| Identification |
|---|
| HMDB Protein ID
| CDBP01546 |
| Secondary Accession Numbers
| Not Available |
| Name
| Glutaredoxin-1 |
| Description
| Not Available |
| Synonyms
|
- TTase-1
- Thioltransferase-1
|
| Gene Name
| GLRX |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Posttranslational modification, protein turnover, chaperones |
| Specific Function
| Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins |
| GO Classification
|
| Function |
| catalytic activity |
| electron carrier activity |
| oxidoreductase activity, acting on a sulfur group of donors |
| disulfide oxidoreductase activity |
| protein disulfide oxidoreductase activity |
| oxidoreductase activity |
| Process |
| cellular process |
| cellular homeostasis |
| cell redox homeostasis |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q14 |
| SNPs
| GLRX |
| Gene Sequence
|
>321 bp
ATGGCTCAAGAGTTTGTGAACTGCAAAATCCAGCCTGGGAAGGTGGTTGTGTTCATCAAG
CCCACCTGCCCGTACTGCAGGAGGGCCCAAGAGATCCTCAGTCAATTGCCCATCAAACAA
GGGCTTCTGGAATTTGTCGATATCACAGCCACCAACCACACTAACGAGATTCAAGATTAT
TTGCAACAGCTCACGGGAGCAAGAACGGTGCCTCGAGTCTTTATTGGTAAAGATTGTATA
GGCGGATGCAGTGATCTAGTCTCTTTGCAACAGAGTGGGGAACTGCTGACGCGGCTAAAG
CAGATTGGAGCTCTGCAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 106 |
| Molecular Weight
| 11775.7 |
| Theoretical pI
| 8.21 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Glutaredoxin-1
MAQEFVNCKIQPGKVVVFIKPTCPYCRRAQEILSQLPIKQGLLEFVDITATNHTNEIQDY
LQQLTGARTVPRVFIGKDCIGGCSDLVSLQQSGELLTRLKQIGALQ
|
| External Links |
|---|
| GenBank ID Protein
| 3603310 |
| UniProtKB/Swiss-Prot ID
| P35754 |
| UniProtKB/Swiss-Prot Entry Name
| GLRX1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF069668 |
| GeneCard ID
| GLRX |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |