| Identification |
|---|
| HMDB Protein ID
| CDBP01632 |
| Secondary Accession Numbers
| Not Available |
| Name
| Dehydrogenase/reductase SDR family member 2 |
| Description
| Not Available |
| Synonyms
|
- Dicarbonyl reductase HEP27
- Protein D
|
| Gene Name
| DHRS2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2- propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. May inhibit cell replication |
| GO Classification
|
| Function |
| binding |
| catalytic activity |
| oxidoreductase activity |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 14q11.2 |
| SNPs
| DHRS2 |
| Gene Sequence
|
>843 bp
ATGCTGTCAGCAGTTGCCCGGGGCTACCAGGGCTGGTTTCATCCCTGTGCTAGGCTTTCT
GTGAGGATGAGCAGCACCGGGATAGACAGGAAGGGCGTCCTGGCTAACCGGGTAGCCGTG
GTCACGGGGTCCACCAGTGGGATCGGCTTTGCCATCGCCCGACGTCTGGCCCGGGACGGG
GCCCACGTGGTCATCAGCAGCCGGAAGCAGCAGAACGTGGACCGGGCCATGGCCAAGCTG
CAGGGGGAGGGGCTGAGTGTGGCGGGCATTGTGTGCCACGTGGGGAAGGCTGAGGACCGG
GAGCAGCTGGTGGCCAAGGCCCTGGAGCACTGTGGGGGCGTCGACTTCCTGGTGTGCAGC
GCAGGGGTCAACCCTCTGGTAGGGAGCACTCTGGGGACCAGTGAGCAGATCTGGGACAAG
ATCCTAAGTGTGAACGTGAAGTCCCCAGCCCTGCTGCTGAGCCAGTTGCTGCCCTACATG
GAGAACAGGAGGGGTGCTGTCATCCTGGTCTCTTCCATTGCAGCTTATAATCCAGTAGTG
GCGCTGGGTGTCTACAATGTCAGCAAGACAGCGCTGCTGGGTCTCACTAGAACACTGGCA
TTGGAGCTGGCCCCCAAGGACATCCGGGTAAACTGCGTGGTTCCAGGAATTATCAAAACT
GACTTCAGCAAAGTGTTTCATGGGAATGAGTCTCTCTGGAAGAACTTCAAGGAACATCAT
CAGCTGCAGAGGATTGGGGAGTCAGAGGACTGTGCAGGAATCGTGTCCTTCCTGTGCTCT
CCAGATGCCAGCTACGTCAACGGGGAGAACATTGCGGTGGCAGGCTACTCCACTCGGCTC
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 258 |
| Molecular Weight
| 27438.4 |
| Theoretical pI
| 8.81 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Dehydrogenase/reductase SDR family member 2
MSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQG
EGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKIL
SVNVKSPALLLSQLLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALE
LAPKDIRVNCVVPGIIKTDFSKVFHGNESLWKNFKEHHQLQRIGESEDCAGIVSFLCSPD
ASYVNGENIAVAGYSTRL
|
| External Links |
|---|
| GenBank ID Protein
| 5031737 |
| UniProtKB/Swiss-Prot ID
| Q13268 |
| UniProtKB/Swiss-Prot Entry Name
| DHRS2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_005794 |
| GeneCard ID
| DHRS2 |
| GenAtlas ID
| DHRS2 |
| HGNC ID
| HGNC:18349 |
| References |
|---|
| General References
| Not Available |