVRVEPLVTMGQVTALLTSIGWTLPVLPELDDLTVGGLIMGTGIESSSHKY
GLFQHICTAYELVLADGSFVRCTPSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVKL
RFEPVRGLEAICAKFTHESQRQENHFVEGLLYSLDEAVIMTGVMTDEAEPSKLNSIGNYY
KPWFFKHVENYLKTNREGLEYIPLRHYYHRHTRSIFWELQDIIPFGNNPIFRYLFGWMVP
PKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCLQQALHTFQNDIHVYPIWLCPFILPSQ
PGLVHPKGNEAELYIDIGAYGEPRVKHFEARSCMRQLEKFVRSVHGFQMLYADCYMNREE
FWEMFDGSLYHKLREKLGCQDAFPEVYDKICKAARH

External Links

GenBank ID Protein

10442025

UniProtKB/Swiss-Prot ID

Q15392

UniProtKB/Swiss-Prot Entry Name

DHC24_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF261758

GeneCard ID