| Identification |
|---|
| HMDB Protein ID
| CDBP01344 |
| Secondary Accession Numbers
| Not Available |
| Name
| Microtubule-associated serine/threonine-protein kinase 2 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| MAST2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein serine/threonine kinase activity |
| Specific Function
| Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation |
| GO Classification
|
| Function |
| atp binding |
| magnesium ion binding |
| protein binding |
| protein kinase activity |
| ion binding |
| protein serine/threonine kinase activity |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| metabolic process |
| cellular metabolic process |
| protein amino acid phosphorylation |
| phosphorylation |
|
| Cellular Location
|
- Cell membrane
- Cytoplasm
- Peripheral membrane protein
- cytoskeleton
- Cytoplasmic side (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p34.1 |
| SNPs
| MAST2 |
| Gene Sequence
|
>5397 bp
ATGAAGCGGAGCCGCTGCCGCGACCGACCGCAGCCGCCGCCGCCCGACCGCCGGGAGGAT
GGAGTTCAGCGGGCAGCGGAGCTGTCTCAGTCTTTGCCGCCGCGCCGGCGAGCGCCGCCC
GGGAGGCAGCGGCTGGAGGAGCGGACGGGCCCCGCGGGGCCCGAGGGCAAGGAGCAGGAT
GTAGTAACTGGAGTTAGTCCCCTGCTCTTCAGGAAACTCAGTAATCCTGACATATTTTCA
TCCACTGGAAAAGTTAAACTTCAGCGACAACTGAGTCAGGATGATTGTAAGTTATGGAGA
GGAAACCTGGCCAGCTCTCTATCGGGTAAGCAGCTGCTCCCTTTGTCCAGCAGTGTACAT
AGCAGTGTGGGACAGGTGACTTGGCAGTCGTCAGGAGAAGCATCAAACCTGGTTCGAATG
AGAAACCAGTCCCTTGGACAGTCTGCACCTTCTCTTACTGCTGGCCTGAAGGAGTTGAGC
CTTCCAAGAAGAGGCAGCTTTTGTCGGACAAGTAACCGCAAGAGCTTGATTGTGACCTCT
AGCACATCACCTACACTACCACGGCCACACTCACCACTCCATGGCCACACAGGTAACAGT
CCTTTGGACAGCCCCCGGAATTTCTCTCCAAATGCACCTGCTCACTTTTCTTTTGTTCCT
GCCCGTAGGACTGATGGGCGGCGCTGGTCTTTGGCCTCTTTGCCCTCTTCAGGATATGGA
ACTAACACTCCTAGCTCCACTGTCTCATCATCATGCTCCTCACAGGAAAAGCTGCATCAG
TTGCCTTTCCAGCCTACAGCTGATGAGCTGCACTTTTTGACGAAGCATTTCAGCACAGAG
AGCGTACCAGATGAGGAAGGACGGCAGTCCCCAGCCATGCGGCCTCGCTCCCGGAGCCTC
AGTCCCGGACGATCCCCAGTATCCTTTGACAGTGAAATAATAATGATGAATCATGTTTAC
AAAGAAAGATTCCCAAAGGCCACCGCACAAATGGAAGAGCGACTAGCAGAGTTTATTTCC
TCCAACACTCCAGACAGCGTGCTGCCCTTGGCAGATGGAGCCCTGAGCTTTATTCATCAT
CAGGTGATTGAGATGGCCCGAGACTGCCTGGATAAATCTCGGAGTGGCCTCATTACATCA
CAATACTTCTACGAACTTCAAGATAATTTGGAGAAACTTTTACAAGATGCTCATGAGCGC
TCAGAGAGCTCAGAAGTGGCTTTTGTGATGCAGCTGGTGAAAAAGCTGATGATTATCATT
GCCCGCCCAGCACGTCTCCTGGAATGCCTGGAGTTTGACCCTGAAGAGTTCTACCACCTT
TTAGAAGCAGCTGAGGGCCACGCCAAAGAGGGACAAGGGATTAAATGTGACATTCCCCGC
TACATCGTTAGCCAGCTGGGCCTCACCCGGGATCCCCTAGAAGAAATGGCCCAGTTGAGC
AGCTGTGACAGTCCTGACACTCCAGAGACAGATGATTCTATTGAGGGCCATGGGGCATCT
CTGCCATCTAAAAAGACACCCTCTGAAGAGGACTTCGAGACCATTAAGCTCATCAGCAAT
GGCGCCTATGGGGCTGTATTTCTGGTGCGGCACAAGTCCACCCGGCAGCGCTTTGCCATG
AAGAAGATCAACAAGCAGAACCTGATCCTACGGAACCAGATCCAGCAGGCCTTCGTGGAG
CGTGACATACTGACTTTCGCTGAGAACCCCTTTGTGGTCAGCATGTTCTGCTCCTTTGAT
ACCAAGCGCCACTTGTGCATGGTGATGGAGTACGTTGAAGGGGGAGACTGTGCCACTCTG
CTGAAGAATATTGGGGCCCTGCCTGTGGACATGGTGCGTCTATACTTTGCGGAAACTGTG
CTGGCCCTGGAGTACTTACACAACTATGGCATCGTGCACCGTGACCTCAAGCCTGACAAC
CTCCTAATTACATCCATGGGGCACATCAAGCTCACGGACTTTGGACTGTCCAAAATTGGC
CTCATGAGTCTGACAACGAACTTGTATGAGGGTCATATTGAAAAGGATGCCCGGGAATTC
CTGGACAAGCAGGTATGCGGGACCCCAGAATACATTGCGCCTGAGGTGATCCTGCGCCAG
GGCTATGGGAAGCCAGTGGACTGGTGGGCCATGGGCATTATCCTGTATGAGTTCCTGGTG
GGCTGCGTCCCTTTTTTTGGAGATACTCCGGAGGAGCTCTTTGGGCAGGTGATCAGTGAT
GAGATTGTGTGGCCTGAGGGTGATGAGGCACTGCCCCCAGACGCCCAGGACCTCACCTCC
AAACTGCTCCACCAGAACCCTCTGGAGAGACTTGGCACAGGCAGTGCCTATGAGGTGAAG
CAGCACCCATTCTTTACTGGTCTGGACTGGACAGGACTTCTCCGCCAGAAGGCTGAATTT
ATTCCTCAGTTGGAGTCAGAGGATGATACTAGCTATTTTGACACCCGCTCAGAGCGATAC
CACCACATGGACTCGGAGGATGAGGAAGAAGTGAGTGAGGATGGCTGCCTTGAGATCCGC
CAGTTCTCTTCCTGCTCTCCAAGGTTCAACAAGGTGTACAGCAGCATGGAGCGGCTCTCA
CTGCTCGAGGAGCGCCGGACACCACCCCCGACCAAGCGCAGCCTGAGTGAGGAGAAGGAG
GACCATTCAGATGGCCTGGCAGGGCTCAAAGGCCGAGACCGGAGCTGGGTGATTGGCTCC
CCTGAGATATTACGGAAGCGGCTGTCGGTGTCTGAGTCATCCCACACAGAGAGTGACTCA
AGCCCTCCAATGACAGTGCGACGCCGCTGCTCAGGCCTCCTGGATGCGCCTCGGTTCCCG
GAGGGCCCTGAGGAGGCCAGCAGCACCCTCAGGAGGCAACCACAGGAGGGTATATGGGTC
CTGACACCCCCATCTGGAGAGGGGGTATCTGGGCCTGTCACTGAACACTCAGGGGAGCAG
CGGCCAAAGCTGGATGAGGAAGCTGTTGGCCGGAGCAGTGGTTCCAGTCCAGCTATGGAG
ACCCGAGGCCGTGGGACCTCACAGCTGGCTGAGGGAGCCACAGCCAAGGCCATCAGTGAC
CTGGCTGTGCGTAGGGCCCGCCACCGGCTGCTCTCTGGGGACTCAACAGAGAAGCGCACT
GCTCGCCCTGTCAACAAAGTGATCAAGTCCGCCTCAGCCACAGCCCTCTCACTCCTCATT
CCTTCGGAACACCACACCTGCTCCCCGTTGGCCAGCCCCATGTCCCCACATTCTCAGTCG
TCCAACCCATCATCCCGGGACTCTTCTCCAAGCAGGGACTTCTTGCCAGCCCTTGGCAGC
ATGAGGCCTCCCATCATCATCCACCGAGCTGGCAAGAAGTATGGCTTCACCCTGCGGGCC
ATTCGCGTCTACATGGGTGACTCCGATGTCTACACCGTGCACCATATGGTGTGGCACGTG
GAGGATGGAGGTCCGGCCAGTGAGGCAGGGCTTCGTCAAGGTGACCTCATCACCCATGTC
AATGGGGAACCTGTGCATGGCCTGGTGCACACGGAGGTGGTAGAGCTGATCCTGAAGAGT
GGAAACAAGGTGGCCATTTCAACAACTCCCCTGGAGAACACATCCATTAAAGTGGGGCCA
GCTCGGAAGGGCAGCTACAAGGCCAAGATGGCCCGAAGGAGCAAGAGGAGCCGCGGCAAG
GATGGGCAAGAAAGCAGAAAAAGGAGCTCCCTGTTCCGCAAGATCACCAAGCAAGCATCC
CTGCTCCACACCAGCCGCAGCCTTTCTTCCCTTAACCGCTCCTTGTCATCAGGGGAGAGT
GGGCCAGGCTCTCCCACACACAGCCACAGCCTTTCCCCCCGATCTCCCACTCAAGGCTAC
CGGGTGACCCCCGATGCTGTGCATTCAGTGGGAGGGAATTCATCACAGAGCAGCTCCCCC
AGCTCCAGCGTGCCCAGTTCCCCAGCCGGCTCTGGGCACACACGGCCCAGCTCCCTCCAC
GGTCTGGCACCCAAGCTCCAACGCCAGTACCGCTCTCCACGGCGCAAGTCAGCAGGCAGC
ATCCCACTGTCACCACTGGCCCACACCCCTTCTCCCCCACCCCCAACAGCTTCACCTCAG
CGGTCCCCATCGCCCCTGTCTGGCCATGTAGCCCAGGCCTTTCCCACAAAGCTTCACTTG
TCACCTCCCCTGGGCAGGCAACTCTCACGGCCCAAGAGTGCGGAGCCACCCCGTTCACCA
CTACTCAAGAGGGTGCAGTCGGCTGAGAAACTGGCAGCAGCACTTGCCGCCTCTGAGAAG
AAGCTAGCCACTTCTCGCAAGCACAGCCTTGACCTGCCCCACTCTGAACTAAAGAAGGAA
CTGCCGCCCAGGGAAGTGAGCCCTCTGGAGGTAGTTGGAGCCAGGAGTGTGCTGTCTGGC
AAGGGGGCCCTGCCAGGGAAGGGGGTGCTGCAGCCTGCTCCCTCACGGGCCCTAGGCACC
CTCCGGCAGGACCGAGCCGAACGACGGGAGTCGCTGCAGAAGCAAGAAGCCATTCGTGAG
GTGGACTCCTCAGAGGACGACACCGAGGAAGGGCCTGAGAACAGCCAGGGTGCACAGGAG
CTGAGCTTGGCACCTCACCCAGAAGTGAGCCAGAGTGTGGCCCCTAAAGGAGCAGGAGAG
AGTGGGGAAGAGGATCCTTTCCCGTCCAGAGACCCTAGGAGCCTGGGCCCAATGGTCCCA
AGCCTATTGACAGGGATCACACTGGGGCCTCCCAGAATGGAAAGTCCCAGTGGTCCCCAC
AGGAGGCTCGGGAGCCCACAAGCCATTGAGGAGGCTGCCAGCTCCTCCTCAGCAGGCCCC
AACCTAGGTCAGTCTGGAGCCACAGACCCCATCCCTCCTGAAGGTTGCTGGAAGGCCCAG
CACCTCCACACCCAGGCACTAACAGCACTTTCTCCCAGCACTTCGGGACTCACCCCCACC
AGCAGTTGCTCTCCTCCCAGCTCCACCTCTGGGAAGCTGAGCATGTGGTCCTGGAAATCC
CTTATTGAGGGCCCAGACAGGGCATCCCCAAGCAGAAAGGCAACCATGGCAGGTGGGCTA
GCCAACCTCCAGGATTTGGAAAACACAACTCCAGCCCAGCCTAAGAACCTGTCTCCCAGG
GAGCAGGGGAAGACACAGCCACCTAGTGCCCCCAGACTGGCCCATCCATCTTATGAGGAT
CCCAGCCAGGGCTGGCTATGGGAGTCTGAGTGTGCACAAGCAGTGAAAGAGGATCCAGCC
CTGAGCATCACCCAAGTGCCTGATGCCTCAGGTGACAGAAGGCAGGACGTTCCATGCCGA
GGCTGCCCCCTCACCCAGAAGTCTGAGCCCAGCCTCAGGAGGGGCCAAGAACCAGGGGGC
CATCAAAAGCATCGGGATTTGGCATTGGTTCCAGATGAGCTTTTAAAGCAAACATAG
|
| Protein Properties |
|---|
| Number of Residues
| 1798 |
| Molecular Weight
| 196433.8 |
| Theoretical pI
| 8.26 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Microtubule-associated serine/threonine-protein kinase 2
MKRSRCRDRPQPPPPDRREDGVQRAAELSQSLPPRRRAPPGRQRLEERTGPAGPEGKEQD
VVTGVSPLLFRKLSNPDIFSSTGKVKLQRQLSQDDCKLWRGNLASSLSGKQLLPLSSSVH
SSVGQVTWQSSGEASNLVRMRNQSLGQSAPSLTAGLKELSLPRRGSFCRTSNRKSLIVTS
STSPTLPRPHSPLHGHTGNSPLDSPRNFSPNAPAHFSFVPARRTDGRRWSLASLPSSGYG
TNTPSSTVSSSCSSQEKLHQLPFQPTADELHFLTKHFSTESVPDEEGRQSPAMRPRSRSL
SPGRSPVSFDSEIIMMNHVYKERFPKATAQMEERLAEFISSNTPDSVLPLADGALSFIHH
QVIEMARDCLDKSRSGLITSQYFYELQDNLEKLLQDAHERSESSEVAFVMQLVKKLMIII
ARPARLLECLEFDPEEFYHLLEAAEGHAKEGQGIKCDIPRYIVSQLGLTRDPLEEMAQLS
SCDSPDTPETDDSIEGHGASLPSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAM
KKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATL
LKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIG
LMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLV
GCVPFFGDTPEELFGQVISDEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVK
QHPFFTGLDWTGLLRQKAEFIPQLESEDDTSYFDTRSERYHHMDSEDEEEVSEDGCLEIR
QFSSCSPRFNKVYSSMERLSLLEERRTPPPTKRSLSEEKEDHSDGLAGLKGRDRSWVIGS
PEILRKRLSVSESSHTESDSSPPMTVRRRCSGLLDAPRFPEGPEEASSTLRRQPQEGIWV
LTPPSGEGVSGPVTEHSGEQRPKLDEEAVGRSSGSSPAMETRGRGTSQLAEGATAKAISD
LAVRRARHRLLSGDSTEKRTARPVNKVIKSASATALSLLIPSEHHTCSPLASPMSPHSQS
SNPSSRDSSPSRDFLPALGSMRPPIIIHRAGKKYGFTLRAIRVYMGDSDVYTVHHMVWHV
EDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVAISTTPLENTSIKVGP
ARKGSYKAKMARRSKRSRGKDGQESRKRSSLFRKITKQASLLHTSRSLSSLNRSLSSGES
GPGSPTHSHSLSPRSPTQGYRVTPDAVHSVGGNSSQSSSPSSSVPSSPAGSGHTRPSSLH
GLAPKLQRQYRSPRRKSAGSIPLSPLAHTPSPPPPTASPQRSPSPLSGHVAQAFPTKLHL
SPPLGRQLSRPKSAEPPRSPLLKRVQSAEKLAAALAASEKKLATSRKHSLDLPHSELKKE
LPPREVSPLEVVGARSVLSGKGALPGKGVLQPAPSRALGTLRQDRAERRESLQKQEAIRE
VDSSEDDTEEGPENSQGAQELSLAPHPEVSQSVAPKGAGESGEEDPFPSRDPRSLGPMVP
SLLTGITLGPPRMESPSGPHRRLGSPQAIEEAASSSSAGPNLGQSGATDPIPPEGCWKAQ
HLHTQALTALSPSTSGLTPTSSCSPPSSTSGKLSMWSWKSLIEGPDRASPSRKATMAGGL
ANLQDLENTTPAQPKNLSPREQGKTQPPSAPRLAHPSYEDPSQGWLWESECAQAVKEDPA
LSITQVPDASGDRRQDVPCRGCPLTQKSEPSLRRGQEPGGHQKHRDLALVPDELLKQT
|
| External Links |
|---|
| GenBank ID Protein
| 112363080 |
| UniProtKB/Swiss-Prot ID
| Q6P0Q8 |
| UniProtKB/Swiss-Prot Entry Name
| MAST2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_015112.2 |
| GeneCard ID
| MAST2 |
| GenAtlas ID
| MAST2 |
| HGNC ID
| HGNC:19035 |
| References |
|---|
| General References
| Not Available |