| Identification |
|---|
| HMDB Protein ID
| CDBP01390 |
| Secondary Accession Numbers
| Not Available |
| Name
| Tyrosine-protein kinase STYK1 |
| Description
| Not Available |
| Synonyms
|
- Novel oncogene with kinase domain
- Protein PK-unique
- Serine/threonine/tyrosine kinase 1
|
| Gene Name
| STYK1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein kinase activity |
| Specific Function
| Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| protein binding |
| protein kinase activity |
| protein tyrosine kinase activity |
| binding |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| nucleoside binding |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| metabolic process |
| cellular metabolic process |
| protein amino acid phosphorylation |
| phosphorylation |
|
| Cellular Location
|
- Membrane
- Single-pass membrane protein (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12p13.2 |
| SNPs
| STYK1 |
| Gene Sequence
|
>1269 bp
ATGGGCATGACACGGATGCTCCTGGAATGCAGTCTCAGTGACAAGTTGTGTGTCATCCAG
GAGAAGCAGTATGAAGTGATTATCGTCCCAACTTTGTTGGTTACTATCTTCCTCATCCTT
CTTGGGGTCATCCTGTGGCTTTTTATCAGAGAACAAAGAACTCAACAGCAGCGTTCTGGA
CCTCAAGGCATTGCCCCTGTTCCTCCACCTAGGGACCTAAGCTGGGAAGCAGGACATGGA
GGAAATGTGGCTTTGCCACTTAAGGAGACATCCGTGGAAAACTTTCTGGGAGCTACCACA
CCTGCCCTGGCTAAGCTGCAGGTGCCGCGGGAGCAACTCTCTGAAGTTCTGGAGCAGATT
TGCAGTGGTAGCTGTGGGCCCATCTTTCGAGCCAATATGAACACTGGGGACCCTTCTAAG
CCCAAGAGTGTTATTCTCAAGGCTTTAAAAGAACCAGCTGGGCTCCATGAGGTACAAGAT
TTCTTAGGGCGAATCCAATTCCATCAATACCTGGGGAAACACAAAAACCTGGTGCAGCTG
GAAGGCTGCTGCACTGAAAAGCTGCCACTCTATGTGGTGTTGGAGGATGTGGCCCAGGGG
GACCTGCTCGGCTTTCTCTGGACCTGTCGGCGGGATGTGATGACTATGGATGGTCTTCTC
TATGATCTCACAGAAAAACAAGTATATCACATCGGAAAGCAGGTCCTTTTGGCGCTGGAA
TTCCTGCAGGAGAAGCATTTGTTCCATGGGGATGTGGCAGCCAGGAATATTCTGATGCAA
AGTGATCTCACTGCTAAGCTCTGTGGATTAGGCCTGGCTTATGAAGTTTACACCCGAGGG
GCCATCTCCTCTACTCAAACCATACCTCTCAAGTGGCTTGCCCCAGAACGGCTTCTCCTG
AGACCTGCTCGCATCAGAGCAGATGTCTGGTCTTTTGGGATCCTGCTCTATGAGATGGTG
ACTCTAGGAGCACCACCGTATCCTGAAGTCCCTCCTACCAGCATCCTAGAGCATCTCCAA
AGAAGGAAAATCATGAAGAGACCCAGTAGCTGCACACATACCATGTACAGTATCATGAAG
TCCTGCTGGCGCTGGCGTGAGGCTGACCGCCCCTCACCTAGAGAGCTGCGCTTGCGCCTA
GAAGCTGCCATTAAAACTGCAGATGACGAGGCTGTGTTACAAGTACCAGAGTTGGTGGTA
CCTGAACTGTATGCAGCTGTGGCCGGCATCAGAGTGGAGAGCCTCTTCTACAACTATAGC
ATGCTTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 422 |
| Molecular Weight
| 47546.3 |
| Theoretical pI
| 7.45 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Tyrosine-protein kinase STYK1
MGMTRMLLECSLSDKLCVIQEKQYEVIIVPTLLVTIFLILLGVILWLFIREQRTQQQRSG
PQGIAPVPPPRDLSWEAGHGGNVALPLKETSVENFLGATTPALAKLQVPREQLSEVLEQI
CSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQL
EGCCTEKLPLYMVLEDVAQGDLLGFLWTCRRDVMTMDGLLYDLTEKQVYHIGKQVLLALE
FLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQTIPLKWLAPERLLL
RPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMK
SCWRWREADRPSPRELRLRLEAAIKTADDEAVLQVPELVVPELYAAVAGIRVESLFYNYS
ML
|
| External Links |
|---|
| GenBank ID Protein
| 13625180 |
| UniProtKB/Swiss-Prot ID
| Q6J9G0 |
| UniProtKB/Swiss-Prot Entry Name
| STYK1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF251059 |
| GeneCard ID
| STYK1 |
| GenAtlas ID
| STYK1 |
| HGNC ID
| HGNC:18889 |
| References |
|---|
| General References
| Not Available |