| Identification |
|---|
| HMDB Protein ID
| CDBP01602 |
| Secondary Accession Numbers
| Not Available |
| Name
| Rab GDP dissociation inhibitor alpha |
| Description
| Not Available |
| Synonyms
|
- GDI-1
- Guanosine diphosphate dissociation inhibitor 1
- Oligophrenin-2
- Protein XAP-4
- Rab GDI alpha
|
| Gene Name
| GDI1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in regulation of GTPase activity |
| Specific Function
| Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them |
| GO Classification
|
| Function |
| small gtpase regulator activity |
| enzyme regulator activity |
| gdp-dissociation inhibitor activity |
| rab gdp-dissociation inhibitor activity |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| Process |
| regulation of cellular metabolic process |
| regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
| regulation of nucleotide metabolic process |
| regulation of nucleotide catabolic process |
| regulation of purine nucleotide catabolic process |
| regulation of gtp catabolic process |
| regulation of gtpase activity |
| establishment of localization |
| transport |
| protein transport |
| biological regulation |
| regulation of biological process |
| regulation of metabolic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| GDI1 |
| Gene Sequence
|
>1344 bp
ATGGACGAGGAATACGATGTGATCGTGCTGGGGACCGGTCTCACCGAATGCATCCTGTCG
GGCATCATGTCTGTGAACGGGAAGAAGGTGCTGCACATGGACCGGAACCCCTACTACGGG
GGCGAGAGCTCCTCCATCACACCCCTGGAGGAGCTGTATAAGCGTTTTCAGTTGCTGGAG
GGGCCCCCTGAGTCGATGGGCCGAGGCCGAGACTGGAATGTTGACCTGATTCCCAAATTC
CTCATGGCTAACGGGCAGCTGGTAAAGATGCTACTGTATACAGAGGTGACTCGCTACCTG
GACTTCAAGGTGGTGGAGGGCAGCTTTGTCTACAAGGGGGGCAAGATCTACAAAGTGCCG
TCCACTGAGACTGAGGCCTTGGCTTCCAATCTGATGGGCATGTTTGAGAAACGGCGCTTC
CGCAAGTTCCTGGTGTTTGTGGCAAACTTCGATGAGAATGACCCCAAGACCTTTGAGGGC
GTTGACCCCCAGACTACCAGCATGCGTGACGTCTACCGGAAGTTTGATCTGGGCCAGGAT
GTCATCGATTTCACTGGCCATGCCCTGGCGCTCTACCGCACTGATGACTACCTGGACCAG
CCCTGCCTTGAGACCGTCAACCGCATCAAGTTGTACAGTGAGTCCCTGGCCCGGTATGGC
AAGAGCCCATATTTATACCCGCTCTACGGCTTGGGCGAGCTGCCCCAGGGTTTTGCAAGA
TTGAGTGCCATCTATGGGGGGACATATATGCTGAACAAACCTGTGGATGACATCATCATG
GAGAACGGCAAGGTGGTGGGCGTGAAGTCTGAGGGAGAGGTGGCCCGCTGCAAGCAGCTG
ATCTGTGACCCCAGCTACATCCCGGACCGTGTGCGGAAGGCTGGCCAGGTTATCCGCATC
ATCTGTATCCTTAGCCACCCCATCAAGAACACCAACGACGCCAACTCCTGCCAAATAATC
ATCCCCCAGAACCAGGTCAACAGGAAGTCAGACATCTACGTGTGCATGATCTCCTATGCA
CACAACGTGGCGGCCCAGGGCAAGTACATAGCTATTGCCAGCACTACTGTGGAGACCACG
GACCCTGAAAAGGAGGTGGAGCCGGCTCTGGAGCTGTTGGAGCCCATTGACCAGAAGTTT
GTGGCTATCAGTGACTTGTATGAGCCCATTGATGATGGTTGTGAGAGCCAGGTGTTCTGT
TCCTGCTCCTACGATGCCACCACACACTTTGAGACAACCTGCAACGACATCAAAGACATC
TACAAACGCATGGCTGGCACGGCCTTTGACTTTGAGAACATGAAGCGCAAACAGAACGAC
GTCTTTGGAGAAGCTGAGCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 447 |
| Molecular Weight
| 50582.3 |
| Theoretical pI
| 4.75 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Rab GDP dissociation inhibitor alpha
MDEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESSSITPLEELYKRFQLLE
GPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTRYLDFKVVEGSFVYKGGKIYKVP
STETEALASNLMGMFEKRRFRKFLVFVANFDENDPKTFEGVDPQTTSMRDVYRKFDLGQD
VIDFTGHALALYRTDDYLDQPCLETVNRIKLYSESLARYGKSPYLYPLYGLGELPQGFAR
LSAIYGGTYMLNKPVDDIIMENGKVVGVKSEGEVARCKQLICDPSYIPDRVRKAGQVIRI
ICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISYAHNVAAQGKYIAIASTTVETT
DPEKEVEPALELLEPIDQKFVAISDLYEPIDDGCESQVFCSCSYDATTHFETTCNDIKDI
YKRMAGTAFDFENMKRKQNDVFGEAEQ
|
| External Links |
|---|
| GenBank ID Protein
| 695585 |
| UniProtKB/Swiss-Prot ID
| P31150 |
| UniProtKB/Swiss-Prot Entry Name
| GDIA_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| X79353 |
| GeneCard ID
| GDI1 |
| GenAtlas ID
| GDI1 |
| HGNC ID
| HGNC:4226 |
| References |
|---|
| General References
| Not Available |