| Identification |
|---|
| HMDB Protein ID
| CDBP01555 |
| Secondary Accession Numbers
| Not Available |
| Name
| N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase |
| Description
| Not Available |
| Synonyms
|
- I-beta-1,3-N-acetylglucosaminyltransferase
- Poly-N-acetyllactosamine extension enzyme
- UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
- iGnT
|
| Gene Name
| B3GNT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in N-acetyllactosaminide beta-1,3-N-acetylgluc |
| Specific Function
| Can initiate the synthesis or the elongation of the linear poly-N-acetyllactosaminoglycans.
|
| GO Classification
|
| Biological Process |
| keratan sulfate biosynthetic process |
| poly-N-acetyllactosamine biosynthetic process |
| protein glycosylation |
| Cellular Component |
| integral to Golgi membrane |
| Molecular Function |
| N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity |
|
| Cellular Location
|
- Golgi apparatus membrane
- Single-pass type II membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | protein glycosylation | Not Available | Not Available | | Glycosaminoglycan biosynthesis - keratan sulfate | Not Available |  | | Glycosphingolipid biosynthesis - lacto and neolacto series | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| 11q13.2 |
| SNPs
| B3GNT1 |
| Gene Sequence
|
>1248 bp
ATGCAGATGTCCTACGCCATCCGGTGCGCCTTCTACCAGCTGCTGCTGGCCGCGCTCATG
CTGGTGGCGATGCTGCAGCTGCTCTACCTGTCGCTGCTGTCCGGACTGCACGGGCAGGAG
GAGCAAGACCAATATTTTGAGTTCTTTCCCCCGTCCCCACGGTCCGTGGACCAGGTCAAG
GCGCAGCTCCGCACCGCGCTGGCCTCTGGAGGCGTCCTGGACGCTAGCGGCGATTACCGC
GTCTACAGGGGCCTGCTGAAGACCACCATGGACCCCAACGATGTGATCCTGGCCACGCAC
GCCAGCGTGGACAACCTGCTGCACCTGTCGGGTCTGCTGGAGCGCTGGGAGGGCCCGCTG
TCCGTGTCGGTGTTCGCGGCCACCAAGGAGGAGGCGCAGCTGGCCACGGTGCTGGCCTAC
GCGCTGAGCAGCCACTGCCCCGACATGCGCGCCAGGGTCGCCATGCACCTCGTGTGCCCC
TCGCGTTACGAGGCAGCCGTGCCCGACCCCCGGGAGCCGGGGGAGTTTGCCCTGCTGCGG
TCCTGCCAGGAGGTCTTTGACAAGCTAGCCAGGGTGGCCCAGCCCGGGATTAATTATGCG
CTGGGCACCAATGTCTCCTACCCCAATAACCTGCTGAGGAATCTGGCTCGTGAGGGGGCC
AACTATGCCCTGGTGATCGATGTGGACATGGTGCCCAGCGAGGGGCTGTGGAGAGGCCTG
CGGGAAATGCTGGATCAGAGCAACCAGTGGGGAGGCACCGCGCTGGTGGTGCCTGCCTTC
GAAATCCGAAGAGCCCGCCGCATGCCCATGAACAAAAACGAGCTGGTGCAGCTCTACCAG
GTTGGCGAGGTGCGGCCCTTCTATTATGGGTTGTGCACCCCCTGCCAGGCACCCACCAAC
TATTCCCGCTGGGTCAACCTGCCGGAAGAGAGCTTGCTGCGGCCCGCCTACGTGGTACCT
TGGCAGGACCCCTGGGAGCCATTCTACGTGGCAGGAGGCAAGGTGCCCACCTTCGACGAG
CGCTTTCGGCAGTACGGCTTCAACCGAATCAGCCAGGCCTGCGAGCTGCATGTGGCGGGG
TTTGATTTTGAGGTCCTGAACGAAGGTTTCTTGGTTCATAAGGGCTTCAAAGAAGCGTTG
AAGTTCCATCCCCAAAAGGAGGCTGAAAATCAGCACAATAAGATCCTATATCGCCAGTTC
AAACAGGAGTTGAAGGCCAAGTACCCCAACTCTCCCCGACGCTGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 415 |
| Molecular Weight
| 47118.67 |
| Theoretical pI
| 7.199 |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase
MQMSYAIRCAFYQLLLAALMLVAMLQLLYLSLLSGLHGQEEQDQYFEFFPPSPRSVDQVK
AQLRTALASGGVLDASGDYRVYRGLLKTTMDPNDVILATHASVDNLLHLSGLLERWEGPL
SVSVFAATKEEAQLATVLAYALSSHCPDMRARVAMHLVCPSRYEAAVPDPREPGEFALLR
SCQEVFDKLARVAQPGINYALGTNVSYPNNLLRNLAREGANYALVIDVDMVPSEGLWRGL
REMLDQSNQWGGTALVVPAFEIRRARRMPMNKNELVQLYQVGEVRPFYYGLCTPCQAPTN
YSRWVNLPEESLLRPAYVVPWQDPWEPFYVAGGKVPTFDERFRQYGFNRISQACELHVAG
FDFEVLNEGFLVHKGFKEALKFHPQKEAENQHNKILYRQFKQELKAKYPNSPRRC
|
| External Links |
|---|
| GenBank ID Protein
| 2745741 |
| UniProtKB/Swiss-Prot ID
| O43505 |
| UniProtKB/Swiss-Prot Entry Name
| B3GN1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF029893 |
| GeneCard ID
| B3GNT1 |
| GenAtlas ID
| B3GNT1 |
| HGNC ID
| HGNC:15685 |
| References |
|---|
| General References
| Not Available |