| Identification |
|---|
| HMDB Protein ID
| CDBP01599 |
| Secondary Accession Numbers
| Not Available |
| Name
| Rap1 GTPase-GDP dissociation stimulator 1 |
| Description
| Not Available |
| Synonyms
|
- Exchange factor smgGDS
- SMG GDS protein
- SMG P21 stimulatory GDP/GTP exchange protein
|
| Gene Name
| RAP1GDS1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein |
| GO Classification
|
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:4 |
| Locus
| 4q23-q25 |
| SNPs
| RAP1GDS1 |
| Gene Sequence
|
>1824 bp
ATGGATAATCTCAGTGATACCTTGAAGAAGCTGAAGATAACAGCTGTTGACAAGACTGAG
GATAGTTTAGAAGGATGCTTGGATTGTCTGCTTCAAGCCCTGGCTCAAAATAATACGGAA
ACAAGTGAAAAAATCCAAGCAAGTGGAATACTTCAGCTGTTTGCAAGTCTGTTGACTCCA
CAGTCTTCCTGCAAAGCCAAAGTAGCTAACATCATAGCAGAAGTAGCCAAAAATGAGTTT
ATGCGAATTCCATGTGTGGATGCTGGATTGATTTCACCACTGGTGCAGCTGCTAAATAGC
AAAGACCAGGAAGTGCTGCTTCAAACGGGCAGGGCTCTAGGAAACATATGTTACGATAGC
CATGAGGGCAGAAGTGCAGTTGACCAAGCAGGTGGTGCACAGATTGTAATTGACCATTTA
AGGTCACTGTGCAGTATAACAGATCCCGCCAATGAGAAGCTCTTGACTGTCTTTTGTGGC
ATGCTGATGAACTATAGCAATGAGAATGATTCGCTTCAAGCTCAGCTTATCAATATGGGT
GTTATTCCTACCTTAGTGAAATTACTGGGCATCCACTGCCAAAATGCAGCTCTTACAGAA
ATGTGTCTTGTTGCATTTGGTAATTTAGCAGAACTTGAGTCAAGTAAAGAACAGTTTGCC
AGTACAAACATTGCTGAAGAGCTAGTAAAACTCTTCAAGAAACAAATAGAACATGATAAG
AGAGAAATGATTTTTGAAGTTCTTGCTCCATTGGCAGAAAATGATGCTATTAAACTACAG
CTGGTTGAAGCAGGCCTAGTAGAGTGTCTACTAGAGATTGTTCAGCAAAAAGTGGATAGT
GACAAAGAAGATGATATTACTGAGCTCAAAACTGGTTCAGATCTCATGGTTTTATTACTT
CTTGGAGATGAATCCATGCAGAAGTTATTTGAAGGAGGAAAAGGTAGTGTATTTCAAAGG
GTACTCTCTTGGATCCCATCAAATAACCACCAGCTACAGCTTGCTGGAGCATTGGCAATT
GCAAATTTTGCCAGAAATGATGCAAATTGTATTCATATGGTAGACAATGGGATTGTAGAA
AAACTTATGGATTTACTGGACAGACATGTAGAAGATGGAAATGTAACAGTACAGCATGCA
GCACTAAGTGCCCTCAGAAACCTGGCCATTCCAGTTATAAATAAAGCAAAGATGTTATCA
GCTGGGGTCACAGAGGCAGTTTTGAAATTTCTTAAATCTGAAATGCCTCCTGTTCAGTTC
AAACTTCTGGGAACATTAAGAATGTTAATAGATGCACAAGCAGAAGCTGCTGAACAATTG
GGAAAGAATGTTAAGTTAGTGGAGCGTTTGGTGGAATGGTGTGAAGCCAAAGATCATGCT
GGTGTGATGGGGGAGTCAAACAGACTGCTGTCTGCCCTTATACGACACAGTAAATCAAAA
GATGTAATTAAAACCATTGTGCAGAGTGGTGGCATCAAGCATCTAGTTACCATGGCAACT
AGTGAACATGTAATAATGCAGAATGAAGCTCTTGTTGCTTTGGCATTAATAGCAGCTTTA
GAATTGGGCACTGCTGAGAAAGATCTAGAAAGTGCTAAACTTGTACAGATTTTACATAGA
CTGCTAGCAGATGAGAGAAGTGCTCCTGAAATCAAATATAATTCCATGGTCCTGATATGT
GCTCTTATGGGATCTGAATGTCTACACAAGGAAGTACAGGATTTGGCTTTTCTAGATGTC
GTATCCAAACTTCGCAGTCATGAGAACAAAAGTGTTGCCCAGCAGGCCTCTCTCACAGAG
CAGAGACTTACTGTGGAAAGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 607 |
| Molecular Weight
| 66316.2 |
| Theoretical pI
| 4.97 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Rap1 GTPase-GDP dissociation stimulator 1
MDNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLTP
QSSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDS
HEGRSAVDQAGGAQIVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMG
VIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDK
REMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLL
LGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVE
KLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQF
KLLGTLRMLIDAQAEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSK
DVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHR
LLADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLTE
QRLTVES
|
| External Links |
|---|
| GenBank ID Protein
| 155030196 |
| UniProtKB/Swiss-Prot ID
| P52306 |
| UniProtKB/Swiss-Prot Entry Name
| GDS1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001100427.1 |
| GeneCard ID
| RAP1GDS1 |
| GenAtlas ID
| RAP1GDS1 |
| HGNC ID
| HGNC:9859 |
| References |
|---|
| General References
| Not Available |