| Identification |
|---|
| HMDB Protein ID
| CDBP01449 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cytochrome P450 19A1 |
| Description
| Not Available |
| Synonyms
|
- Aromatase
- CYPXIX
- Cytochrome P-450AROM
- Estrogen synthase
|
| Gene Name
| CYP19A1 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in monooxygenase activity |
| Specific Function
| Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
|
| GO Classification
|
| Biological Process |
| hippocampus development |
| progesterone metabolic process |
| phthalate metabolic process |
| male gonad development |
| adrenal gland development |
| androgen metabolic process |
| response to ionizing radiation |
| bone development |
| cellular response to hydrostatic pressure |
| response to estradiol stimulus |
| response to herbicide |
| granulocyte differentiation |
| response to morphine |
| hypothalamus development |
| estrogen biosynthetic process |
| melatonin metabolic process |
| prostate gland growth |
| regulation of synapse structure and activity |
| response to cesium ion |
| small molecule metabolic process |
| response to testosterone stimulus |
| biphenyl metabolic process |
| cellular response to glucose stimulus |
| cellular response to fibroblast growth factor stimulus |
| response to drug |
| cellular response to follicle-stimulating hormone stimulus |
| xenobiotic metabolic process |
| dibenzo-p-dioxin metabolic process |
| bile acid metabolic process |
| Cellular Component |
| endoplasmic reticulum membrane |
| cytosol |
| synaptic vesicle |
| terminal button |
| dendritic spine |
| neuronal cell body |
| Function |
| metal ion binding |
| binding |
| catalytic activity |
| transition metal ion binding |
| electron carrier activity |
| iron ion binding |
| monooxygenase activity |
| heme binding |
| oxidoreductase activity |
| ion binding |
| cation binding |
| Molecular Function |
| electron carrier activity |
| oxygen binding |
| aromatase activity |
| iron ion binding |
| heme binding |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Peripheral membrane protein
- Membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Steroid hormone biosynthesis | Not Available |  | | Androgen and Estrogen Metabolism |    |  | | 17-Beta Hydroxysteroid Dehydrogenase III Deficiency |    | Not Available | | Aromatase deficiency |    | Not Available | | Androstenedione Metabolism |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 15 |
| Locus
| 15q21.1 |
| SNPs
| CYP19A1 |
| Gene Sequence
|
>1512 bp
ATGGTTTTGGAAATGCTGAACCCGATACATTATAACATCACCAGCATCGTGCCTGAAGCC
ATGCCTGCTGCCACCATGCCAGTCCTGCTCCTCACTGGCCTTTTTCTCTTGGTGTGGAAT
TATGAGGGCACATCCTCAATACCAGGTCCTGGCTACTGCATGGGAATTGGACCCCTCATC
TCCCACGGCAGATTCCTGTGGATGGGGATCGGCAGTGCCTGCAACTACTACAACCGGGTA
TATGGAGAATTCATGCGAGTCTGGATCTCTGGAGAGGAAACACTCATTATCAGCAAGTCC
TCAAGTATGTTCCACATAATGAAGCACAATCATTACAGCTCTCGATTCGGCAGCAAACTT
GGGCTGCAGTGCATCGGTATGCATGAGAAAGGCATCATATTTAACAACAATCCAGAGCTC
TGGAAAACAACTCGACCCTTCTTTATGAAAGCTCTGTCAGGCCCCGGCCTTGTTCGTATG
GTCACAGTCTGTGCTGAATCCCTCAAAACACATCTGGACAGGTTGGAGGAGGTGACCAAT
GAATCGGGCTATGTGGACGTGTTGACCCTTCTGCGTCGTGTCATGCTGGACACCTCTAAC
ACGCTCTTCTTGAGGATCCCTTTGGACGAAAGTGCTATCGTGGTTAAAATCCAAGGTTAT
TTTGATGCATGGCAAGCTCTCCTCATCAAACCAGACATCTTCTTTAAGATTTCTTGGCTA
TACAAAAAGTATGAGAAGTCTGTCAAGGATTTGAAAGATGCCATAGAAGTTCTGATAGCA
GAAAAAAGACGCAGGATTTCCACAGAAGAGAAACTGGAAGAATGTATGGACTTTGCCACT
GAGTTGATTTTAGCAGAGAAACGTGGTGACCTGACAAGAGAGAATGTGAACCAGTGCATA
TTGGAAATGCTGATCGCAGCTCCTGACACCATGTCTGTCTCTTTGTTCTTCATGCTATTT
CTCATTGCAAAGCACCCTAATGTTGAAGAGGCAATAATAAAGGAAATCCAGACTGTTATT
GGTGAGAGAGACATAAAGATTGATGATATACAAAAATTAAAAGTGATGGAAAACTTCATT
TATGAGAGCATGCGGTACCAGCCTGTCGTGGACTTGGTCATGCGCAAAGCCTTAGAAGAT
GATGTAATCGATGGCTACCCAGTGAAAAAGGGGACAAACATTATCCTGAATATTGGAAGG
ATGCACAGACTCGAGTTTTTCCCCAAACCCAATGAATTTACTCTTGAAAATTTTGCAAAG
AATGTTCCTTATAGGTACTTTCAGCCATTTGGCTTTGGGCCCCGTGGCTGTGCAGGAAAG
TACATCGCCATGGTGATGATGAAAGCCATCCTCGTTACACTTCTGAGACGATTCCACGTG
AAGACATTGCAAGGACAGTGTGTTGAGAGCATACAGAAGATACACGACTTGTCCTTGCAC
CCAGATGAGACTAAAAACATGCTGGAAATGATCTTTACCCCAAGAAACTCAGACAGGTGT
CTGGAACACTAG
|
| Protein Properties |
|---|
| Number of Residues
| 503 |
| Molecular Weight
| 57882.48 |
| Theoretical pI
| 7.502 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Cytochrome P450 19A1
MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI
SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL
GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN
ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL
YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI
LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI
YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK
NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH
PDETKNMLEMIFTPRNSDRCLEH
|
| External Links |
|---|
| GenBank ID Protein
| 61354153 |
| UniProtKB/Swiss-Prot ID
| P11511 |
| UniProtKB/Swiss-Prot Entry Name
| CP19A_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AY957953 |
| GeneCard ID
| CYP19A1 |
| GenAtlas ID
| CYP19A1 |
| HGNC ID
| HGNC:2594 |
| References |
|---|
| General References
| Not Available |