| Identification |
|---|
| HMDB Protein ID
| CDBP01580 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cation-dependent mannose-6-phosphate receptor |
| Description
| Not Available |
| Synonyms
|
- 46 kDa mannose 6-phosphate receptor
- CD Man-6-P receptor
- CD-MPR
- MPR 46
|
| Gene Name
| M6PR |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| integral to membrane |
| vacuole |
| lytic vacuole |
| Function |
| binding |
| protein binding |
| carbohydrate transmembrane transporter activity |
| sugar transmembrane transporter activity |
| monosaccharide transmembrane transporter activity |
| hexose transmembrane transporter activity |
| mannose transmembrane transporter activity |
| monosaccharide binding |
| mannose binding |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| transporter activity |
| carbohydrate binding |
| sugar binding |
| Process |
| carbohydrate transport |
| monosaccharide transport |
| hexose transport |
| mannose transport |
| establishment of localization |
| transport |
|
| Cellular Location
|
- Single-pass type I membrane protein
- Lysosome membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12p13 |
| SNPs
| M6PR |
| Gene Sequence
|
>834 bp
ATGTTCCCTTTCTACAGCTGCTGGAGGACTGGACTGCTACTACTACTCCTGGCTGTGGCA
GTGAGAGAATCCTGGCAGACAGAAGAAAAAACTTGCGACTTGGTAGGAGAAAAGGGTAAA
GAGTCAGAGAAAGAGTTGGCTCTAGTGAAGAGGCTGAAACCACTGTTTAATAAAAGCTTT
GAGAGCACTGTGGGCCAGGGTTCAGACACATACATCTACATCTTCAGGGTGTGCCGGGAA
GCTGGCAACCACACTTCTGGGGCAGGCCTGGTGCAAATCAACAAAAGTAATGGGAAGGAG
ACAGTGGTAGGGAGACTCAACGAGACTCACATCTTCAACGGAAGTAATTGGATCATGCTG
ATCTATAAAGGGGGTGATGAATATGACAACCACTGTGGCAAGGAGCAGCGTCGTGCAGTG
GTGATGATCTCCTGCAATCGACACACCCTAGCGGACAATTTTAACCCTGTGTCTGAGGAG
CGTGGCAAAGTCCAAGATTGTTTCTACCTCTTTGAGATGGATAGCAGCCTGGCCTGTTCA
CCAGAGATCTCCCACCTCAGTGTGGGTTCCATCTTACTTGTCACGTTTGCATCACTGGTT
GCTGTTTATGTTGTTGGGGGGTTCCTATACCAGCGACTGGTAGTGGGAGCCAAAGGAATG
GAGCAGTTTCCCCACTTAGCCTTCTGGCAGGATCTTGGCAACCTGGTAGCAGATGGCTGT
GACTTTGTCTGCCGTTCTAAACCTCGAAATGTGCCTGCAGCATATCGTGGTGTGGGGGAT
GACCAGCTGGGGGAGGAGTCAGAAGAAAGGGATGACCATTTATTACCAATGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 277 |
| Molecular Weight
| 30993.1 |
| Theoretical pI
| 5.64 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cation-dependent mannose-6-phosphate receptor
MFPFYSCWRTGLLLLLLAVAVRESWQTEEKTCDLVGEKGKESEKELALVKRLKPLFNKSF
ESTVGQGSDTYIYIFRVCREAGNHTSGAGLVQINKSNGKETVVGRLNETHIFNGSNWIML
IYKGGDEYDNHCGKEQRRAVVMISCNRHTLADNFNPVSEERGKVQDCFYLFEMDSSLACS
PEISHLSVGSILLVTFASLVAVYVVGGFLYQRLVVGAKGMEQFPHLAFWQDLGNLVADGC
DFVCRSKPRNVPAAYRGVGDDQLGEESEERDDHLLPM
|
| External Links |
|---|
| GenBank ID Protein
| 307147 |
| UniProtKB/Swiss-Prot ID
| P20645 |
| UniProtKB/Swiss-Prot Entry Name
| MPRD_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| M16985 |
| GeneCard ID
| M6PR |
| GenAtlas ID
| M6PR |
| HGNC ID
| HGNC:6752 |
| References |
|---|
| General References
| Not Available |