Showing Protein ATP synthase subunit O, mitochondrial (CDBP01195)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 3 compounds
Identification
HMDB Protein ID CDBP01195
Secondary Accession Numbers Not Available
Name ATP synthase subunit O, mitochondrial
Description Not Available
Synonyms
  1. OSCP
  2. Oligomycin sensitivity conferral protein
Gene Name ATP5O
Protein Type Enzyme
Biological Properties
General Function Involved in hydrogen ion transporting ATP synthase activity, rotational mechanism
Specific Function Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements
GO Classification
Component
cell part
proton-transporting atp synthase complex, catalytic core f(1)
proton-transporting two-sector atpase complex, catalytic domain
plasma membrane
macromolecular complex
protein complex
membrane
Function
hydrogen ion transporting atp synthase activity, rotational mechanism
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
cation transmembrane transporter activity
inorganic cation transmembrane transporter activity
monovalent inorganic cation transmembrane transporter activity
hydrogen ion transmembrane transporter activity
transporter activity
Process
purine nucleotide biosynthetic process
purine nucleoside triphosphate biosynthetic process
purine ribonucleoside triphosphate biosynthetic process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
atp synthesis coupled proton transport
atp biosynthetic process
purine nucleotide metabolic process
Cellular Location
  1. Mitochondrion
  2. Mitochondrion inner membrane
Pathways
Gene Properties
Chromosome Location Chromosome:2
Locus 21q22.1-q22.2|21q22.11
SNPs ATP5O
Gene Sequence 
>642 bp
ATGGCTGCCCCAGCAGTGTCCGGGCTCTCCCGGCAGGTGCGATGCTTCAGTACCTCTGTG
GTCAGACCATTTGCCAAGCTTGTGAGGCCTCCTGTTCAGGTATACGGTATTGAAGGTCGC
TATGCCACAGCTCTTTATTCTGCTGCATCAAAACAGAATAAGCTGGAGCAAGTAGAAAAG
GAGTTGTTGAGAGTAGCACAAATCCTGAAGGAACCCAAAGTGGCTGCTTCTGTTTTGAAT
CCCTATGTGAAGCGTTCCATTAAAGTGAAAAGCCTAAATGACATCACAGCAAAAGAGAGG
TTCTCTCCCCTCACTACCAACCTGATCAATTTGCTTGCTGAAAATGGTCGATTAAGCAAT
ACCCAAGGAGTCGTTTCTGCCTTTTCTACCATGATGAGTGTCCATCGCGGAGAGGTACCT
TGCACAGTGACCTCTGCATCTCCTTTAGAAGAAGCCACACTCTCTGAATTAAAAACTGTC
CTCAAGAGCTTCCTAAGTCAAGGCCAAGTATTGAAATTGGAGGCTAAGACTGATCCGTCA
ATCTTGGGTGGAATGATTGTGCGCATTGGCGAGAAATATGTTGACATGTCTGTCAAGACC
AAGATTCAGAAGCTGGGCAGGGCTATGCGGGAGATTGTCTAA
Protein Properties
Number of Residues 213
Molecular Weight 23277.1
Theoretical pI 10.61
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>ATP synthase subunit O, mitochondrial
MAAPAVSGLSRQVRCFSTSVVRPFAKLVRPPVQVYGIEGRYATALYSAASKQNKLEQVEK
ELLRVAQILKEPKVAASVLNPYVKRSIKVKSLNDITAKERFSPLTTNLINLLAENGRLSN
TQGVVSAFSTMMSVHRGEVPCTVTSASPLEEATLSELKTVLKSFLSQGQVLKLEAKTDPS
ILGGMIVRIGEKYVDMSVKTKIQKLGRAMREIV
GenBank ID Protein 1008080
UniProtKB/Swiss-Prot ID P48047
UniProtKB/Swiss-Prot Entry Name ATPO_HUMAN
PDB IDs Not Available
GenBank Gene ID X83218
GeneCard ID ATP5O
GenAtlas ID ATP5O
HGNC ID HGNC:850
References
General References Not Available