Cannabis Compound Database: Showing Protein Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (CDBP01559)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP01559

Secondary Accession Numbers

Not Available

Name

Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

Description

Not Available

Synonyms

GNT-III
GlcNAc-T III
N-acetylglucosaminyltransferase III
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III

Gene Name

MGAT3

Protein Type

Enzyme

Biological Properties

General Function

Involved in beta-1,4-mannosylglycoprotein 4-beta-N-acet

Specific Function

It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides.

GO Classification

Biological Process
post-translational protein modification
protein N-linked glycosylation via asparagine
Cellular Component
integral to membrane
Golgi membrane
Component
membrane
cell part
Function
transferase activity
beta-1,4-mannosylglycoprotein 4-beta-n-acetylglucosaminyltransferase activity
acetylglucosaminyltransferase activity
udp-glycosyltransferase activity
transferase activity, transferring glycosyl groups
catalytic activity
Molecular Function
beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
Process
metabolic process
macromolecule metabolic process
macromolecule modification
protein modification process
protein amino acid glycosylation
protein amino acid n-linked glycosylation

Cellular Location

Golgi apparatus membrane
Single-pass type II membrane protein

Pathways

Name	SMPDB/Pathwhiz	KEGG
protein glycosylation	Not Available	Not Available
N-Glycan biosynthesis	Not Available

Gene Properties

Chromosome Location

Locus

22q13.1

SNPs

MGAT3

Gene Sequence

>1602 bp
ATGAAGATGAGACGCTACAAGCTCTTTCTCATGTTCTGTATGGCCGGCCTGTGCCTCATC
TCCTTCCTGCACTTCTTCAAGACCCTGTCCTATGTCACCTTCCCCCGAGAACTGGCCTCC
CTCAGCCCTAACCTGGTGTCCAGCTTTTTCTGGAACAATGCCCCGGTCACGCCCCAGGCC
AGCCCCGAGCCAGGAGGCCCTGACCTGCTGCGTACCCCACTCTACTCCCACTCGCCCCTG
CTGCAGCCGCTGCCGCCCAGCAAGGCGGCCGAGGAGCTCCACCGGGTGGACTTGGTGCTG
CCCGAGGACACCACCGAGTATTTCGTGCGCACCAAGGCCGGCGGCGTCTGCTTCAAACCC
GGCACCAAGATGCTGGAGAGGCCGCCCCCGGGACGGCCGGAGGAGAAGCCTGAGGGGGCC
AACGGCTCCTCGGCCCGGCGGCCACCCCGGTACCTCCTGAGCGCCCGGGAGCGCACGGGG
GGCCGAGGCGCCCGGCGCAAGTGGGTGGAGTGCGTGTGCCTGCCCGGCTGGCACGGACCC
AGCTGCGGCGTGCCCACTGTGGTGCAGTACTCCAACCTGCCCACCAAGGAGCGGCTGGTG
CCCAGGGAGGTGCCGCGCCGCGTCATCAACGCCATCAACGTCAACCACGAGTTCGACCTG
CTGGACGTGCGCTTCCACGAGCTGGGCGACGTGGTGGACGCCTTTGTGGTGTGCGAGTCC
AACTTCACGGCTTATGGGGAGCCGCGGCCGCTCAAGTTCCGGGAGATGCTGACCAATGGC
ACCTTCGAGTACATCCGCCACAAGGTGCTCTATGTCTTCCTGGACCACTTCCCGCCCGGC
GGCCGGCAGGACGGCTGGATCGCCGACGACTACCTGCGCACCTTCCTCACCCAGGACGGC
GTCTCGCGGCTGCGCAACCTGCGGCCCGACGACGTCTTCATCATTGACGATGCGGACGAG
ATCCCGGCCCGTGACGGCGTCCTTTTCCTCAAGCTCTACGATGGCTGGACCGAGCCCTTC
GCCTTCCACATGCGCAAGTCGCTCTACGGCTTCTTCTGGAAGCAGCCGGGCACCCTGGAG
GTGGTGTCAGGCTGCACGGTGGACATGCTGCAGGCAGTGTATGGGCTGGACGGCATCCGC
CTGCGCCGCCGCCAGTACTACACCATGCCCAACTTCAGACAGTATGAGAACCGCACCGGC
CACATCCTGGTGCAGTGGTCGCTGGGCAGCCCCCTGCACTTCGCCGGCTGGCACTGCTCC
TGGTGCTTCACGCCCGAGGGCATCTACTTCAAGCTCGTGTCCGCCCAGAATGGCGACTTC
CCACGCTGGGGTGACTACGAGGACAAGCGGGACCTGAACTACATCCGCGGCCTGATCCGC
ACCGGGGGCTGGTTCGACGGCACGCAGCAGGAGTACCCGCCTGCAGACCCCAGCGAGCAC
ATGTATGCGCCCAAGTACCTGCTGAAGAACTACGACCGGTTCCACTACCTGCTGGACAAC
CCCTACCAGGAGCCCAGGAGCACGGCGGCGGGCGGGTGGCGCCACAGGGGTCCCGAGGGA
AGGCCGCCCGCCCGGGGCAAACTGGACGAGGCGGAAGTCTAG

Protein Properties

Number of Residues

533

Molecular Weight

61312.45

Theoretical pI

8.278

Pfam Domain Function

Glyco_transf_17 (PF04724 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
MKMRRYKLFLMFCMAGLCLISFLHFFKTLSYVTFPRELASLSPNLVSSFFWNNAPVTPQA
SPEPGGPDLLRTPLYSHSPLLQPLPPSKAAEELHRVDLVLPEDTTEYFVRTKAGGVCFKP
GTKMLERPPPGRPEEKPEGANGSSARRPPRYLLSARERTGGRGARRKWVECVCLPGWHGP
SCGVPTVVQYSNLPTKERLVPREVPRRVINAINVNHEFDLLDVRFHELGDVVDAFVVCES
NFTAYGEPRPLKFREMLTNGTFEYIRHKVLYVFLDHFPPGGRQDGWIADDYLRTFLTQDG
VSRLRNLRPDDVFIIDDADEIPARDGVLFLKLYDGWTEPFAFHMRKSLYGFFWKQPGTLE
VVSGCTVDMLQAVYGLDGIRLRRRQYYTMPNFRQYENRTGHILVQWSLGSPLHFAGWHCS
WCFTPEGIYFKLVSAQNGDFPRWGDYEDKRDLNYIRGLIRTGGWFDGTQQEYPPADPSEH
MYAPKYLLKNYDRFHYLLDNPYQEPRSTAAGGWRHRGPEGRPPARGKLDEAEV

External Links

GenBank ID Protein

56202888

UniProtKB/Swiss-Prot ID

Q09327

UniProtKB/Swiss-Prot Entry Name

MGAT3_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AL022312

GeneCard ID