| Identification |
|---|
| HMDB Protein ID
| CDBP01631 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha |
| Description
| Not Available |
| Synonyms
|
- CAAX farnesyltransferase subunit alpha
- FTase-alpha
- GGTase-I-alpha
- Ras proteins prenyltransferase subunit alpha
- Type I protein geranyl-geranyltransferase subunit alpha
|
| Gene Name
| FNTA |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein prenyltransferase activity |
| Specific Function
| Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity).
|
| GO Classification
|
| Biological Process |
| positive regulation of deacetylase activity |
| positive regulation of tubulin deacetylation |
| protein farnesylation |
| protein geranylgeranylation |
| cellular component disassembly involved in execution phase of apoptosis |
| transforming growth factor beta receptor signaling pathway |
| Cellular Component |
| cytosol |
| microtubule associated complex |
| Function |
| catalytic activity |
| transferase activity |
| protein prenyltransferase activity |
| transferase activity, transferring alkyl or aryl (other than methyl) groups |
| prenyltransferase activity |
| Molecular Function |
| alpha-tubulin binding |
| microtubule binding |
| CAAX-protein geranylgeranyltransferase activity |
| protein farnesyltransferase activity |
| protein geranylgeranyltransferase activity |
| Process |
| metabolic process |
| macromolecule metabolic process |
| protein amino acid lipidation |
| protein prenylation |
| protein amino acid prenylation |
| macromolecule modification |
| protein modification process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Terpenoid backbone biosynthesis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| 8p11 |
| SNPs
| FNTA |
| Gene Sequence
|
>1140 bp
ATGGCGGCCACCGAGGGGGTCGGGGAGGCTGCGCAAGGGGGCGAGCCCGGGCAGCCGGCG
CAACCCCCGCCCCAGCCGCACCCACCGCCGCCCCAGCAGCAGCACAAGGAAGAGATGGCG
GCCGAGGCTGGGGAAGCCGTGGCGTCCCCCATGGACGACGGGTTTGTGAGCCTGGACTCG
CCCTCCTATGTCCTGTACAGGGACAGAGCAGAATGGGCTGATATAGATCCGGTGCCGCAG
AATGATGGCCCCAATCCCGTGGTCCAGATCATTTATAGTGACAAATTTAGAGATGTTTAT
GATTACTTCCGAGCTGTCCTGCAGCGTGATGAAAGAAGTGAACGAGCTTTTAAGCTAACC
CGGGATGCTATTGAGTTAAATGCAGCCAATTATACAGTGTGGCATTTCCGGAGAGTTCTT
TTGAAGTCACTTCAGAAGGATCTACATGAGGAAATGAACTACATCACTGCAATAATTGAG
GAGCAGCCCAAAAACTATCAAGTTTGGCATCATAGGCGAGTATTAGTGGAATGGCTAAGA
GATCCATCTCAGGAGCTTGAATTTATTGCTGATATTCTTAATCAGGATGCAAAGAATTAT
CATGCCTGGCAGCATCGACAATGGGTTATTCAGGAATTTAAACTTTGGGATAATGAGCTG
CAGTATGTGGACCAACTTCTGAAAGAGGATGTGAGAAATAACTCTGTCTGGAACCAAAGA
TACTTCGTTATTTCTAACACCACTGGCTACAATGATCGTGCTGTATTGGAGAGAGAAGTC
CAATACACTCTGGAAATGATTAAACTAGTACCACATAATGAAAGTGCATGGAACTATTTG
AAAGGGATTTTGCAGGATCGTGGTCTTTCCAAATATCCTAATCTGTTAAATCAATTACTT
GATTTACAACCAAGTCATAGTTCCCCCTACCTAATTGCCTTTCTTGTGGATATCTATGAA
GACATGCTAGAAAATCAGTGTGACAATAAGGAAGACATTCTTAATAAAGCATTAGAGTTA
TGTGAAATCCTAGCTAAAGAAAAGGACACTATAAGAAAGGAATATTGGAGATACATTGGA
AGATCCCTTCAAAGCAAACACAGCACAGAAAATGACTCACCAACAAATGTACAGCAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 379 |
| Molecular Weight
| 44408.32 |
| Theoretical pI
| 5.087 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
MAATEGVGEAAQGGEPGQPAQPPPQPHPPPPQQQHKEEMAAEAGEAVASPMDDGFVSLDS
PSYVLYRDRAEWADIDPVPQNDGPNPVVQIIYSDKFRDVYDYFRAVLQRDERSERAFKLT
RDAIELNAANYTVWHFRRVLLKSLQKDLHEEMNYITAIIEEQPKNYQVWHHRRVLVEWLR
DPSQELEFIADILNQDAKNYHAWQHRQWVIQEFKLWDNELQYVDQLLKEDVRNNSVWNQR
YFVISNTTGYNDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSKYPNLLNQLL
DLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIG
RSLQSKHSTENDSPTNVQQ
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P49354 |
| UniProtKB/Swiss-Prot Entry Name
| FNTA_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| L10413 |
| GeneCard ID
| FNTA |
| GenAtlas ID
| FNTA |
| HGNC ID
| HGNC:3782 |
| References |
|---|
| General References
| Not Available |