| Identification |
|---|
| HMDB Protein ID
| CDBP01683 |
| Secondary Accession Numbers
| Not Available |
| Name
| Class E basic helix-loop-helix protein 40 |
| Description
| Not Available |
| Synonyms
|
- Class B basic helix-loop-helix protein 2
- DEC1
- Differentially expressed in chondrocytes protein 1
- Enhancer-of-split and hairy-related protein 2
- SHARP-2
- Stimulated by retinoic acid gene 13 protein
- bHLHb2
- bHLHe40
|
| Gene Name
| BHLHE40 |
| Protein Type
| Transcription Factor |
| Biological Properties |
|---|
| General Function
| Involved in transcription regulator activity |
| Specific Function
| May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway |
| GO Classification
|
| Component |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| nucleus |
| Function |
| binding |
| transcription regulator activity |
| nucleic acid binding |
| dna binding |
| Process |
| regulation of gene expression |
| regulation of transcription |
| regulation of transcription, dna-dependent |
| biological regulation |
| regulation of biological process |
| regulation of metabolic process |
| regulation of macromolecule metabolic process |
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3p26 |
| SNPs
| BHLHE40 |
| Gene Sequence
|
>1239 bp
ATGGAGCGGATCCCCAGCGCGCAACCACCCCCCGCCTGCCTGCCCAAAGCACCGGGACTG
GAGCACGGAGACCTACCAGGGATGTACCCTGCCCACATGTACCAAGTGTACAAGTCAAGA
CGGGGAATAAAGCGGAGCGAGGACAGCAAGGAGACCTACAAATTGCCGCACCGGCTCATC
GAGAAAAAGAGACGTGACCGGATTAACGAGTGCATCGCCCAGCTGAAGGATCTCCTACCC
GAACATCTCAAACTTACAACTTTGGGTCACTTGGAAAAAGCAGTGGTTCTTGAACTTACC
TTGAAGCATGTGAAAGCACTAACAAACCTAATTGATCAGCAGCAGCAGAAAATCATTGCC
CTGCAGAGTGGTTTACAAGCTGGTGAGCTGTCAGGGAGAAATGTCGAAACAGGTCAAGAG
ATGTTCTGCTCAGGTTTCCAGACATGTGCCCGGGAGGTGCTTCAGTATCTGGCCAAGCAC
GAGAACACTCGGGACCTGAAGTCTTCGCAGCTTGTCACCCACCTCCACCGGGTGGTCTCG
GAGCTGCTGCAGGGTGGTACCTCCAGGAAGCCATCAGACCCAGCTCCCAAAGTGATGGAC
TTCAAGGAAAAACCCAGCTCTCCGGCCAAAGGTTCGGAAGGTCCTGGGAAAAACTGCGTG
CCAGTCATCCAGCGGACTTTCGCTCACTCGAGTGGGGAGCAGAGCGGCAGCGACACGGAC
ACAGACAGTGGCTATGGAGGAGAATCGGAGAAGGGCGACTTGCGCAGTGAGCAGCCGTGC
TTCAAAAGTGACCACGGACGCAGGTTCACGATGGGAGAAAGGATCGGCGCAATTAAGCAA
GAGTCCGAAGAACCCCCCACAAAAAAGAACCGGATGCAGCTTTCGGATGATGAAGGCCAT
TTCACTAGCAGTGACCTGATCAGCTCCCCGTTCCTGGGCCCACACCCACACCAGCCTCCT
TTCTGCCTGCCCTTCTACCTGATCCCACCTTCAGCGACTGCCTACCTGCCCATGCTGGAG
AAGTGCTGGTATCCCACCTCAGTGCCAGTGCTATACCCAGGCCTCAACGCCTCTGCCGCA
GCCCTCTCTAGCTTCATGAACCCAGACAAGATCTCGGCTCCCTTGCTCATGCCCCAGAGA
CTCCCTTCTCCCTTGCCAGCTCATCCGTCCGTCGACTCTTCTGTCTTGCTCCAAGCTCTG
AAGCCAATCCCCCCTTTAAACTTAGAAACCAAAGACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 412 |
| Molecular Weight
| 45509.6 |
| Theoretical pI
| 8.22 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Class E basic helix-loop-helix protein 40
MERIPSAQPPPACLPKAPGLEHGDLPGMYPAHMYQVYKSRRGIKRSEDSKETYKLPHRLI
EKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVKALTNLIDQQQQKIIA
LQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHENTRDLKSSQLVTHLHRVVS
ELLQGGTSRKPSDPAPKVMDFKEKPSSPAKGSEGPGKNCVPVIQRTFAHSSGEQSGSDTD
TDSGYGGESEKGDLRSEQPCFKSDHGRRFTMGERIGAIKQESEEPPTKKNRMQLSDDEGH
FTSSDLISSPFLGPHPHQPPFCLPFYLIPPSATAYLPMLEKCWYPTSVPVLYPGLNASAA
ALSSFMNPDKISAPLLMPQRLPSPLPAHPSVDSSVLLQALKPIPPLNLETKD
|
| External Links |
|---|
| GenBank ID Protein
| 2308997 |
| UniProtKB/Swiss-Prot ID
| O14503 |
| UniProtKB/Swiss-Prot Entry Name
| BHE40_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB004066 |
| GeneCard ID
| BHLHE40 |
| GenAtlas ID
| BHLHE40 |
| HGNC ID
| HGNC:1046 |
| References |
|---|
| General References
| Not Available |