| Identification |
|---|
| HMDB Protein ID
| CDBP01587 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cytochrome c |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| CYCS |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in iron ion binding |
| Specific Function
| Plays a role in apoptosis. Suppression of the anti- apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases |
| GO Classification
|
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| electron carrier activity |
| iron ion binding |
| heme binding |
|
| Cellular Location
|
- Mitochondrion matrix
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Mitochondrial Electron Transport Chain |    |  |
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:7 |
| Locus
| 7p15.3 |
| SNPs
| CYCS |
| Gene Sequence
|
>318 bp
ATGGGTGATGTTGAGAAAGGCAAGAAGATTTTTATTATGAAGTGTTCCCAGTGCCACACC
GTTGAAAAGGGAGGCAAGCACAAGACTGGGCCAAATCTCCATGGTCTCTTTGGGCGGAAG
ACAGGTCAGGCCCCTGGATACTCTTACACAGCCGCCAATAAGAACAAAGGCATCATCTGG
GGAGAGGATACACTGATGGAGTATTTGGAGAATCCCAAGAAGTACATCCCTGGAACAAAA
ATGATCTTTGTCGGCATTAAGAAGAAGGAAGAAAGGGCAGACTTAATAGCTTATCTCAAA
AAAGCTACTAATGAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 105 |
| Molecular Weight
| 11748.7 |
| Theoretical pI
| 10.16 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cytochrome c
MGDVEKGKKIFIMKCSQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGYSYTAANKNKGIIW
GEDTLMEYLENPKKYIPGTKMIFVGIKKKEERADLIAYLKKATNE
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P99999 |
| UniProtKB/Swiss-Prot Entry Name
| CYC_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| BT006946 |
| GeneCard ID
| CYCS |
| GenAtlas ID
| CYCS |
| HGNC ID
| HGNC:19986 |
| References |
|---|
| General References
| Not Available |