Cannabis Compound Database: Showing Protein Serine/threonine-protein kinase Nek8 (CDBP01385)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP01385

Secondary Accession Numbers

Not Available

Name

Serine/threonine-protein kinase Nek8

Description

Not Available

Synonyms

Never in mitosis A-related kinase 8
NimA-related protein kinase 8
Nima-related protein kinase 12a

Gene Name

NEK8

Protein Type

Enzyme

Biological Properties

General Function

Involved in protein kinase activity

Specific Function

Required for renal tubular integrity

GO Classification

Function
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
protein kinase activity
protein serine/threonine kinase activity
Process
protein amino acid phosphorylation
phosphorylation
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular metabolic process

Cellular Location

Cytoplasm

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

17q11.1

SNPs

NEK8

Gene Sequence

>2079 bp
ATGGAGAAGTACGAGCGGATCCGAGTGGTGGGGAGAGGTGCCTTCGGGATTGTGCACCTG
TGCCTGCGAAAGGCTGACCAGAAGCTGGTGATCATCAAGCAGATTCCAGTGGAACAGATG
ACCAAGGAAGAGCGGCAGGCAGCCCAGAATGAGTGCCAGGTCCTCAAGCTGCTCAACCAC
CCCAATGTCATTGAGTACTACGAGAACTTCCTGGAAGACAAAGCCCTTATGATCGCCATG
GAATATGCACCAGGCGGCACTCTGGCTGAGTTCATCCAAAAGCGCTGTAATTCCCTGCTG
GAGGAGGAGACCATCCTGCACTTCTTCGTGCAGATCCTGCTTGCACTGCATCATGTGCAC
ACCCACCTCATCCTGCACCGAGACCTCAAGACCCAGAACATCCTGCTTGACAAACACCGC
ATGGTCGTCAAGATCGGTGATTTCGGCATCTCCAAGATCCTTAGCAGCAAGAGCAAGGCC
TACACGGTGGTGGGTACCCCATGCTATATCTCCCCTGAGCTGTGTGAGGGCAAGCCCTAC
AACCAGAAGAGTGACATCTGGGCCCTGGGCTGTGTCCTCTACGAGCTGGCCAGCCTCAAG
AGGGCTTTCGAGGCTGCGAACTTGCCAGCACTGGTGCTGAAGATCATGAGTGGCACCTTT
GCACCTATCTCTGACCGGTACAGCCCTGAGCTTCGCCAGCTGGTCCTGAGTCTACTCAGC
CTGGAGCCTGCCCAGCGGCCACCACTCAGCCACATCATGGCACAGCCCCTCTGCATCCGT
GCCCTCCTCAACCTCCACACCGACGTGGGCAGTGTCCGCATGCGGAGGGCAGAGAAGTCC
GTGGCCCCCAGCAACACAGGGAGCAGGACCACCAGTGTCCGCTGCAGAGGTATCCCCCGG
GGACCTGTGAGGCCAGCCATCCCACCACCACTGTCGTCAGTGTATGCCTGGGGTGGTGGG
CTGGGCACCCCCCTGCGGCTGCCAATGCTCAACACAGAGGTGGTCCAGGTGGCAGCTGGG
CGCACGCAGAAAGCCGGCGTCACGCGCTCTGGGCGTCTCATCCTGTGGGAGGCCCCACCC
CTAGGTGCAGGCGGAGGCAGTCTCCTTCCTGGGGCAGTGGAGCAGCCACAGCCCCAGTTC
ATCTCGCGTTTCCTGGAGGGCCAGTCGGGTGTGACCATCAAGCACGTGGCCTGTGGGGAC
TTCTTCACTGCCTGCCTGACTGACAGAGGCATCATCATGACATTCGGCAGCGGCAGCAAT
GGGTGCCTAGGCCATGGCAGCCTCACTGACATCAGCCAGCCCACCATTGTGGAGGCTTTG
CTGGGCTATGAAATGGTGCAGGTGGCCTGTGGGGCCTCTCACGTGCTGGCCCTGTCCACT
GAGCGAGAACTATTTGCCTGGGGCCGTGGAGACAGCGGCAGACTGGGGCTAGGCACCAGG
GAGTCCCACAGCTGCCCCCAGCAGGTGCCCATGCCCCCAGGACAGGAAGCTCAGCGAGTT
GTATGTGGTATCGATTCCTCCATGATCCTCACTGTGCCTGGCCAAGCCCTAGCCTGTGGG
AGCAACAGGTTCAACAAGCTGGGCCTGGACCACCTCTCCCTGGGGGAGGAGCCTGTCCCC
CACCAGCAAGTGGAGGAGGCCCTGAGCTTCACACTACTAGGCTCTGCACCCCTGGACCAG
GAGCCTCTGCTGAGTATAGACCTGGGCACTGCTCACTCAGCTGCTGTGACTGCCTCGGGT
GATTGCTACACTTTTGGCAGCAATCAGCACGGACAGTTGGGCACCAATACTCGCCGAGGC
AGTCGGGCACCCTGTAAGGTCCAAGGCCTTGAGGGCATCAAGATGGCAATGGTAGCCTGT
GGGGATGCCTTCACTGTAGCTATTGGGGCAGAGAGCGAAGTGTACTCTTGGGGCAAAGGG
GCGCGAGGTCGATTGGGAAGGAGGGATGAGGATGCCGGACTCCCTCGGCCAGTGCAGTTG
GATGAGACACACCCTTACACGGTGACTTCCGTGTCCTGTTGCCATGGAAACACCCTCCTG
GCTGTTCGATCGGTCACAGATGAGCCGGTCCCCCCCTGA

Protein Properties

Number of Residues

692

Molecular Weight

74805.6

Theoretical pI

7.85

Pfam Domain Function

Pkinase (PF00069 )
RCC1 (PF00415 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>Serine/threonine-protein kinase Nek8
MEKYERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNH
PNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVH
THLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPY
NQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLS
LEPAQRPPLSHIMAQPLCIRALLNLHTDVGSVRMRRAEKSVAPSNTGSRTTSVRCRGIPR
GPVRPAIPPPLSSVYAWGGGLGTPLRLPMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPP
LGAGGGSLLPGAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSN
GCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTR
ESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVP
HQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRG
SRAPCKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLGRRDEDAGLPRPVQL
DETHPYTVTSVSCCHGNTLLAVRSVTDEPVPP

External Links

GenBank ID Protein

30039692

UniProtKB/Swiss-Prot ID

Q86SG6

UniProtKB/Swiss-Prot Entry Name

NEK8_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_178170.2

GeneCard ID