| Identification |
|---|
| HMDB Protein ID
| CDBP01664 |
| Secondary Accession Numbers
| Not Available |
| Name
| Glucose-6-phosphate translocase |
| Description
| Not Available |
| Synonyms
|
- Glucose-5-phosphate transporter
- Solute carrier family 37 member 4
- TRG-19
- Transformation-related gene 19 protein
|
| Gene Name
| SLC37A4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Carbohydrate transport and metabolism |
| Specific Function
| Transports glucose-6-phosphate from the cytoplasm to the lumen of the endoplasmic reticulum. Forms with glucose-6- phosphatase the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| transporter activity |
| Process |
| establishment of localization |
| transport |
| transmembrane transport |
|
| Cellular Location
|
- Multi-pass membrane protein (Potential)
- Endoplasmic reticulum membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Gluconeogenesis |    |  | | Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease |    | Not Available | | Phosphoenolpyruvate carboxykinase deficiency 1 (PEPCK1) |    | Not Available | | Fructose-1,6-diphosphatase deficiency |    | Not Available | | Triosephosphate isomerase |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11q23.3 |
| SNPs
| SLC37A4 |
| Gene Sequence
|
>1290 bp
ATGGCAGCCCAGGGCTATGGCTATTATCGCACTGTGATCTTCTCAGCCATGTTTGGGGGC
TACAGCCTGTATTACTTCAATCGCAAGACCTTCTCCTTTGTCATGCCATCATTGGTGGAA
GAGATCCCTTTGGACAAGGATGATTTGGGGTTCATCACCAGCAGCCAGTCGGCAGCTTAT
GCTATCAGCAAGTTTGTCAGTGGGGTGCTGTCTGACCAGATGAGTGCTCGCTGGCTCTTC
TCTTCTGGGCTGCTCCTGGTTGGCCTGGTCAACATATTCTTTGCCTGGAGCTCCACAGTA
CCTGTCTTTGCTGCCCTCTGGTTCCTTAATGGCCTGGCCCAGGGGCTGGGCTGGCCCCCA
TGTGGGAAGGTCCTGCGGAAGTGGTTTGAGCCATCTCAGTTTGGCACTTGGTGGGCCATC
CTGTCAACCAGCATGAACCTGGCTGGAGGGCTGGGCCCTATCCTGGCAACCATCCTTGCC
CAGAGCTACAGCTGGCGCAGCACGCTGGCCCTATCTGGGGCACTGTGTGTGGTTGTCTCC
TTCCTCTGTCTCCTGCTCATCCACAATGAACCTGCTGATGTTGGACTCCGCAACCTGGAC
CCCATGCCCTCTGAGGGCAAGAAGGGCTCCTTGAAGGAGGAGAGCACCCTGCAGGAGCTG
CTGCTGTCCCCTTACCTGTGGGTGCTCTCCACTGGTTACCTTGTGGTGTTTGGAGTAAAG
ACCTGCTGTACTGACTGGGGCCAGTTCTTCCTTATCCAGGAGAAAGGACAGTCAGCCCTT
GTAGGTAGCTCCTACATGAGTGCCCTGGAAGTTGGGGGCCTTGTAGGCAGCATCGCAGCT
GGCTACCTGTCAGACCGGGCCATGGCAAAGGCGGGACTGTCCAACTACGGGAACCCTCGC
CATGGCCTGTTGCTGTTCATGATGGCTGGCATGACAGTGTCCATGTACCTCTTCCGGGTA
ACAGTGACCAGTGACTCCCCCAAGCTCTGGATCCTGGTATTGGGAGCTGTATTTGGTTTC
TCCTCGTATGGCCCCATTGCCCTGTTTGGAGTCATAGCCAACGAGAGTGCCCCTCCCAAC
TTGTGTGGCACCTCCCACGCCATTGTGGGACTCATGGCCAATGTGGGCGGCTTTCTGGCT
GGGCTGCCCTTCAGCACCATTGCCAAGCACTACAGTTGGAGCACAGCCTTCTGGGTGGCT
GAAGTGATTTGTGCGGCCAGCACGGCTGCCTTCTTCCTCCTACGAAACATCCGCACCAAG
ATGGGCCGAGTGTCCAAGAAGGCTGAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 429 |
| Molecular Weight
| 46359.6 |
| Theoretical pI
| 8.77 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["84-104", "105-125", "139-159", "167-187", "219-239", "260-280", "302-322", "329-349", "368-388", "394-414"]
|
| Protein Sequence
|
>Glucose-6-phosphate translocase
MAAQGYGYYRTVIFSAMFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAY
AISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPP
CGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALCVVVS
FLCLLLIHNEPADVGLRNLDPMPSEGKKGSLKEESTLQELLLSPYLWVLSTGYLVVFGVK
TCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKAGLSNYGNPR
HGLLLFMMAGMTVSMYLFRVTVTSDSPKLWILVLGAVFGFSSYGPIALFGVIANESAPPN
LCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFFLLRNIRTK
MGRVSKKAE
|
| External Links |
|---|
| GenBank ID Protein
| 3859932 |
| UniProtKB/Swiss-Prot ID
| O43826 |
| UniProtKB/Swiss-Prot Entry Name
| G6PT1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF078163 |
| GeneCard ID
| SLC37A4 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |