| Identification |
| HMDB Protein ID
| CDBP01604 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cell division control protein 42 homolog |
| Description
| Not Available |
| Synonyms
|
- G25K GTP-binding protein
|
| Gene Name
| CDC42 |
| Protein Type
| Enzyme |
| Biological Properties |
| General Function
| Involved in GTP binding |
| Specific Function
| Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Causes the formation of thin, actin-rich surface projections called filopodia |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| guanyl nucleotide binding |
| guanyl ribonucleotide binding |
| gtp binding |
| purine nucleotide binding |
| binding |
| nucleotide binding |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| signal transduction |
| intracellular signal transduction |
| small gtpase mediated signal transduction |
|
| Cellular Location
|
- Cell membrane
- Lipid-anchor
- Cytoplasmic side (Potential)
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine |    | Not Available | | Intracellular Signalling Through Adenosine Receptor A2b and Adenosine |    | Not Available |
|
| Gene Properties |
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p36.1 |
| SNPs
| CDC42 |
| Gene Sequence
|
>576 bp
ATGCAGACAATTAAGTGTGTTGTTGTGGGCGATGGTGCTGTTGGTAAAACATGTCTCCTG
ATATCCTACACAACAAACAAATTTCCATCGGAATATGTACCGACTGTTTTTGACAACTAT
GCAGTCACAGTTATGATTGGTGGAGAACCATATACTCTTGGACTTTTTGATACTGCAGGG
CAAGAGGATTATGACAGATTACGACCGCTGAGTTATCCACAAACAGATGTATTTCTAGTC
TGTTTTTCAGTGGTCTCTCCATCTTCATTTGAAAACGTGAAAGAAAAGTGGGTGCCTGAG
ATAACTCACCACTGTCCAAAGACTCCTTTCTTGCTTGTTGGGACTCAAATTGATCTCAGA
GATGACCCCTCTACTATTGAGAAACTTGCCAAGAACAAACAGAAGCCTATCACTCCAGAG
ACTGCTGAAAAGCTGGCCCGTGACCTGAAGGCTGTCAAGTATGTGGAGTGTTCTGCACTT
ACACAGAGAGGTCTGAAGAATGTGTTTGATGAGGCTATCCTAGCTGCCCTCGAGCCTCCG
GAAACTCAACCCAAAAGGAAGTGCTGTATATTCTAA
|
| Protein Properties |
| Number of Residues
| 191 |
| Molecular Weight
| 21310.4 |
| Theoretical pI
| 5.83 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cell division control protein 42 homolog
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG
QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR
DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPP
ETQPKRKCCIF
|
| External Links |
| GenBank ID Protein
| 182857 |
| UniProtKB/Swiss-Prot ID
| P60953 |
| UniProtKB/Swiss-Prot Entry Name
| CDC42_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| M35543 |
| GeneCard ID
| CDC42 |
| GenAtlas ID
| CDC42 |
| HGNC ID
| HGNC:1736 |
| References |
| General References
| Not Available |