Showing Protein Ceramide kinase (CDBP01308)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 4 compounds
Identification
HMDB Protein ID CDBP01308
Secondary Accession Numbers Not Available
Name Ceramide kinase
Description Not Available
Synonyms
  1. Acylsphingosine kinase
  2. LK4
  3. Lipid kinase 4
  4. hCERK
Gene Name CERK
Protein Type Enzyme
Biological Properties
General Function Involved in diacylglycerol kinase activity
Specific Function Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides
GO Classification
Function
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
diacylglycerol kinase activity
Process
activation of protein kinase c activity by g-protein coupled receptor protein signaling pathway
signaling
signaling pathway
cell surface receptor linked signaling pathway
g-protein coupled receptor protein signaling pathway
Cellular Location
  1. Cytoplasm
  2. Peripheral membrane protein
  3. Membrane
Pathways
Gene Properties
Chromosome Location Chromosome:2
Locus 22q13.31
SNPs CERK
Gene Sequence 
>1614 bp
ATGGGGGCGACGGGGGCGGCGGAGCCGCTGCAATCCGTGCTGTGGGTGAAGCAGCAGCGC
TGCGCCGTGAGCCTGGAGCCCGCGCGGGCTCTGCTGCGCTGGTGGCGGAGCCCGGGGCCC
GGAGCCGGCGCCCCCGGCGCGGATGCCTGCTCTGTGCCTGTATCTGAGATCATCGCCGTT
GAGGAAACAGACGTTCACGGGAAACATCAAGGCAGTGGAAAATGGCAGAAAATGGAAAAG
CCTTACGCTTTTACAGTTCACTGTGTAAAGAGAGCACGACGGCACCGCTGGAAGTGGGCG
CAGGTGACTTTCTGGTGTCCAGAGGAGCAGCTGTGTCACTTGTGGCTGCAGACCCTGCGG
GAGATGCTGGAGAAGCTGACGTCCAGACCAAAGCATTTACTGGTATTTATCAACCCGTTT
GGAGGAAAAGGACAAGGCAAGCGGATATATGAAAGAAAAGTGGCACCACTGTTCACCTTA
GCCTCCATCACCACTGACATCATCGTTACTGAACATGCTAATCAGGCCAAGGAGACTCTG
TATGAGATTAACATAGACAAATACGACGGCATCGTCTGTGTCGGCGGAGATGGTATGTTC
AGCGAGGTGCTGCACGGTCTGATTGGGAGGACGCAGAGGAGCGCCGGGGTCGACCAGAAC
CACCCCCGGGCTGTGCTGGTCCCCAGTAGCCTCCGGATTGGAATCATTCCCGCAGGGTCA
ACGGACTGCGTGTGTTACTCCACCGTGGGCACCAGCGACGCAGAAACCTCGGCGCTGCAT
ATCGTTGTTGGGGACTCGCTGGCCATGGATGTGTCCTCAGTCCACCACAACAGCACACTC
CTTCGCTACTCCGTGTCCCTGCTGGGCTACGGCTTCTACGGGGACATCATCAAGGACAGT
GAGAAGAAACGGTGGTTGGGTCTTGCCAGATACGACTTTTCAGGTTTAAAGACCTTCCTC
TCCCACCACTGCTATGAAGGGACAGTGTCCTTCCTCCCTGCACAACACACGGTGGGATCT
CCAAGGGATAGGAAGCCCTGCCGGGCAGGATGCTTTGTTTGCAGGCAAAGCAAGCAGCAG
CTGGAGGAGGAGCAGAAGAAAGCACTGTATGGTTTGGAAGCTGCGGAGGACGTGGAGGAG
TGGCAAGTCGTCTGTGGGAAGTTTCTGGCCATCAATGCCACAAACATGTCCTGTGCTTGT
CGCCGGAGCCCCAGGGGCCTCTCCCCGGCTGCCCACTTGGGAGACGGGTCTTCTGACCTC
ATCCTCATCCGGAAATGCTCCAGGTTCAATTTTCTGAGATTTCTCATCAGGCACACCAAC
CAGCAGGACCAGTTTGACTTCACTTTTGTTGAAGTTTATCGCGTCAAGAAATTCCAGTTT
ACGTCGAAGCACATGGAGGATGAGGACAGCGACCTCAAGGAGGGGGGGAAGAAGCGCTTT
GGGCACATTTGCAGCAGCCACCCCTCCTGCTGCTGCACCGTCTCCAACAGCTCCTGGAAC
TGCGATGGGGAGGTCCTGCACAGCCCTGCCATCGAGGTCAGAGTCCACTGCCAGCTGGTT
CGACTCTTTGCACGAGGAATTGAAGAGAATCCGAAGCCAGACTCACACAGCTGA
Protein Properties
Number of Residues 537
Molecular Weight 59977.0
Theoretical pI 8.24
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Ceramide kinase
MGATGAAEPLQSVLWVKQQRCAVSLEPARALLRWWRSPGPGAGAPGADACSVPVSEIIAV
EETDVHGKHQGSGKWQKMEKPYAFTVHCVKRARRHRWKWAQVTFWCPEEQLCHLWLQTLR
EMLEKLTSRPKHLLVFINPFGGKGQGKRIYERKVAPLFTLASITTDIIVTEHANQAKETL
YEINIDKYDGIVCVGGDGMFSEVLHGLIGRTQRSAGVDQNHPRAVLVPSSLRIGIIPAGS
TDCVCYSTVGTSDAETSALHIVVGDSLAMDVSSVHHNSTLLRYSVSLLGYGFYGDIIKDS
EKKRWLGLARYDFSGLKTFLSHHCYEGTVSFLPAQHTVGSPRDRKPCRAGCFVCRQSKQQ
LEEEQKKALYGLEAAEDVEEWQVVCGKFLAINATNMSCACRRSPRGLSPAAHLGDGSSDL
ILIRKCSRFNFLRFLIRHTNQQDQFDFTFVEVYRVKKFQFTSKHMEDEDSDLKEGGKKRF
GHICSSHPSCCCTVSNSSWNCDGEVLHSPAIEVRVHCQLVRLFARGIEENPKPDSHS
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q8TCT0
UniProtKB/Swiss-Prot Entry Name CERK1_HUMAN
PDB IDs Not Available
GenBank Gene ID AB079066
GeneCard ID CERK
GenAtlas ID CERK
HGNC ID HGNC:19256
References
General References Not Available