| Identification |
|---|
| HMDB Protein ID
| CDBP01467 |
| Secondary Accession Numbers
| Not Available |
| Name
| 1-acyl-sn-glycerol-3-phosphate acyltransferase beta |
| Description
| Not Available |
| Synonyms
|
- 1-AGP acyltransferase 2
- 1-AGPAT 2
- 1-acylglycerol-3-phosphate O-acyltransferase 2
- LPAAT-beta
- Lysophosphatidic acid acyltransferase beta
|
| Gene Name
| AGPAT2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
|
| GO Classification
|
| Biological Process |
| small molecule metabolic process |
| CDP-diacylglycerol biosynthetic process |
| positive regulation of cytokine production |
| positive regulation of cytokine-mediated signaling pathway |
| phosphatidic acid biosynthetic process |
| triglyceride biosynthetic process |
| epidermis development |
| Cellular Component |
| endoplasmic reticulum membrane |
| integral to membrane |
| Component |
| membrane |
| cell part |
| Function |
| transferase activity |
| transferase activity, transferring acyl groups |
| transferase activity, transferring acyl groups other than amino-acyl groups |
| acyltransferase activity |
| acylglycerol o-acyltransferase activity |
| 1-acylglycerol-3-phosphate o-acyltransferase activity |
| o-acyltransferase activity |
| catalytic activity |
| Molecular Function |
| 1-acylglycerol-3-phosphate O-acyltransferase activity |
| Process |
| metabolic process |
| phospholipid biosynthetic process |
| organophosphate metabolic process |
| phospholipid metabolic process |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein (Potential)
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | CDP-diacylglycerol biosynthesis | Not Available | Not Available | | Glycerophospholipid metabolism | Not Available |  | | Fat digestion and absorption | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 9 |
| Locus
| 9q34.3 |
| SNPs
| AGPAT2 |
| Gene Sequence
|
>837 bp
ATGGAGCTGTGGCCGTGTCTGGCCGCGGCGCTGCTGTTGCTGCTGCTGCTGGTGCAGCTG
AGCCGCGCGGCCGAGTTCTACGCCAAGGTCGCCCTGTACTGCGCGCTGTGCTTCACGGTG
TCCGCCGTGGCCTCGCTCGTCTGCCTGCTGCGCCACGGCGGCCGGACGGTGGAGAACATG
AGCATCATCGGCTGGTTCGTGCGAAGCTTCAAGTACTTTTACGGGCTCCGCTTCGAGGTG
CGGGACCCGCGCAGGCTGCAGGAGGCCCGTCCCTGTGTCATCGTCTCCAACCACCAGAGC
ATCCTGGACATGATGGGCCTCATGGAGGTCCTTCCGGAGCGCTGCGTGCAGATCGCCAAG
CGGGAGCTGCTCTTCCTGGGGCCCGTGGGCCTCATCATGTACCTCGGGGGCGTCTTCTTC
ATCAACCGGCAGCGCTCTAGCACTGCCATGACAGTGATGGCCGACCTGGGCGAGCGCATG
GTCAGGGAGAACCTCAAAGTGTGGATCTATCCCGAGGGTACTCGCAACGACAATGGGGAC
CTGCTGCCTTTTAAGAAGGGCGCCTTCTACCTGGCAGTCCAGGCACAGGTGCCCATCGTC
CCCGTGGTGTACTCTTCCTTCTCCTCCTTCTACAACACCAAGAAGAAGTTCTTCACTTCA
GGAACAGTCACAGTGCAGGTGCTGGAAGCCATCCCCACCAGCGGCCTCACTGCGGCGGAC
GTCCCTGCGCTCGTGGACACCTGCCACCGGGCCATGAGGACCACCTTCCTCCACATCTCC
AAGACCCCCCAGGAGAACGGGGCCACTGCGGGGTCTGGCGTGCAGCCGGCCCAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 278 |
| Molecular Weight
| 27278.915 |
| Theoretical pI
| 8.913 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>1-acyl-sn-glycerol-3-phosphate acyltransferase beta
MELWPCLAAALLLLLLLVQLSRAAEFYAKVALYCALCFTVSAVASLVCLLRHGGRTVENM
SIIGWFVRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCVQIAK
RELLFLGPVGLIMYLGGVFFINRQRSSTAMTVMADLGERMVRENLKVWIYPEGTRNDNGD
LLPFKKGAFYLAVQAQVPIVPVVYSSFSSFYNTKKKFFTSGTVTVQVLEAIPTSGLTAAD
VPALVDTCHRAMRTTFLHISKTPQENGATAGSGVQPAQ
|
| External Links |
|---|
| GenBank ID Protein
| 2282590 |
| UniProtKB/Swiss-Prot ID
| O15120 |
| UniProtKB/Swiss-Prot Entry Name
| PLCB_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF000237 |
| GeneCard ID
| AGPAT2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| HGNC:325 |
| References |
|---|
| General References
| Not Available |