| Identification |
|---|
| HMDB Protein ID
| CDBP01565 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ganglioside GM2 activator |
| Description
| Not Available |
| Synonyms
|
- Cerebroside sulfate activator protein
- GM2-AP
- Ganglioside GM2 activator isoform short
- SAP-3
- Shingolipid activator protein 3
|
| Gene Name
| GM2A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in sphingolipid activator protein activity |
| Specific Function
| Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3 |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Lysosome
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q33.1 |
| SNPs
| GM2A |
| Gene Sequence
|
>582 bp
ATGCAGTCCCTGATGCAGGCTCCCCTCCTGATCGCCCTGGGCTTGCTTCTCGCGACCCCT
GCGCAAGCCCACCTGAAAAAGCCATCCCAGCTCAGTAGCTTTTCCTGGGATAACTGTGAT
GAAGGGAAGGACCCTGCGGTGATCAGAAGCCTGACTCTGGAGCCTGACCCCATCGTCGTT
CCTGGAAATGTGACCCTCAGTGTCGTGGGCAGCACCAGTGTCCCCCTGAGTTCTCCTCTG
AAGGTGGATTTAGTTTTGGAGAAGGAGGTGGCTGGCCTCTGGATCAAGATCCCATGCACA
GACTACATTGGCAGCTGTACCTTTGAACACTTCTGTGATGTGCTTGACATGTTAATTCCT
ACTGGGGAGCCCTGCCCAGAGCCCCTGCGTACCTATGGGCTTCCTTGCCACTGTCCCTTC
AAAGAAGGAACCTACTCACTGCCCAAGAGCGAATTCGTTGTGCCTGACCTGGAGCTGCCC
AGTTGGCTCACCACCGGGAACTACCGCATAGAGAGCGTCCTGAGCAGCAGTGGGAAGCGT
CTGGGCTGCATCAAGATCGCTGCCTCTCTAAAGGGCATATAG
|
| Protein Properties |
|---|
| Number of Residues
| 193 |
| Molecular Weight
| 20838.1 |
| Theoretical pI
| 4.96 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ganglioside GM2 activator
MQSLMQAPLLIALGLLLAAPAQAHLKKPSQLSSFSWDNCDEGKDPAVIRSLTLEPDPIIV
PGNVTLSVMGSTSVPLSSPLKVDLVLEKEVAGLWIKIPCTDYIGSCTFEHFCDVLDMLIP
TGEPCPEPLRTYGLPCHCPFKEGTYSLPKSEFVVPDLELPSWLTTGNYRIESVLSSSGKR
LGCIKIAASLKGI
|
| External Links |
|---|
| GenBank ID Protein
| 4587479 |
| UniProtKB/Swiss-Prot ID
| P17900 |
| UniProtKB/Swiss-Prot Entry Name
| SAP3_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF124719 |
| GeneCard ID
| GM2A |
| GenAtlas ID
| GM2A |
| HGNC ID
| HGNC:4367 |
| References |
|---|
| General References
| Not Available |