| Identification |
|---|
| HMDB Protein ID
| CDBP01600 |
| Secondary Accession Numbers
| Not Available |
| Name
| Rho GDP-dissociation inhibitor 3 |
| Description
| Not Available |
| Synonyms
|
- Rho GDI 3
- Rho-GDI gamma
|
| Gene Name
| ARHGDIG |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in Rho GDP-dissociation inhibitor activity |
| Specific Function
| Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post- translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP |
| GO Classification
|
| Component |
| cell part |
| intracellular part |
| cytoplasm |
| Function |
| enzyme regulator activity |
| gdp-dissociation inhibitor activity |
| rho gdp-dissociation inhibitor activity |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| small gtpase regulator activity |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 16p13.3 |
| SNPs
| ARHGDIG |
| Gene Sequence
|
>678 bp
ATGCTGGGCCTGGACGCGTGCGAGCTGGGGGCGCAGCTGCTGGAGCTGCTCCGGCTGGCG
CTGTGCGCCCGAGTCCTCCTGGCTGACAAGGAGGGTGGGCCGCCGGCAGTGGACGAGGTG
TTGGATGAGGCTGTGCCCGAGTACCGGGCGCCGGGGAGGAAGAGCCTCTTGGAGATCCGG
CAGCTGGACCCGGACGACAGGAGCCTGGCCAAGTACAAGCGGGTGCTGCTGGGGCCCCTG
CCACCGGCCGTGGACCCAAGCCTGCCCAATGTGCAGGTGACCAGGCTGACACTCCTGTCG
GAACAGGCTCCGGGGCCCGTCGTCATGGATCTCACAGGGGACCTGGCTGTTCTGAAGGAC
CAGGTGTTTGTCCTGAAGGAAGGTGTTGATTACAGAGTGAAGATCTCCTTCAAGGTCCAC
AGGGAGATTGTCAGCGGCCTCAAGTGTCTGCACCACACCTACCGCCGGGGCCTGCGCGTG
GACAAGACCGTCTACATGGTGGGCAGCTATGGCCCGAGCGCCCAGGAGTATGAGTTTGTG
ACTCCGGTGGAGGAAGCGCCGAGGGGTGCGCTGGTGCGGGGCCCCTATCTGGTGGTGTCC
CTCTTCACCGACGATGACAGGACGCACCACCTGTCCTGGGAGTGGGGTCTCTGCATCTGC
CAGGACTGGAAGGACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 225 |
| Molecular Weight
| 25097.8 |
| Theoretical pI
| 5.37 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Rho GDP-dissociation inhibitor 3
MLGLDACELGAQLLELLRLALCARVLLADKEGGPPAVDEVLDEAVPEYRAPGRKSLLEIR
QLDPDDRSLAKYKRVLLGPLPPAVDPSLPNVQVTRLTLLSEQAPGPVVMDLTGDLAVLKD
QVFVLKEGVDYRVKISFKVHREIVSGLKCLHHTYRRGLRVDKTVYMVGSYGPSAQEYEFV
TPVEEAPRGALVRGPYLVVSLFTDDDRTHHLSWEWGLCICQDWKD
|
| External Links |
|---|
| GenBank ID Protein
| 82941188 |
| UniProtKB/Swiss-Prot ID
| Q99819 |
| UniProtKB/Swiss-Prot Entry Name
| GDIR3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB127078 |
| GeneCard ID
| ARHGDIG |
| GenAtlas ID
| ARHGDIG |
| HGNC ID
| HGNC:680 |
| References |
|---|
| General References
| Not Available |