Showing Protein Phosphate-regulating neutral endopeptidase (CDBP01618)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 compounds
Identification
HMDB Protein ID CDBP01618
Secondary Accession Numbers Not Available
Name Phosphate-regulating neutral endopeptidase
Description Not Available
Synonyms
  1. HYP
  2. Metalloendopeptidase homolog PEX
  3. Vitamin D-resistant hypophosphatemic rickets protein
  4. X-linked hypophosphatemia protein
Gene Name PHEX
Protein Type Enzyme
Biological Properties
General Function Involved in metalloendopeptidase activity
Specific Function Probably involved in bone and dentin mineralization and renal phosphate reabsorption
GO Classification
Function
endopeptidase activity
catalytic activity
hydrolase activity
metalloendopeptidase activity
peptidase activity
peptidase activity, acting on l-amino acid peptides
metallopeptidase activity
Process
metabolic process
macromolecule metabolic process
protein metabolic process
proteolysis
Cellular Location
  1. Membrane
  2. Single-pass type II membrane protein (Potential)
Pathways
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs PHEX
Gene Sequence 
>2250 bp
ATGGAAGCAGAAACAGGGAGCAGCGTGGAGACTGGAAAGAAGGCCAACAGAGGCACTCGA
ATTGCCCTGGTCGTGTTTGTCGGTGGCACCCTAGTTCTGGGCACGATCCTCTTTCTAGTG
AGTCAAGGTCTCTTAAGTCTCCAAGCTAAACAGGAGTACTGCCTGAAGCCAGAATGCATC
GAAGCGGCTGCTGCCATCTTAAGTAAAGTAAATCTGTCTGTGGATCCTTGTGATAATTTC
TTCCGGTTCGCTTGTGATGGCTGGATAAGCAATAATCCAATTCCCGAAGATATGCCAAGC
TATGGGGTTTATCCTTGGCTGAGACATAATGTTGACCTCAAGTTGAAGGAACTTTTGGAG
AAATCAATCAGTAGAAGGCGGGACACCGAAGCCATACAGAAAGCCAAAATCCTTTATTCA
TCCTGCATGAATGAGAAAGCGATTGAAAAAGCAGATGCCAAGCCACTGCTACACATCCTA
CGGCATTCACCTTTCCGCTGGCCCGTGCTTGAATCTAATATTGGCCCTGAAGGGGTTTGG
TCAGAGAGAAAGTTCAGCCTTCTGCAGACACTTGCAACGTTTCGTGGTCAATACAGCAAT
TCTGTGTTCATCCGTTTGTATGTGTCCCCTGATGACAAAGCATCCAATGAACATATCTTG
AAGCTGGACCAAGCAACACTCTCCCTGGCCGTGAGGGAAGACTACCTTGATAACAGTACA
GAAGCCAAGTCTTATCGGGATGCCCTTTACAAGTTCATGGTGGATACTGCCGTGCTTTTA
GGAGCTAACAGTTCCAGAGCAGAGCATGACATGAAGTCAGTGCTCAGATTGGAAATTAAG
ATAGCTGAGATAATGATTCCACATGAAAACCGAACCAGCGAGGCCATGTACAACAAAATG
AACATTTCTGAACTGAGTGCTATGATTCCCCAGTTCGACTGGCTGGGCTACATCAAGAAG
GTCATTGACACCAGACTCTACCCCCATCTGAAAGACATCAGCCCCTCCGAGAATGTGGTG
GTCCGCGTCCCGCAGTACTTTAAAGATTTGTTTAGGATATTAGGGTCTGAGAGAAAGAAG
ACCATTGCCAACTATTTGGTGTGGAGAATGGTTTATTCCAGAATTCCAAACCTTAGCAGG
CGCTTTCAGTATAGATGGCTGGAATTCTCAAGGGTAATCCAGGGGACCACAACTTTGCTG
CCTCAATGGGACAAATGTGTAAACTTTATTGAAAGTGCCCTCCCTTATGTTGTTGGAAAG
ATGTTTGTAGATGTGTACTTCCAGGAAGATAAGAAGGAAATGATGGAGGAATTGGTTGAG
GGCGTTCGCTGGGCCTTTATTGACATGCTAGAGAAAGAAAATGAGTGGATGGATGCAGGA
ACGAAAAGGAAAGCCAAAGAAAAGGCGAGAGCTGTTTTGGCAAAAGTTGGCTATCCAGAG
TTTATAATGAATGATACTCATGTTAATGAAGACCTCAAAGCTATCAAGTTTTCAGAAGCC
GACTACTTTGGCAACGTCCTACAAACTCGCAAGTATTTAGCACAGTCTGATTTCTTCTGG
CTAAGAAAAGCCGTTCCAAAAACAGAGTGGTTTACAAATCCGACGACTGTCAATGCCTTC
TACAGTGCATCCACCAACCAGATCCGATTTCCAGCAGGAGAGCTCCAGAAGCCTTTCTTT
TGGGGAACAGAATATCCTCGATCTCTGAGTTATGGTGCTATAGGAGTAATTGTCGGACAT
GAATTTACACATGGATTTGATAATAATGGTAGAAAATATGATAAAAATGGAAACCTGGAT
CCTTGGTGGTCTACTGAATCAGAAGAAAAGTTTAAGGAAAAAACAAAATGCATGATTAAC
CAGTATAGCAACTATTATTGGAAGAAAGCTGGCTTAAATGTCAAGGGGAAGAGGACCCTG
GGAGAAAATATTGCTGATAATGGAGGCCTGCGGGAAGCTTTTAGGGCTTACAGGAAATGG
ATAAATGACAGAAGGCAGGGACTTGAGGAGCCTCTTCTACCAGGCATCACATTCACCAAC
AACCAGCTCTTCTTCCTGAGTTATGCTCATGTGAGGTGCAATTCCTACAGACCAGAAGCT
GCCCGAGAACAAGTCCAAATTGGTGCTCACAGTCCCCCTCAGTTTAGGGTCAATGGTGCA
ATTAGTAACTTTGAAGAATTCCAGAAAGCTTTTAACTGTCCACCCAATTCCACGATGAAC
AGAGGCATGGACTCCTGCCGACTCTGGTAG
Protein Properties
Number of Residues 749
Molecular Weight 86473.2
Theoretical pI 9.05
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["21-41"]
Protein Sequence 
>Phosphate-regulating neutral endopeptidase
MEAETGSSVETGKKANRGTRIALVVFVGGTLVLGTILFLVSQGLLSLQAKQEYCLKPECI
EAAAAILSKVNLSVDPCDNFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKELLE
KSISRRRDTEAIQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLESNIGPEGVW
SERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDYLDNST
EAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYNKM
NISELSAMIPQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKK
TIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGK
MFVDVYFQEDKKEMMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKVGYPE
FIMNDTHVNEDLKAIKFSEADYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAF
YSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLD
PWWSTESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKW
INDRRQGLEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGA
ISNFEEFQKAFNCPPNSTMNRGMDSCRLW
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P78562
UniProtKB/Swiss-Prot Entry Name PHEX_HUMAN
PDB IDs Not Available
GenBank Gene ID U75645
GeneCard ID PHEX
GenAtlas ID PHEX
HGNC ID HGNC:8918
References
General References Not Available