| Identification |
|---|
| HMDB Protein ID
| CDBP01663 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protein S100-A8 |
| Description
| Not Available |
| Synonyms
|
- CFAG
- Calgranulin-A
- Calprotectin L1L subunit
- Cystic fibrosis antigen
- Leukocyte L1 complex light chain
- MRP-8
- Migration inhibitory factor-related protein 8
- S100 calcium-binding protein A8
- Urinary stone protein band A
- p8
|
| Gene Name
| S100A8 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Calcium-binding protein. Has antimicrobial activity towards bacteria and fungi. Important for resistance to invasion by pathogenic bacteria. Up-regulates transcription of genes that are under the control of NF-kappa-B. Plays a role in the development of endotoxic shock in response to bacterial lipopolysaccharide (LPS). Promotes tubulin polymerization. Promotes phagocyte migration and infiltration of granulocytes at sites of wounding. Plays a role as pro- inflammatory mediator in acute and chronic inflammation and up- regulates the release of IL8 and cell-surface expression of ICAM1. Extracellular calprotectin binds to target cells and promotes apoptosis. Antimicrobial and proapoptotic activity is inhibited by zinc ions |
| GO Classification
|
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
|
| Cellular Location
|
- Cell membrane
- Cytoplasm
- Cytoplasm
- Peripheral membrane protein
- Secreted
- cytoskeleton
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q21 |
| SNPs
| S100A8 |
| Gene Sequence
|
>282 bp
ATGTTGACCGAGCTGGAGAAAGCCTTGAACTCTATCATCGACGTCTACCACAAGTACTCC
CTGATAAAGGGGAATTTCCATGCCGTCTACAGGGATGACCTGAAGAAATTGCTAGAGACC
GAGTGTCCTCAGTATATCAGGAAAAAGGGTGCAGACGTCTGGTTCAAAGAGTTGGATATC
AACACTGATGGTGCAGTTAACTTCCAGGAGTTCCTCATTCTGGTGATAAAGATGGGCGTG
GCAGCCCACAAAAAAAGCCATGAAGAAAGCCACAAAGAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 93 |
| Molecular Weight
| 10834.4 |
| Theoretical pI
| 7.07 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Protein S100-A8
MLTELEKALNSIIDVYHKYSLIKGNFHAVYRDDLKKLLETECPQYIRKKGADVWFKELDI
NTDGAVNFQEFLILVIKMGVAAHKKSHEESHKE
|
| External Links |
|---|
| GenBank ID Protein
| 158256092 |
| UniProtKB/Swiss-Prot ID
| P05109 |
| UniProtKB/Swiss-Prot Entry Name
| S10A8_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AK291328 |
| GeneCard ID
| S100A8 |
| GenAtlas ID
| S100A8 |
| HGNC ID
| HGNC:10498 |
| References |
|---|
| General References
| Not Available |