Showing Protein Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (CDBP01631)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 3 compounds
Identification
HMDB Protein ID CDBP01631
Secondary Accession Numbers Not Available
Name Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Description Not Available
Synonyms
  1. CAAX farnesyltransferase subunit alpha
  2. FTase-alpha
  3. GGTase-I-alpha
  4. Ras proteins prenyltransferase subunit alpha
  5. Type I protein geranyl-geranyltransferase subunit alpha
Gene Name FNTA
Protein Type Enzyme
Biological Properties
General Function Involved in protein prenyltransferase activity
Specific Function Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity).
GO Classification
Biological Process
positive regulation of deacetylase activity
positive regulation of tubulin deacetylation
protein farnesylation
protein geranylgeranylation
cellular component disassembly involved in execution phase of apoptosis
transforming growth factor beta receptor signaling pathway
Cellular Component
cytosol
microtubule associated complex
Function
catalytic activity
transferase activity
protein prenyltransferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
prenyltransferase activity
Molecular Function
alpha-tubulin binding
microtubule binding
CAAX-protein geranylgeranyltransferase activity
protein farnesyltransferase activity
protein geranylgeranyltransferase activity
Process
metabolic process
macromolecule metabolic process
protein amino acid lipidation
protein prenylation
protein amino acid prenylation
macromolecule modification
protein modification process
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location 8
Locus 8p11
SNPs FNTA
Gene Sequence 
>1140 bp
ATGGCGGCCACCGAGGGGGTCGGGGAGGCTGCGCAAGGGGGCGAGCCCGGGCAGCCGGCG
CAACCCCCGCCCCAGCCGCACCCACCGCCGCCCCAGCAGCAGCACAAGGAAGAGATGGCG
GCCGAGGCTGGGGAAGCCGTGGCGTCCCCCATGGACGACGGGTTTGTGAGCCTGGACTCG
CCCTCCTATGTCCTGTACAGGGACAGAGCAGAATGGGCTGATATAGATCCGGTGCCGCAG
AATGATGGCCCCAATCCCGTGGTCCAGATCATTTATAGTGACAAATTTAGAGATGTTTAT
GATTACTTCCGAGCTGTCCTGCAGCGTGATGAAAGAAGTGAACGAGCTTTTAAGCTAACC
CGGGATGCTATTGAGTTAAATGCAGCCAATTATACAGTGTGGCATTTCCGGAGAGTTCTT
TTGAAGTCACTTCAGAAGGATCTACATGAGGAAATGAACTACATCACTGCAATAATTGAG
GAGCAGCCCAAAAACTATCAAGTTTGGCATCATAGGCGAGTATTAGTGGAATGGCTAAGA
GATCCATCTCAGGAGCTTGAATTTATTGCTGATATTCTTAATCAGGATGCAAAGAATTAT
CATGCCTGGCAGCATCGACAATGGGTTATTCAGGAATTTAAACTTTGGGATAATGAGCTG
CAGTATGTGGACCAACTTCTGAAAGAGGATGTGAGAAATAACTCTGTCTGGAACCAAAGA
TACTTCGTTATTTCTAACACCACTGGCTACAATGATCGTGCTGTATTGGAGAGAGAAGTC
CAATACACTCTGGAAATGATTAAACTAGTACCACATAATGAAAGTGCATGGAACTATTTG
AAAGGGATTTTGCAGGATCGTGGTCTTTCCAAATATCCTAATCTGTTAAATCAATTACTT
GATTTACAACCAAGTCATAGTTCCCCCTACCTAATTGCCTTTCTTGTGGATATCTATGAA
GACATGCTAGAAAATCAGTGTGACAATAAGGAAGACATTCTTAATAAAGCATTAGAGTTA
TGTGAAATCCTAGCTAAAGAAAAGGACACTATAAGAAAGGAATATTGGAGATACATTGGA
AGATCCCTTCAAAGCAAACACAGCACAGAAAATGACTCACCAACAAATGTACAGCAATAA
Protein Properties
Number of Residues 379
Molecular Weight 44408.32
Theoretical pI 5.087
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
MAATEGVGEAAQGGEPGQPAQPPPQPHPPPPQQQHKEEMAAEAGEAVASPMDDGFVSLDS
PSYVLYRDRAEWADIDPVPQNDGPNPVVQIIYSDKFRDVYDYFRAVLQRDERSERAFKLT
RDAIELNAANYTVWHFRRVLLKSLQKDLHEEMNYITAIIEEQPKNYQVWHHRRVLVEWLR
DPSQELEFIADILNQDAKNYHAWQHRQWVIQEFKLWDNELQYVDQLLKEDVRNNSVWNQR
YFVISNTTGYNDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSKYPNLLNQLL
DLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIG
RSLQSKHSTENDSPTNVQQ
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P49354
UniProtKB/Swiss-Prot Entry Name FNTA_HUMAN
PDB IDs
GenBank Gene ID L10413
GeneCard ID FNTA
GenAtlas ID FNTA
HGNC ID HGNC:3782
References
General References Not Available