Cannabis Compound Database: Showing Protein Synaptojanin-2 (CDBP01459)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP01459

Secondary Accession Numbers

Not Available

Name

Synaptojanin-2

Description

Not Available

Synonyms

Synaptic inositol-1,4,5-trisphosphate 5-phosphatase 2
Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2

Gene Name

SYNJ2

Protein Type

Enzyme

Biological Properties

General Function

Involved in nucleotide binding

Specific Function

Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.

GO Classification

Biological Process
small molecule metabolic process
phosphatidylinositol biosynthetic process
phosphatidylinositol dephosphorylation
inositol phosphate dephosphorylation
phosphatidylinositol phosphorylation
brain development
intracellular distribution of mitochondria
Cellular Component
cytosol
perinuclear region of cytoplasm
axon terminus
ruffle membrane
cytoplasmic microtubule
extrinsic to mitochondrial outer membrane
Function
rna binding
hydrolase activity, acting on ester bonds
binding
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
inositol or phosphatidylinositol phosphatase activity
nucleic acid binding
phosphatidylinositol bisphosphate phosphatase activity
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
Molecular Function
inositol-polyphosphate 5-phosphatase activity
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
RNA binding
nucleotide binding
Process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
metabolic process
cellular metabolic process

Cellular Location

Membrane

Pathways

Name	SMPDB/Pathwhiz	KEGG
Phosphatidylinositol signaling system	Not Available

Gene Properties

Chromosome Location

Locus

6q25.3

SNPs

SYNJ2

Gene Sequence

>4491 bp
ATGGCCCTGAGCAAAGGGCTGCGGCTGCTGGGGCGCCTGGGGGCCGAGGGGGACTGTAGC
GTGCTGCTGGAGGCGCGCGGCCGCGACGACTGCCTGCTGTTCGAGGCCGGCACGGTGGCC
ACGCTGGCTCCAGAAGAAAAGGAAGTCATTAAAGGACAGTATGGCAAGCTCACGGACGCG
TACGGCTGCCTGGGGGAGCTGAGGCTGAAATCTGGTGGCACGTCTCTGAGCTTCCTGGTG
TTGGTGACAGGCTGCACATCTGTGGGCAGAATTCCAGATGCTGAAATCTACAAAATCACT
GCCACTGACTTTTACCCTCTTCAGGAAGAGGCCAAGGAGGAGGAACGCCTCATAGCTTTG
AAGAAAATCCTCAGCTCGGGGGTGTTCTATTTCTCATGGCCAAACGATGGGTCTCGCTTT
GACCTGACTGTCCGCACGCAGAAGCAGGGGGATGACAGCTCTGAATGGGGGAACTCCTTC
TTCTGGAACCAGCTGTTGCACGTGCCCTTGAGGCAGCACCAGGTGAGCTGCTGTGACTGG
CTGCTGAAGATCATCTGCGGGGTGGTCACCATCCGCACCGTGTATGCCTCCCACAAGCAG
GCCAAGGCCTGCCTCGTCTCTCGCGTTAGCTGTGAGCGCACAGGCACTCGCTTCCACACC
CGTGGCGTGAACGACGACGGCCATGTGTCCAACTTCGTGGAGACAGAGCAGATGATTTAC
ATGGACGATGGAGTGTCATCTTTTGTCCAGATCAGAGGCTCCGTTCCGCTGTTCTGGGAA
CAGCCAGGGCTTCAGGTTGGCTCCCATCATCTGAGACTCCACAGAGGCCTGGAAGCCAAT
GCCCCTGCTTTCGACAGGCACATGGTGCTTCTGAAGGAGCAGTACGGGCAGCAGGTGGTC
GTGAACCTTCTGGGAAGCAGAGGCGGAGAGGAGGTGCTCAACAGAGCCTTCAAGAAGCTG
CTCTGGGCTTCTTGCCACGCGGGCGACACGCCTATGATCAATTTTGACTTCCATCAGTTT
GCCAAAGGTGGGAAGCTAGAGAAATTGGAGACCCTCTTGAGGCCACAGTTAAAGCTGCAC
TGGGAAGACTTCGATGTGTTCACAAAGGGGGAGAACGTCAGTCCACGTTTTCAGAAAGGC
ACTTTGCGGATGAACTGTCTTGACTGCCTGGACCGAACCAACACTGTGCAGAGCTTCATC
GCGCTCGAGGTCCTGCATCTGCAGCTCAAGACCCTGGGGCTGAGTTCAAAACCCATCGTT
GACCGCTTTGTGGAGTCCTTCAAAGCCATGTGGTCTCTGAATGGCCACAGCCTGAGCAAG
GTGTTCACAGGCAGCAGAGCCCTGGAAGGGAAGGCCAAGGTGGGGAAGCTGAAGGATGGA
GCCCGGTCCATGTCTCGAACCATCCAGTCCAACTTCTTCGACGGGGTGAAGCAGGAGGCC
ATCAAGCTGCTGCTGGTTGGGGACGTCTACGGCGAGGAGGTGGCAGACAAAGGGGGCATG
CTGCTGGACAGCACGGCGCTCCTGGTGACTCCCAGGATCCTGAAAGCTATGACTGAGCGT
CAGTCCGAATTCACAAATTTCAAGCGGATCCGGATTGCTATGGGGACCTGGAACGTGAAC
GGAGGAAAGCAGTTCCGGAGCAACGTGCTCAGGACGGCGGAGCTGACAGACTGGCTGCTC
GACTCGCCCCAGCTCTCGGGAGCTACCGACTCCCAGGATGACAGCAGCCCAGCTGACATA
TTTGCTGTGGGGTTTGAAGAGATGGTGGAATTGAGCGCAGGGAATATTGTCAATGCCAGT
ACTACCAACAAGAAGATGTGGGGTGAACAGCTTCAGAAAGCCATCTCACGCTCTCATAGA
TACATTCTGTTGACTTCGGCACAGCTGGTGGGCGTCTGTCTTTATATCTTTGTACGTCCA
TACCATGTCCCGTTCATCAGGGACGTAGCCATCGACACAGTGAAGACGGGCATGGGGGGC
AAGGCGGGGAACAAGGGCGCCGTCGGCATCCGCTTCCAGTTCCACAGCACCAGCTTCTGC
TTCATATGTAGTCACCTGACGGCCGGGCAGTCCCAGGTGAAGGAGCGGAATGAAGACTAC
AAGGAGATCACCCAGAAACTCTGCTTCCCAATGGGGAGAAATGTTTTTTCTCATGATTAT
GTATTTTGGTGTGGCGATTTCAACTACCGCATTGATCTTACTTATGAAGAAGTCTTCTAT
TTTGTTAAACGCCAAGACTGGAAGAAACTTCTGGAATTTGATCAACTACAGCTACAGAAA
TCAAGTGGAAAAATTTTTAAGGACTTTCACGAAGGAGCCATTAACTTTGGACCCACCTAC
AAGTATGACGTTGGCTCAGCCGCCTACGATACAAGCGACAAATGCCGCACCCCCGCCTGG
ACAGACAGGGTGCTGTGGTGGAGGAAGAAACATCCCTTTGATAAAACAGCTGGAGAACTC
AACCTTCTAGACAGTGATCTAGATGTTGACACCAAAGTCAGACACACCTGGTCTCCTGGT
GCCCTGCAGTATTATGGTCGTGCGGAGCTACAAGCGTCTGATCACAGACCTGTGCTGGCG
ATCGTGGAGGTGGAAGTTCAGGAAGTCGATGTGGGTGCTCGGGAGAGGGTTTTCCAGGAA
GTGTCCTCCTTCCAGGGCCCCCTGGATGCCACTGTTGTAGTAAACCTTCAATCACCGACC
TTAGAAGAGAAAAACGAGTTTCCAGAGGACCTGCGTACTGAGCTCATGCAGACCTTGGGG
AGTTATGGGACAATTGTTCTTGTCAGGATCAACCAAGGGCAGATGCTGGTAACTTTTGCA
GACAGTCACTCGGCTCTCAGTGTCCTGGACGTGGACGGTATGAAGGTGAAAGGCAGAGCA
GTGAAGATTAGACCGAAGACCAAGGACTGGCTGAAAGGTTTGCGAGAGGAGATCATTCGG
AAACGAGACAGCATGGCCCCCGTGTCTCCCACTGCCAACTCCTGTTTGCTGGAGGAAAAC
TTTGACTTCACAAGTTTGGACTATGAGTCAGAAGGGGATATTCTTGAAGACGATGAAGAC
TACTTGGTGGATGAATTCAATCAGCCTGGAGTCTCGGACAGTGAACTCGGGGGAGACGAC
CTCTCTGATGTCCCCGGCCCCACAGCACTGGCTCCTCCCAGCAAGTCACCTGCTCTCACC
AAAAAGAAGCAGCATCCAACGTACAAAGATGACGCGGACCTGGTGGAGCTCAAGCGGGAG
CTGGAAGCCGTCGGGGAGTTCCGCCACCGTTCTCCGAGCAGGTCTCTGTCGGTCCCCAAC
CGGCCTCGGCCACCTCAACCCCCGCAGAGACCCCCCCCTCCAACCGGTTTAATGGTGAAA
AAGTCGGCTTCAGATGCGTCCATCTCCTCCGGCACCCATGGACAGTATTCAATTTTGCAG
ACGGCAAGACTTCTACCAGGAGCACCTCAGCAACCTCCCAAGGCTCGGACTGGAATAAGT
AAACCTTATAATGTCAAGCAGATCAAAACCACCAATGCCCAGGAGGCAGAAGCAGCAATC
CGGTGTCTCCTGGAAGCCAGAGGAGGTGCCTCCGAAGAAGCCCTAAGTGCCGTGGCCCCA
AGGGACCTTGAAGCATCCTCTGAACCAGAGCCCACACCGGGGGCAGCCAAACCAGAGACC
CCACAGGCGCCCCCACTCCTTCCCCGTCGGCCCCCACCCAGAGTTCCTGCCATCAAGAAG
CCAACCTTGAGAAGGACAGGAAAGCCCCTGTCACCGGAAGAACAGTTTGAGCAACAGACT
GTCCATTTTACAATCGGGCCCCCGGAGACAAGCGTTGAGGCCCCTCCTGTCGTGACAGCC
CCTCGAGTCCCTCCTGTTCCCAAACCAAGAACATTTCAGCCTGGGAAAGCTGCAGAGAGG
CCAAGCCACAGGAAGCCAGCATCAGACGAAGCCCCTCCTGGGGCAGGAGCCTCTGTGCCA
CCACCTCTGGAGGCGCCGCCTCTTGTGCCCAAGGTACCCCCGAGGAGGAAGAAGTCAGCC
CCCGCAGCCTTCCACCTGCAGGTCCTGCAGAGCAACAGCCAGCTTCTCCAGGGCCTCACT
TACAATAGCAGTGACAGCCCCTCTGGGCACCCACCTGCCGCGGGCACCGTCTTCCCACAA
GGGGACTTTCTCAGCACTTCATCTGCTACAAGCCCCGACAGCGATGGCACCAAAGCGATG
AAGCCAGAGGCAGCCCCACTTCTTGGTGATTATCAGGACCCCTTCTGGAACCTTCTTCAC
CACCCTAAACTGTTGAATAACACTTGGCTTTCTAAGAGCTCAGACCCTTTGGACTCAGGA
ACCAGGAGCCCCAAAAGAGATCCCATAGACCCAGTGTCAGCTGGCGCTTCAGCTGCCAAG
GCAGAGCTGCCACCAGATCATGAACACAAAACCTTAGGTCACTGGGTGACAATCAGTGAC
CAAGAAAAGAGGACAGCACTGCAGGTGTTTGACCCACTGGCAAAAACATGA

Protein Properties

Number of Residues

1496

Molecular Weight

165536.575

Theoretical pI

7.341

Pfam Domain Function

Exo_endo_phos (PF03372 )
DUF1866 (PF08952 )
Syja_N (PF02383 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Synaptojanin-2
MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDA
YGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIAL
KKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDW
LLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY
MDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVV
VNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLH
WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKPIV
DRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEA
IKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVN
GGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSAGNIVNAS
TTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGG
KAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGRNVFSHDY
VFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTY
KYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPG
ALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPT
LEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRA
VKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDDED
YLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRE
LEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQ
TARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAP
RDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQT
VHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVP
PPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQ
GDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSG
TRSPKRDPIDPVSAGASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPLAKT

External Links

GenBank ID Protein

26190608

UniProtKB/Swiss-Prot ID

O15056

UniProtKB/Swiss-Prot Entry Name

SYNJ2_HUMAN

PDB IDs