| Identification |
|---|
| HMDB Protein ID
| CDBP01544 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ecto-NOX disulfide-thiol exchanger 2 |
| Description
| Not Available |
| Synonyms
|
- APK1 antigen
- Cytosolic ovarian carcinoma antigen 1
- Hydroquinone [NADH] oxidase
- Protein disulfide-thiol oxidoreductase
- Tumor-associated hydroquinone oxidase
- tNOX
|
| Gene Name
| ENOX2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in nucleotide binding |
| Specific Function
| May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide- thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock |
| GO Classification
|
| Function |
| binding |
| nucleotide binding |
| nucleic acid binding |
|
| Cellular Location
|
- Cell membrane
- Secreted
- extracellular space
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| ENOX2 |
| Gene Sequence
|
>1833 bp
ATGCAAAGAGATTTTAGATGGCTGTGGGTCTACGAAATAGGCTATGCAGCCGATAACAGT
AGAACTCTGAACGTGGATTCCACTGCAATGACACTACCTATGTCTGATCCAACTGCATGG
GCCACAGCAATGAATAATCTTGGAATGGCACCGCTGGGAATTGCCGGACAACCAATTTTA
CCTGACTTTGATCCTGCTCTTGGAATGATGACTGGAATTCCACCAATAACTCCAATGATG
CCTGGTTTGGGAATAGTACCTCCACCAATTCCTCCAGATATGCCAGTAGTAAAAGAGATC
ATACACTGTAAAAGCTGCACGCTCTTCCCTCCAAATCCAAATCTCCCACCTCCTGCAACC
CGAGAAAGACCACCAGGATGCAAAACAGTATTTGTGGGTGGTCTGCCTGAAAATGGGACA
GAGCAAATCATTGTGGAAGTTTTCGAGCAGTGTGGAGAGATCATTGCCATTCGCAAGAGC
AAGAAGAACTTCTGCCACATTCGCTTTGCTGAGGAGTACATGGTGGACAAAGCCCTGTAT
CTGTCTGGTTACCGCATTCGCCTGGGCTCTAGTACTGACAAGAAGGACACAGGCAGACTC
CACGTTGATTTCGCACAGGCTCGAGATGACCTGTATGAGTGGGAGTGTAAACAGCGTATG
CTAGCCAGAGAGGAGCGCCATCGTAGAAGAATGGAAGAAGAAAGATTGCGTCCACCATCT
CCACCCCCAGTGGTCCACTATTCAGATCATGAATGCAGCATTGTTGCTGAAAAATTAAAA
GATGATTCCAAATTCTCAGAAGCTGTACAGACCTTGCTTACCTGGATAGAGCGAGGAGAG
GTCAACCGTCGTAGCGCCAATAACTTCTACTCCATGATCCAGTCGGCCAACAGCCATGTC
CGCCGCCTGGTGAACGAGAAAGCTGCCCATGAGAAAGATATGGAAGAAGCAAAGGAGAAG
TTCAAGCAGGCCCTTTCTGGAATTCTCATTCAATTTGAGCAGATAGTGGCTGTGTACCAT
TCCGCCTCCAAGCAGAAGGCATGGGACCACTTCACAAAAGCCCAGCGGAAGAACATCAGC
GTGTGGTGCAAACAAGCTGAGGAAATTCGCAACATTCATAATGATGAATTAATGGGAATC
AGGCGAGAAGAAGAAATGGAAATGTCTGATGATGAAATAGAAGAAATGACAGAAACAAAA
GAAACTGAGGAATCAGCCTTAGTATCACAGGCAGAAGCTCTGAAGGAAGAAAATGACAGC
CTCCGTTGGCAGCTCGATGCCTACCGGAATGAAGTAGAACTGCTCAAGCAAGAACAAGGC
AAAGTCCACAGAGAAGATGACCCTAACAAAGAACAGCAGCTGAAACTCCTGCAACAAGCC
CTGCAAGGAATGCAACAGCATCTACTCAAAGTCCAAGAGGAATACAAAAAGAAAGAAGCT
GAACTTGAAAAACTCAAAGATGACAAGTTACAGGTGGAAAAAATGTTGGAAAATCTTAAA
GAAAAGGAAAGCTGTGCTTCTAGGCTGTGTGCCTCAAACCAGGATAGCGAATACCCTCTT
GAGAAGACCATGAACAGCAGTCCTATCAAATCTGAACGTGAAGCACTGCTAGTGGGGATT
ATCTCCACATTCCTTCATGTTCACCCATTTGGAGCAAGCATTGAATACATCTGTTCCTAC
TTGCACCGTCTTGATAATAAGATCTGCACCAGCGATGTGGAGTGTCTCATGGGTAGACTC
CAGCATACCTTCAAGCAGGAAATGACTGGAGTTGGAGCCAGCCTGGAAAAGAGATGGAAA
TTCTGTGGCTTCGAGGGCTTGAAGCTGACCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 610 |
| Molecular Weight
| 70081.5 |
| Theoretical pI
| 5.78 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ecto-NOX disulfide-thiol exchanger 2
MQRDFRWLWVYEIGYAADNSRTLNVDSTAMTLPMSDPTAWATAMNNLGMAPLGIAGQPIL
PDFDPALGMMTGIPPITPMMPGLGIVPPPIPPDMPVVKEIIHCKSCTLFPPNPNLPPPAT
RERPPGCKTVFVGGLPENGTEQIIVEVFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALY
LSGYRIRLGSSTDKKDTGRLHVDFAQARDDLYEWECKQRMLAREERHRRRMEEERLRPPS
PPPVVHYSDHECSIVAEKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHV
RRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNIS
VWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDS
LRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEA
ELEKLKDDKLQVEKMLENLKEKESCASRLCASNQDSEYPLEKTMNSSPIKSEREALLVGI
ISTFLHVHPFGASIEYICSYLHRLDNKICTSDVECLMGRLQHTFKQEMTGVGASLEKRWK
FCGFEGLKLT
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q16206 |
| UniProtKB/Swiss-Prot Entry Name
| ENOX2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF207881 |
| GeneCard ID
| ENOX2 |
| GenAtlas ID
| ENOX2 |
| HGNC ID
| HGNC:2259 |
| References |
|---|
| General References
| Not Available |