Cannabis Compound Database: Showing Protein Beta,beta-carotene 15,15'-monooxygenase (CDBP01456)

Identification Biological properties Gene properties Protein properties External links References XML Show 4 compounds

Identification

HMDB Protein ID

CDBP01456

Secondary Accession Numbers

Not Available

Name

Beta,beta-carotene 15,15'-monooxygenase

Description

Not Available

Synonyms

Beta-carotene dioxygenase 1

Gene Name

BCMO1

Protein Type

Enzyme

Biological Properties

General Function

Secondary metabolites biosynthesis, transport and catabolism

Specific Function

Symmetrically cleaves beta-carotene into two molecules of retinal. The reaction proceeds in three stages, epoxidation of the 15,15'-double bond, hydration of the double bond leading to ring opening, and oxidative cleavage of the diol formed.

GO Classification

Biological Process
retinol metabolic process
vitamin A biosynthetic process
steroid metabolic process
retinal metabolic process
Cellular Component
cytosol
Molecular Function
monooxygenase activity
metal ion binding
beta-carotene 15,15'-monooxygenase activity

Cellular Location

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
Retinol Metabolism
Vitamin A Deficiency		Not Available

Gene Properties

Chromosome Location

Locus

16q23.2

SNPs

BCMO1

Gene Sequence

>1644 bp
ATGGATATAATATTTGGCAGGAATAGGAAAGAACAGCTGGAGCCTGTGAGGGCCAAAGTG
ACAGGCAAGATTCCAGCATGGCTGCAGGGAACCCTGCTCCGCAACGGGCCTGGGATGCAC
ACAGTTGGGGAGTCCAGATACAACCATTGGTTCGACGGCCTTGCCCTGCTCCACAGCTTC
ACCATCAGAGACGGTGAAGTCTATTACAGGAGCAAATACCTGAGAAGCGATACCTACAAC
ACCAATATTGAGGCAAACAGGATTGTGGTGTCTGAGTTTGGAACAATGGCCTATCCGGAC
CCCTGCAAAAACATATTTTCCAAAGCTTTCTCCTACTTGTCTCACACCATCCCCGATTTC
ACCGACAACTGCCTGATCAACATCATGAAGTGCGGAGAAGACTTCTACGCGACCTCAGAG
ACCAATTACATCAGGAAAATCAACCCACAGACTCTGGAAACCCTGGAGAAGGTTGATTAT
CGTAAATACGTGGCGGTAAATCTGGCAACGTCACATCCCCATTATGATGAGGCTGGAAAT
GTTCTAAACATGGGCACATCCATTGTGGAAAAGGGGAAGACAAAGTATGTGATTTTTAAG
ATCCCTGCCACAGTACCAGAGGGCAAGAAGCAGGGGAAGAGCCCCTGGAAGCACACAGAG
GTGTTCTGCTCCATCCCATCCCGCTCCCTGCTCTCCCCAAGCTACTACCACAGCTTTGGA
GTCACCGAGAACTATGTCATCTTCCTTGAGCAGCCTTTCAGGTTGGATATTCTCAAGATG
GCAACCGCATACATCCGGAGAATGAGCTGGGCCTCCTGCCTGGCTTTCCACAGGGAGGAG
AAGACTTATATCCACATCATCGACCAAAGGACCAGGCAGCCTGTGCAGACCAAGTTTTAC
ACAGACGCCATGGTGGTCTTCCATCACGTCAACGCCTACGAAGAGGACGGCTGCATCGTG
TTTGACGTCATTGCCTACGAGGACAACAGCCTCTACCAGCTCTTCTACCTGGCCAACCTG
AACCAGGACTTCAAGGAGAACTCCAGGCTCACCTCGGTCCCCACCCTCAGGAGGTTTGCC
GTGCCCCTCCACGTGGACAAGAATGCAGAAGTGGGCACAAATTTAATCAAAGTGGCATCT
ACAACAGCCACGGCCCTGAAGGAAGAAGATGGCCAAGTCTACTGCCAGCCGGAATTTCTT
TATGAAGGCTTAGAGCTTCCACGGGTCAATTATGCTCACAATGGAAAGCAATACCGATAT
GTCTTTGCTACAGGAGTTCAGTGGAGTCCAATCCCAACCAAGATAATAAAATATGACATT
CTCACAAAGTCATCCTTAAAATGGAGAGAGGACGACTGCTGGCCAGCGGAACCCCTGTTT
GTGCCCGCGCCAGGTGCCAAGGATGAGGATGACGGAGTAATCTTATCAGCCATTGTCTCT
ACTGATCCCCAAAAGCTGCCTTTTCTGCTCATTCTGGATGCCAAAAGCTTTACGGAATTG
GCCCGTGCCTCTGTTGATGTCGATATGCACATGGATCTCCATGGATTATTCATTACAGAC
ATGGACTGGGACACAAAAAAGCAGGCCGCTTCTGAGGAACAGCGGGACAGGGCTTCCGAC
TGCCACGGGGCTCCTCTGACCTGA

Protein Properties

Number of Residues

547

Molecular Weight

62636.69

Theoretical pI

6.672

Pfam Domain Function

RPE65 (PF03055 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Beta,beta-carotene 15,15'-monooxygenase
MDIIFGRNRKEQLEPVRAKVTGKIPAWLQGTLLRNGPGMHTVGESRYNHWFDGLALLHSF
TIRDGEVYYRSKYLRSDTYNTNIEANRIVVSEFGTMAYPDPCKNIFSKAFSYLSHTIPDF
TDNCLINIMKCGEDFYATSETNYIRKINPQTLETLEKVDYRKYVAVNLATSHPHYDEAGN
VLNMGTSIVEKGKTKYVIFKIPATVPEGKKQGKSPWKHTEVFCSIPSRSLLSPSYYHSFG
VTENYVIFLEQPFRLDILKMATAYIRRMSWASCLAFHREEKTYIHIIDQRTRQPVQTKFY
TDAMVVFHHVNAYEEDGCIVFDVIAYEDNSLYQLFYLANLNQDFKENSRLTSVPTLRRFA
VPLHVDKNAEVGTNLIKVASTTATALKEEDGQVYCQPEFLYEGLELPRVNYAHNGKQYRY
VFATGVQWSPIPTKIIKYDILTKSSLKWREDDCWPAEPLFVPAPGAKDEDDGVILSAIVS
TDPQKLPFLLILDAKSFTELARASVDVDMHMDLHGLFITDMDWDTKKQAASEEQRDRASD
CHGAPLT

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

Q9HAY6

UniProtKB/Swiss-Prot Entry Name

BCDO1_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF294900

GeneCard ID