| Identification |
|---|
| HMDB Protein ID
| CDBP01574 |
| Secondary Accession Numbers
| Not Available |
| Name
| Transcobalamin-2 |
| Description
| Not Available |
| Synonyms
|
- TC II
- TC-2
- TCII
- Transcobalamin II
|
| Gene Name
| TCN2 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in cobalamin binding |
| Specific Function
| Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells |
| GO Classification
|
| Function |
| binding |
| cobalamin binding |
| vitamin binding |
| Process |
| establishment of localization |
| transport |
| vitamin transport |
| cobalamin transport |
|
| Cellular Location
|
- Secreted
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 22q12.2 |
| SNPs
| TCN2 |
| Gene Sequence
|
>1284 bp
ATGAGGCACCTTGGGGCCTTCCTCTTCCTTCTGGGGGTCCTGGGGGCCCTCACTGAGATG
TGTGAAATACCAGAGATGGACAGCCATCTGGTAGAGAAGTTGGGCCAGCACCTCTTACCT
TGGATGGACCGGCTTTCCCTGGAGCACTTGAACCCCAGCATCTATGTGGGCCTACGCCTC
TCCAGTCTGCAGGCTGGGACCAAGGAAGACCTCTACCTGCACAGCCTCAAGCTTGGTTAC
CAGCAGTGCCTCCTAGGGTCTGCCTTCAGCGAGGATGACGGTGACTGCCAGGGCAAGCCT
TCCATGGGCCAGCTGGCCCTCTACCTGCTCGCTCTCAGAGCCAACTGTGAGTTTGTCAGG
GGCCACAAGGGGGACAGGCTGGTCTCACAGCTCAAATGGTTCCTGGAGGATGAGAAGAGA
GCCATTGGGCATGATCACAAGGGCCACCCCCACACTAGCTACTACCAGTATGGCCTGGGC
ATTCTGGCCCTGTGTCTCCACCAGAAGCGGGTCCATGACAGCGTGGTGGACAAACTTCTG
TATGCTGTGGAACCTTTCCACCAGGGCCACCATTCTGTGGACACAGCAGCCATGGCAGGC
TTGGCATTCACCTGTCTGAAGCGCTCAAACTTCAACCCTGGTCGGAGACAACGGATCACC
ATGGCCATCAGAACAGTGCGAGAGGAGATCTTGAAGGCCCAGACCCCCGAGGGCCACTTT
GGGAATGTCTACAGCACCCCATTGGCATTACAGTTCCTCATGACTTCCCCCATGCCTGGG
GCAGAACTGGGAACAGCATGTCTCAAGGCGAGGGTTGCTTTGCTGGCCAGTCTGCAGGAT
GGAGCCTTCCAGAATGCTCTCATGATTTCCCAGCTGCTGCCCGTTCTGAACCACAAGACC
TACATTGATCTGATCTTCCCAGACTGTCTGGCACCACGAGTCATGTTGGAACCAGCTGCT
GAGACCATTCCTCAGACCCAAGAGATCATCAGTGTCACGCTGCAGGTGCTTAGTCTCTTG
CCGCCGTACAGACAGTCCATCTCTGTTCTGGCCGGGTCCACCGTGGAAGATGTCCTGAAG
AAGGCCCATGAGTTAGGAGGATTCACATATGAAACACAGGCCTCCTCGTCAGGCCCCTAC
TTAACCTCCGTGATGGGGAAAGCGGCCGGAGAAAGGGAGTTCTGGCAGCTTCTCCGAGAC
CCCAACACCCCACTGTTGCAAGGTATTGCTGACTACAGACCCAAGGATGGAGAAACCATT
GAGCTGAGGCTGGTTAGCTGGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 427 |
| Molecular Weight
| 47534.5 |
| Theoretical pI
| 7.01 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Transcobalamin-2
MRHLGAFLFLLGVLGALTEMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSIYVGLRL
SSLQAGTKEDLYLHSLKLGYQQCLLGSAFSEDDGDCQGKPSMGQLALYLLALRANCEFVR
GHKGDRLVSQLKWFLEDEKRAIGHDHKGHPHTSYYQYGLGILALCLHQKRVHDSVVDKLL
YAVEPFHQGHHSVDTAAMAGLAFTCLKRSNFNPGRRQRITMAIRTVREEILKAQTPEGHF
GNVYSTPLALQFLMTSPMRGAELGTACLKARVALLASLQDGAFQNALMISQLLPVLNHKT
YIDLIFPDCLAPRVMLEPAAETIPQTQEIISVTLQVLSLLPPYRQSISVLAGSTVEDVLK
KAHELGGFTYETQASLSGPYLTSVMGKAAGEREFWQLLRDPNTPLLQGIADYRPKDGETI
ELRLVSW
|
| External Links |
|---|
| GenBank ID Protein
| 339196 |
| UniProtKB/Swiss-Prot ID
| P20062 |
| UniProtKB/Swiss-Prot Entry Name
| TCO2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| M60396 |
| GeneCard ID
| TCN2 |
| GenAtlas ID
| TCN2 |
| HGNC ID
| HGNC:11653 |
| References |
|---|
| General References
| Not Available |